12 research outputs found
NeurogĂ©n gyulladĂĄs, valamint szenzoros neuropeptid felszabadulĂĄs vizsgĂĄlata a capsaicin-Ă©rzĂ©keny idegvĂ©gzĆdĂ©sekbĆl fiziolĂłgiĂĄs Ă©s kĂłros ĂĄllapotokban
Tolperisone-Type Drugs Inhibit Spinal Reflexes via Blockade of Voltage-Gated Sodium and Calcium Channels
VnĂmĂĄnĂ klimatu ĆĄkoly pedagogy 1. stupnÄ ZĆ
Tato zĂĄvÄreÄnĂĄ prĂĄce se zabĂœvĂĄ vnĂmĂĄnĂm ĆĄkolnĂho klimatu na prvnĂm stupni zĂĄkladnĂ ĆĄkoly z pohledu pedagogĆŻ. PrĂĄce mĂĄ teoretickou a praktickou ÄĂĄst. TeoretickĂĄ ÄĂĄst se zabĂœvĂĄ poznatky souvisejĂcĂmi s klimatem. Jsou zde zmĂnÄny pojmy klima ĆĄkoly, klima tĆĂdy, prostĆedĂ a atmosfĂ©ra. TakĂ© jsou uvĂĄdÄny faktory, kterĂ© bezprostĆednÄ klima ĆĄkoly ovlivĆujĂ. CĂlem vĂœzkumnĂ©ho ĆĄetĆenĂ je zjistit, jak vnĂmajĂ klima ĆĄkoly, a to jak reĂĄlnĂ©, tak ideĂĄlnĂ pedagogovĂ© 1. stupnÄ ZĆ venkovskĂ©ho typu. VĂœzkumnĂ© ĆĄetĆenĂ bude provedeno kvalitativnÄ s vyuĆŸitĂm metody dotazovĂĄnĂ
Decreased sensory neuropeptide release from trachea of rats with streptozotocin-induced diabetes
RGH-397 INHIBITS THE FUNCTION OF ALPHA5 GABAA RECEPTORS WITH SLOW OFF-KINETICS AND SHOWS EFFICACY IN ANIMAL MODELS OF COGNITIVE IMPAIRMENT
Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia
Inhibitory Effect of Somatostatin Receptor Subtype-4 Agonist NNC 26-9100 on Micturition Reflex in Rats
Anti-inflammatory effect of synthetic somatostatin analogues in the rat
1. Somatostatin (6.11ânmolâkg(â1) i.p.) inhibited neurogenic plasma extravasation evoked by 1% mustard oil and non-neurogenic oedema induced by 5% dextran in the rat skin. 2. Cyclic synthetic octapeptide (TT-248 and TT-250) and heptapeptide (TT-232) somatostatin analogues proved to be more effective in reducing neurogenic and non-neurogenic inflammatory reactions but octreotide had no influence on either neurogenic or non-neurogenic inflammation. 3. TT-232 administered i.p. or i.v. (1.06âââ42.40ânmolâkg(â1)) inhibited in a dose-dependent manner the plasma extravasation evoked by mustard oil in the rat's paw. Neither diclofenac (15.78âââ315.60âÎŒmolâkg(â1)) nor the selective COX-2 inhibitor meloxicam (2.95âââ569.38âÎŒmolâkg(â1)) attenuated the mustard oil-induced neurogenic plasma extravasation. 4. TT-232, diclofenac and meloxicam dose-dependently diminished non-neurogenic dextran-oedema of the paw the ED(35) values were 1.73ânmolâkg(â1) for TT-232 and 34.37âÎŒmolâkg(â1) for diclofenac. 5. TT-232 inhibited in the dose range of 1.06âââ21.21ânmolâkg(â1) the bradykinin-induced plasma extravasation in the skin of the chronically denervated paw. 6. Mustard oil-induced cutaneous plasma extravasation was dose-dependently diminished by s.c. TT-232 1, 2, 4, 6 or 16âh after the treatment. TT-232 (2Ă106, 2Ă212 and 2Ă530ânmolâkg(â1) per day s.c. for 18 days) caused dose-dependent inhibition of chronic Freund adjuvant-induced arthritis during the experimental period. 7. TT-232 (200 and 500ânM) inhibited the release of SP, CGRP and somatostatin from the rat isolated trachea induced by electrical field stimulation (40âV, 0.1âms, 10âHz, 120âs) or by capsaicin (10(â7)âM), but did not influence the basal, non-stimulated peptide release. 8. It is concluded that somatostatin analogues without endocrine functions as TT-232 are promising compounds with a novel site of action for inhibition of non-neurogenic and neurogenic inflammatory processes