Vnímání klimatu školy pedagogy 1. stupně ZŠ

Tato závěrečná práce se zabývá vnímáním školního klimatu na prvním stupni základní školy z pohledu pedagogů. Práce má teoretickou a praktickou část. Teoretická část se zabývá poznatky souvisejícími s klimatem. Jsou zde zmíněny pojmy klima školy, klima třídy, prostředí a atmosféra. Také jsou uváděny faktory, které bezprostředně klima školy ovlivňují. Cílem výzkumného šetření je zjistit, jak vnímají klima školy, a to jak reálné, tak ideální pedagogové 1. stupně ZŠ venkovského typu. Výzkumné šetření bude provedeno kvalitativně s využitím metody dotazování

Phê bình thơ Đường

300 tr.; 21 cm

Anti-inflammatory effect of synthetic somatostatin analogues in the rat

1. Somatostatin (6.11 nmol kg(−1) i.p.) inhibited neurogenic plasma extravasation evoked by 1% mustard oil and non-neurogenic oedema induced by 5% dextran in the rat skin. 2. Cyclic synthetic octapeptide (TT-248 and TT-250) and heptapeptide (TT-232) somatostatin analogues proved to be more effective in reducing neurogenic and non-neurogenic inflammatory reactions but octreotide had no influence on either neurogenic or non-neurogenic inflammation. 3. TT-232 administered i.p. or i.v. (1.06 – 42.40 nmol kg(−1)) inhibited in a dose-dependent manner the plasma extravasation evoked by mustard oil in the rat's paw. Neither diclofenac (15.78 – 315.60 μmol kg(−1)) nor the selective COX-2 inhibitor meloxicam (2.95 – 569.38 μmol kg(−1)) attenuated the mustard oil-induced neurogenic plasma extravasation. 4. TT-232, diclofenac and meloxicam dose-dependently diminished non-neurogenic dextran-oedema of the paw the ED(35) values were 1.73 nmol kg(−1) for TT-232 and 34.37 μmol kg(−1) for diclofenac. 5. TT-232 inhibited in the dose range of 1.06 – 21.21 nmol kg(−1) the bradykinin-induced plasma extravasation in the skin of the chronically denervated paw. 6. Mustard oil-induced cutaneous plasma extravasation was dose-dependently diminished by s.c. TT-232 1, 2, 4, 6 or 16 h after the treatment. TT-232 (2×106, 2×212 and 2×530 nmol kg(−1) per day s.c. for 18 days) caused dose-dependent inhibition of chronic Freund adjuvant-induced arthritis during the experimental period. 7. TT-232 (200 and 500 nM) inhibited the release of SP, CGRP and somatostatin from the rat isolated trachea induced by electrical field stimulation (40 V, 0.1 ms, 10 Hz, 120 s) or by capsaicin (10(−7) M), but did not influence the basal, non-stimulated peptide release. 8. It is concluded that somatostatin analogues without endocrine functions as TT-232 are promising compounds with a novel site of action for inhibition of non-neurogenic and neurogenic inflammatory processes