Microstructural finite strain analysis of the Hafafit granitoids domes South Central Eastern desert of Egypt

The Wadi Hafafit Culmination (WHC) can be subdivided into two main units which are separated by Nugrus thrust shear zone. The WHC domes are occupies the southern part of the Central Eastern Desert of Egypt and is cored by five separated gneissic granitoids ranging in composition from tonalite to granodiorite having compositions consistent with hydrous partial melting of a mafic source suggesting subduction-related magmatism. The leucogranites along thrust zones is related to the late phase of metamorphism of Hafafit rocks. The five main domes of the WHC have been labeled A dome occupies the northern part of WHC, B and C domes occupies the central eastern part of WHC, D dome occupies the central western part of WHC and E dome occupies the southern part of WHC. The fourth domes A, B, C and E are affected by more than one deformation event but D dome is affected by one deformation event. The domes not uniform throughout the WHC according radial pattern of stretching lineation but these domes of WHC were subjected and affected by late-orogenic extension that was controlled by the Najd transform faults and that resulted in exhumation of the WHC domes are oriented NW-SE parallel to the trend of the left-lateral shear zones of Najd fault system

Adaptive Coping During Protracted Political Conflict, War and Military Blockade in Gaza

Identifying culturally-relevant concepts and coping mechanisms can help protect civilian wellbeing. This study explores how seven professional Palestinian university graduates in the Gaza Strip (occupied Palestinian territories) cope with war, military occupation, military blockade and the challenges of living in a conflict-affected area. Participants were interviewed to determine whether culturally specific modes of coping were used. Thematic analysis was applied. The use of resistance and more specifically, sumud , being steadfast and persevering, were identified alongside the motivation to persevere and other adaptive responses to living conditions. Coping strategies identified in this study include adapting, problem-solving, accepting reality, exercising patience, utilising social support, and faith in God (iman) and religion. The implications of this study and the relevance of the findings to mental health and disaster relief are considered

Social suffering and the psychological impact of structural violence and economic oppression in an ongoing conflict setting: The Gaza Strip

Structural violence and economic oppression (e.g. control over resources, politically engineered poverty and unemployment) are common features of warfare, yet there is a lack of research exploring the impact this has on civilian wellbeing in conflict‐affected areas. This study, embedded within a human rights and community liberation psychology framework, aims to address this need by studying young Palestinian university graduates living under military blockade and occupation in the Gaza Strip. Semi‐structured interviews were conducted. Thematic analysis indicated that economic and political domains adversely affected multiple aspects of civilian life and wellbeing. The findings revealed the deleterious effects of structural violence and economic oppression which created: human insecurity; poor psychological wellbeing and quality of life; existential, psychological and social suffering; humiliation; injuries to dignity; multiple losses; and led to life being experienced as ‘on hold’. Local expressions and idioms to express distress were identified. The findings contributed to unique insights regarding how continual, systemic, and structural oppression can be potentially more psychologically detrimental than specific incidents of conflict and violence. The implications and the relevance of the findings to mental health and disaster relief are considered. Interventions providing human security and economic security should be prioritised

The Impact of Restrictive Versus Conservative Intraoperative Fluid Strategies upon the Renal Outcome in Colorectal Surgeries. A Randomized Controlled Trial

Background: intraoperative fluid handling has a lot of concerns upon the postoperative organ function. One of the most sensitive organs which could be affected is the kidney. Objectives: We conducted this trial to address the impact of restrictive vs. conservative fluid approaches on postoperative renal complications, hemodynamics and hospital stay. Patients and methods: Prospective, randomized, double-blind placebo-controlled trial at Assiut University Hospitals. The study included 60 adult patients with American Society of Anesthesiologists (ASA) grade II-III undergoing elective colorectal surgery with an expected operative duration of at least two hours. Grouping was based upon the intraoperative fluid management Group (R): 6 mL/kg/h. of lactated ringer (LR), Group (C): 12 mL/kg/h. of LR. The preoperative serum Neutrophil gelatinase-associated lipocalin (NGAL) level (basal value) then by the 2nd and 24th postoperative hours, KDIGO (Kidney Disease: Improving Global Outcomes), serum urea and creatinine were documented by the end of 1st and 2nd postoperative days. Intraoperative hypovolemia events were noted as well. Results: serum NGAL has increased >149 ng/mlin three patients within group C, and two patients within group R; however, the difference was statistically insignificant p= 0.5. KDIGO showed significant difference between the two groups, with higher number of patients in the group R with p= 0.043. Serum urea and creatinine, intraoperative hypovolemic episodes showed insignificant differences between groups. Conclusion: no evident difference between restrictive and conservative intraoperative fluid strategies was noticed upon the early postoperative serum NGAL and other systems complications in patients undergoing major colorectal surgeries

Time-Fractional Optimal Control of Initial Value Problems on Time Scales

We investigate Optimal Control Problems (OCP) for fractional systems involving fractional-time derivatives on time scales. The fractional-time derivatives and integrals are considered, on time scales, in the Riemann--Liouville sense. By using the Banach fixed point theorem, sufficient conditions for existence and uniqueness of solution to initial value problems described by fractional order differential equations on time scales are known. Here we consider a fractional OCP with a performance index given as a delta-integral function of both state and control variables, with time evolving on an arbitrarily given time scale. Interpreting the Euler--Lagrange first order optimality condition with an adjoint problem, defined by means of right Riemann--Liouville fractional delta derivatives, we obtain an optimality system for the considered fractional OCP. For that, we first prove new fractional integration by parts formulas on time scales.Comment: This is a preprint of a paper accepted for publication as a book chapter with Springer International Publishing AG. Submitted 23/Jan/2019; revised 27-March-2019; accepted 12-April-2019. arXiv admin note: substantial text overlap with arXiv:1508.0075

Physico-mechanical properties and shielding efficiency in relation to mineralogical and geochemical compositions of Um Had granitoid, Central Eastern Desert, Egypt

The current work aims to describe the physico-mechanical characteristics and shielding efficiency with reference to the mineralogical and geochemical compositions of the Neoproterozoic Um Had composite granitoid pluton in order to deduce their favorability as dimension stones. The Um Had granitoid pluton has an elliptical outline with a mean diameter of about 10 km. This pluton is a composite (ranging from white to reddish pink color), hard, massive, and medium- to coarse-grained granitoid body. It is classified as syenogranite according to their modal and bulk chemical compositions. Geochemically, the granitoid pluton is a highly calc-alkaline, peraluminous granite, formed by low degree partial melting of tonalitic source rock in a post-collisional tectonic setting. The physico-mechanical properties of the granitoid pluton under study satisfy the requirements of dimension stone in terms of their bulk density (from 2561 to 2564 kg/m3), and to some extent water absorption capacity (from 0.38% to 0.55%). However, their compressive strength values (50.4–113.4 MPa) do not achieve the minimum requirement for interior use and light duty exterior use. This study delves into the potential of some of our syenogranite samples (I, IIA, IIS, and 10) as gamma radiation shielding materials. We have assessed the mass attenuation coefficient (GMAC), effective atomic number (Zeff), exposure build-up factor (EBF), and energy absorption build-up factor (EABF) for each of these samples. The GMAC and Zeff calculations were performed using the Phy-X online software, across a photon energy range of 0.015–15 MeV. Our findings suggest an inverse relationship between photon energy and GMAC, with the highest values observed for the (I) granite sample (∼18). This study shows the promising radiation shielding capacity of our samples. The insights derived from GMAC, Zeff, EBF, and EABF can serve as a guide for the development of effective, naturally sourced radiation shielding materials. Copyright © 2023 Rashwan, Lasheen, Abdelwahab, Azer, Zakaly, Alarifi, Ene and Thabet.King Saud University, KSUThis research was supported by the Researchers Supporting Project number (RSP2023R496), King Saud University, Riyadh, Saudi Arabia

Relevance of circulating nucleosomes and oncological biomarkers for predicting response to transarterial chemoembolization therapy in liver cancer patients

<p>Abstract</p> <p>Background</p> <p>Transarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers predicting therapy response are urgently required.</p> <p>Methods</p> <p>Here, sera of 50 prospectively and consecutively included HCC patients undergoing 71 TACE therapies were taken before and 3 h, 6 h and 24 h after TACE application to analyze concentrations of circulating nucleosomes, cytokeratin-19 fragments (CYFRA 21-1), alpha fetoprotein (AFP), C-reactive protein (CRP) and several liver biomarkers, and to compare these with radiological response to therapy.</p> <p>Results</p> <p>While nucleosomes, CYFRA 21-1, CRP and some liver biomarkers increased already 24 h after TACE, percental changes of nucleosome concentrations before and 24 h after TACE and pre- and posttherapeutic values of AFP, gamma-glutamyl-transferase (GGT) and alkaline phosphatase (AP) significantly indicated the later therapy response (39 progression versus 32 no progression). In multivariate analysis, nucleosomes (24 h), AP (24 h) and TACE number were independent predictive markers. The risk score of this combination model achieved an AUC of 81.8% in receiver operating characteristic (ROC) curves and a sensitivity for prediction of non-response to therapy of 41% at 97% specificity, and of 72% at 78% specificity.</p> <p>Conclusion</p> <p>Circulating nucleosomes and liver markers are valuable tools for early estimation of the efficacy of TACE therapy in HCC patients.</p