662 research outputs found
Multiple abnormalities in the skull of a prostitute. An autopsy report (1900)
OBJECTIVE: The study presents and comments on the publication of an autopsy report. CASE REPORT: In 1900 De Blasio published an article entitled "Multiple abnormalities in a prostitute's skull" in the "Journal of Psychiatry, Criminal Anthropology and related sciences". In this work De Blasio related anomalies at the cranial level to the presence of mental pathologies. The skull belonged to a 24-year-old prostitute who died of syphilitic hepatitis. In his article, De Blasio described the life of the woman, after which he gave a macroscopic description of the skull. De Blasio believed that the subject's amoral behavior was caused by the anomalous shape of the subject's skull. CONCLUSION: From the study, it is evident that the school of criminal anthropology influenced De Blasio's autopsy medical practice, and it is interesting to note the interpretation of anthropologists of the time who tried to describe the link between physical and behavioral anomalies
Event-triggered control systems under denial-of-service attacks
In this paper, we propose a systematic design framework for output-based dynamic event-triggered control (ETC) systems under Denial-of-Service (DoS) attacks. These malicious DoS attacks are intended to interfere with the communication channel causing periods in time at which transmission of measurement data is impossible. We show that the proposed ETC scheme, if well designed, can tolerate a class of DoS signals characterized by frequency and duration properties without jeopardizing the stability, performance and Zeno-freeness of the ETC system. In fact, the design procedure of the ETC condition allows trade-offs between performance, robustness to DoS attacks and utilization of communication resources. The main results will be illustrated by means of a numerical example
Reconstructing the Density of States by History-Dependent Metadynamics
We present a novel method for the calculation of the energy density of states
D(E) for systems described by classical statistical mechanics. The method
builds on an extension of a recently proposed strategy that allows the free
energy profile of a canonical system to be recovered within a pre-assigned
accuracy,[A. Laio and M. Parrinello, PNAS 2002]. The method allows a good
control over the error on the recovered system entropy. This fact is exploited
to obtain D(E) more efficiently by combining measurements at different
temperatures. The accuracy and efficiency of the method are tested for the
two-dimensional Ising model (up to size 50x50) by comparison with both exact
results and previous studies. This method is a general one and should be
applicable to more realistic model systems
RNA denaturation: excluded volume, pseudoknots and transition scenarios
A lattice model of RNA denaturation which fully accounts for the excluded
volume effects among nucleotides is proposed. A numerical study shows that
interactions forming pseudoknots must be included in order to get a sharp
continuous transition. Otherwise a smooth crossover occurs from the swollen
linear polymer behavior to highly ramified, almost compact conformations with
secondary structures. In the latter scenario, which is appropriate when these
structures are much more stable than pseudoknot links, probability
distributions for the lengths of both loops and main branches obey scaling with
nonclassical exponents.Comment: 4 pages 3 figure
The economic implications of HLA matching in cadaveric renal transplantation.
Abstract
Background: The potential economic effects of the allocation of cadaveric kidneys on the basis of tissue-matching criteria are controversial. We analyzed the economic costs associated with the transplantation of cadaveric kidneys with various numbers of HLA mismatches and examined the potential economic benefits of a local, as compared with a national, system designed to minimize HLA mismatches between donor and recipient in first cadaveric renal transplantations. Methods: All data were supplied by the U.S. Renal Data System. Data on all payments made by Medicare from 1991 through 1997 for the care of recipients of a first cadaveric renal transplant were analyzed according to the number of HLA-A, B, and DR mismatches between donor and recipient and the duration of cold ischemia before transplantation. Results: Average Medicare payments for renal-transplant recipients in the three years after transplantation increased from 80,807 for kidneys with six HLA mismatches between donor and recipient, a difference of 34 percent (P\u3c0.001). By three years after transplantation, the average Medicare payments were 74,997 for those with more than 36 hours (P\u3c0.001). In simulations, the assignment of cadaveric kidneys to recipients by a method that minimized HLA mismatching within a local geographic area (i.e., within one of the approximately 50 organ-procurement organizations, which cover widely varying geographic areas) produced the largest cost savings ($4,290 per patient over a period of three years) and the largest improvements in the graft-survival rate (2.3 percent) when the potential costs of longer cold-ischemia time were considered. Conclusions: Transplantation of better-matched cadaveric kidneys could have substantial economic advantages. In our simulations, HLA-based allocation of kidneys at the local level produced the largest estimated cost savings, when the duration of cold ischemia was taken into account. No additional savings were estimated to result from a national allocation program, because the additional costs of longer cold-ischemia time were greater than the advantages of optimizing HLA matching
On the size of knots in ring polymers
We give two different, statistically consistent definitions of the length l
of a prime knot tied into a polymer ring. In the good solvent regime the
polymer is modelled by a self avoiding polygon of N steps on cubic lattice and
l is the number of steps over which the knot ``spreads'' in a given
configuration. An analysis of extensive Monte Carlo data in equilibrium shows
that the probability distribution of l as a function of N obeys a scaling of
the form p(l,N) ~ l^(-c) f(l/N^D), with c ~ 1.25 and D ~ 1. Both D and c could
be independent of knot type. As a consequence, the knot is weakly localized,
i.e. ~ N^t, with t=2-c ~ 0.75. For a ring with fixed knot type, weak
localization implies the existence of a peculiar characteristic length l^(nu) ~
N^(t nu). In the scaling ~ N^(nu) (nu ~0.58) of the radius of gyration of the
whole ring, this length determines a leading power law correction which is much
stronger than that found in the case of unrestricted topology. The existence of
such correction is confirmed by an analysis of extensive Monte Carlo data for
the radius of gyration. The collapsed regime is studied by introducing in the
model sufficiently strong attractive interactions for nearest neighbor sites
visited by the self-avoiding polygon. In this regime knot length determinations
can be based on the entropic competition between two knotted loops separated by
a slip link. These measurements enable us to conclude that each knot is
delocalized (t ~ 1).Comment: 29 pages, 14 figure
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