Laparoscopic Gastrectomy for Gastric Cancer with Peritoneal Dissemination after Induction Chemotherapy

Gastric cancer with peritoneal dissemination may be diagnosed as unresectable. More recently, as a result of progress in chemotherapy, some patients with peritoneal dissemination have exhibited extended survival. We report on our experience with three patients in whom induction chemotherapy allowed for totally laparoscopic total gastrectomy (TLTG). All three patients were diagnosed as having advanced gastric cancer with peritoneal dissemination using staging laparoscopy. As induction chemotherapy, S-1 combined with cisplatin was administered to two patients and trastuzumab plus capecitabine combined with cisplatin to one patient. TLTG was performed in all patients and there were no postoperative complications. Adjuvant chemotherapy was initiated within 3 weeks after surgery in all three patients. Laparoscopic gastrectomy undertaken after induction chemotherapy was found to be effective and safe; this treatment has the potential to achieve good treatment outcomes in patients with stage IV gastric cancer

Semiclassical instability of the brane-world: Randall-Sundrum bubbles

We discuss the semiclassical instability of the Randall-Sundrum brane-world model against a creation of a kind of Kaluza-Klein bubble. An example describing such a bubble space-time is constructed from the five-dimensional AdS-Schwarzschild metric. The induced geometry of the brane looks like the Einstein-Rosen bridge, which connects the positive and the negative tension branes. The bubble rapidly expands and there also form a trapped region around it.Comment: 4 pages, 3 figures, two references adde

Slicing and Brane Dependence of the (A)dS/CFT Correspondence

We investigate the slicing dependence of the relationship between conserved quantities in the (A)dS/CFT correspondence. Specifically, we show that the Casimir energy depends upon the topology and geometry of spacetime foliations of the bulk near the conformal boundary. We point out that the determination of the brane location in brane-world scenarios exhibits a similar slicing dependence, and we comment on this in the context of the AdS/CFT correspondence conjecture.Comment: latex, 6 pages, minor changes in wording, reference adde

High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A

Methylglyoxal is a highly reactive dicarbonyl degradation product formed from triose phosphates during glycolysis. Methylglyoxal forms stable adducts primarily with arginine residues of intracellular proteins. The biologic role of this covalent modification in regulating cell function is not known. Here we report that in mouse kidney endothelial cells, high glucose causes increased methylglyoxal modification of the corepressor mSin3A. Methylglyoxal modification of mSin3A results in increased recruitment of O-GlcNAc-transferase, with consequent increased modification of Sp3 by O-linked N-acetylglucosamine. This modification of Sp3 causes decreased binding to a glucose-responsive GC-box in the angiopoietin-2 (Ang-2) promoter, resulting in increased Ang-2 expression. Increased Ang-2 expression induced by high glucose increased expression of intracellular adhesion molecule 1 and vascular cell adhesion molecule 1 in cells and in kidneys from diabetic mice and sensitized microvascular endothelial cells to the proinflammatory effects of tumor necrosis factor alpha. This novel mechanism for regulating gene expression may play a role in the pathobiology of diabetic vascular disease

RS1 Cosmology as Brane Dynamics in an AdS/Schwarzschild Bulk

We explore various facets of the cosmology of the Randall-Sundrum scenario with two branes by considering the dynamics of the branes moving in a bulk AdS/Schwarzschild geometry. This approach allows us both to understand in more detail and from a different perspective the role of the stabilization of the hierarchy in the brane cosmology, as well as to extend to the situation where the metric contains a horizon. In particular, we explicitly determine how the Goldberger-Wise stabilization mechanism perturbs the background bulk geometry to produce a realistic cosmology.Comment: 9 pages, uses ReVTeX, no figure

Brane-World and Holography

We consider the brane-world in the holographic point of view. Bearing the realistic models in mind, the bulk massless scalar field is introduced. First of all, we find the constraint on the coupling of the scalar fields with the matter(not holographic CFT) on the brane. We show that the traceless part of the energy-momentum tensor of holographic CFT is a part of the bulk Weyl tensor. The trace part which comes from the trace-anomaly is corresponding to the $\rho^2$-term appeared in the generalized FRW equation in the brane-world.Comment: 4 pages, minor change

Uniqueness and non-uniqueness of static vacuum black holes in higher dimensions

We prove the uniqueness theorem for asymptotically flat static vacuum black hole solutions in higher dimensional space-times. We also construct infinitely many non-asymptotically flat regular static black holes on the same spacetime manifold with the same spherical topology.Comment: to appear in Progress of Theoretical Physics Supplement No. 14

Anti-de Sitter no-hair, AdS/CFT and the brane-world

We study the asymptotic behavior of the bulk spacetimes with the negative cosmological constant in the context of the brane-world scenario. We show that, in Euclidean bulk, or in Lorentzian static bulk, some sequences of hypersurfaces with the positive Ricci scalar evolve to the warped geometries like the anti-de Sitter spacetime. Based on the AdS/CFT correspondence, we discuss that the positivity of the Ricci scalar is related to the stability of CFT on the brane. In addition, the brane-world is described from the holographic point of view. The asymptotic local structure of the conformal infinity is also investigated.Comment: 6 pages, minor changes, to appear in Phys. Rev.

D-braneworld cosmology

We discuss D-braneworld cosmology, that is, the brane is described by the Born-Infeld action. Compared with the usual Randall-Sundrum braneworld cosmology where the brane action is the Nambu-Goto one, we can see some drastic changes at the very early universe: (i)universe may experience the rapid accelerating phase (ii)the closed universe may avoid the initial singularity. We also briefly address the dynamics of the cosmology in the open string metric, which might be favorer than the induced metric from the view point of the D-brane.Comment: 6 pages, 3 figures, minor corrections, accepted for publication in Phys. Rev.

Effective theory for close limit of two branes

We discuss the effective theory for the close limit of two branes in a covariant way. To do so we solve the five dimensional Einstein equation along the direction of the extra dimension. Using the Taylor expansion we solve the bulk spacetimes and derive the effective theory describing the close limit. We also discuss the radion dynamics and braneworld black holes for the close limit in our formulation.Comment: 6 pages, a version to be published in Phy.Rev.