176 research outputs found
Analysis of IEEE 802.11N-like transmission techniques with and without prior CSI for video applications
Towards the second order adaptation in the next generation remote patient management systems
Remote Patient Management (RPM) systems are expected to be increasingly important for chronic disease management as they facilitate monitoring vital signs of patients at their home, alerting the care givers in case of worsening. They also provide patients with educational content. RPM systems collect a lot of (different types of) data about patients, providing an opportunity for personalizing information services. In our recent work we highlighted the importance of using available information for personalization and presented a possible next generation RPM system that enables personalization of educational content and its delivery to patients. We introduced a generic methodology for personalization and emphasized the role of knowledge discovery (KDD). In this paper we focus on the necessity of the second-order adaptation mechanisms in the RPM systems to address the challenge of continuous on-line (re)learning of actionable patterns from the patient data
Heart failure hospitalization prediction in remote patient management systems
Healthcare systems are shifting from patient care in hospitals to monitored care at home. It is expected to improve the quality of care without exploding the costs. Remote patient management (RPM) systems offer a great potential in monitoring patients with chronic diseases, like heart failure or diabetes. Patient modeling in RPM systems opens opportunities in two broad directions: personalizing information services, and alerting medical personnel about the changing conditions of a patient. In this study we focus on heart failure hospitalization (HFH) prediction, which is a particular problem of patient modeling for alerting. We formulate a short term HFH prediction problem and show how to address it with a data mining approach. We emphasize challenges related to the heterogeneity, different types and periodicity of the data available in RPM systems. We present an experimental study on HFH prediction using, which results lay a foundation for further studies and implementation of alerting and personalization services in RPM systems
Towards the Second-Order Adaptation in the Next Generation Remote Patient Management Systems
Remote Patient Management (RPM) systems are expected to be increasingly important for chronic disease management as they facilitate monitoring vital signs of patients at their home, alerting the care givers in case of worsening. They also provide patients with educational content. RPM systems collect a lot of (different types of) data about patients, providing an opportunity for personalizing information services. In our recent work we highlighted the importance of using available information for personalization and presented a possible next generation RPM system that enables personalization of educational content and its delivery to patients. We introduced a generic methodology for personalization and emphasized the role of knowledge discovery (KDD). In this paper we focus on the necessity of the second-order adaptation mechanisms in the RPM systems to address the challenge of continuous on-line (re)learning of actionable patterns from the patient data.
Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase (TK) contributes to the pathogenesis and development of resistance to ABL-TK inhibitors (TKI). The PI3K pathway thus is an attractive therapeutic target in BCR-ABL positive leukemias, but its role in BCR-ABL negative ALL is conjectural. Moreover, the functional contribution of individual components of the PI3K pathway in ALL has not been established.
Experimental design: We compared the activity of the ATP-competitive pan-PI3K inhibitor NVP-BKM120, the allosteric mTORC1 inhibitor RAD001, the ATP-competitive dual PI3K/mTORC1/C2 inhibitors NVP-BEZ235 and NVP-BGT226 and the combined mTORC1 and mTORC2 inhibitors Torin 1, PP242 and KU-0063794 using long-term cultures of ALL cells (ALL-LTC) from patients with B-precursor ALL that expressed the BCR-ABL or TEL-ABL oncoproteins or were BCR-ABL negative.
Results: Dual PI3K/mTOR inhibitors profoundly inhibited growth and survival of ALL cells irrespective of their genetic subtype and their responsiveness to ABL-TKI. Combined suppression of PI3K, mTORC1 and mTORC2 displayed greater antileukemic activity than selective inhibitors of PI3K, mTORC1 or mTORC1 and mTORC2.
Conclusions: Inhibition of the PI3K/mTOR pathway is a promising therapeutic approach in patients with ALL. Greater antileukemic activity of dual PI3K/mTORC1/C2 inhibitors appears to be due to the redundant function of PI3K and mTOR. Clinical trials examining dual PI3K/mTORC1/C2 inhibitors in patients with B-precursor ALL are warranted, and should not be restricted to particular genetic subtypes
Irreversible Magnetization Deep in the Vortex-Liquid State of a 2D Superconductor at High Magnetic Fields
The remarkable phenomenon of weak magnetization hysteresis loops, observed
recently deep in the vortex-liquid state of a nearly two-dimensional (2D)
superconductor at low temperatures, is shown to reflect the existence of an
unusual vortex-liquid state, consisting of collectively pinned crystallites of
easily sliding vortex chains.Comment: 5 pages, 4 figure
Existence of the Abrikosov vortex state in two-dimensional type-II superconductors without pinning
Theory alternative to the vortex lattice melting theories is advertised. The
vortex lattice melting theories are science fiction cond-mat/9811051 because
the Abrikosov state is not the vortex lattice with crystalline long-range
order. Since the fluctuation correction to the Abrikosov solution is infinite
in the thermodynamic limit (K.Maki and H.Takayama, 1972) any fluctuation theory
of the mixed state should consider a superconductor with finite sizes. Such
nonperturbative theory for the easiest case of two-dimensional superconductor
in the lowest Landau level approximation is presented in this work. The
thermodynamic averages of the spatial average order parameter and of the
Abrikosov parameter are calculated. It is shown that the position
H_{c4} of the transition into the Abrikosov state (i.e. in the mixed state with
long-range phase coherence) depends strongly on sizes of two-dimensional
superconductor. Fluctuations eliminate the Abrikosov vortex state in a wide
region of the mixed state of thin films with real sizes and without pinning
disorders, i.e. H_{c4} << H_{c2}. The latter has experimental corroboration in
Phys.Rev.Lett. 75, 2586 (1995).Comment: 4 pages, 0 figure
Interlayer pair tunneling and gap anisotropy in YBaCuO
Recent ARPES measurement observed a large -axis gap anisotropy,
, in clean YBaCuO. This
indicates that some sub-dominant component may exist in the -wave
dominant gap. We propose that the interlayer pairing tunneling contribution can
be determined through the investigation of the order parameter anisotropy.
Their potentially observable features in transport and spin dynamics are also
studied.Comment: 4 pages, 3 figure
Two Pseudogaps in the Cuprates: Meingast et al. Reply
In classical superconductors Cooper-pair formation and phase coherence occur
simultaneously as the temperature is lowered below Tc. In high-temperature
superconductors (HTSC), on the other hand, the small superfluid density and low
associated phase stiffness of the superconducting condensate are expected to
lead to a separation of the Cooper-pair formation and the phase-coherence
temperatures, especially in underdoped materials [3]. The only real phase
transition in this scenario is the 3d-XY phase-ordering transition at Tc [3,4].
In our Letter [2] we showed that Tc in underdoped and optimally doped YBCO is
just such a phase-ordering temperature, and then the question naturally arises
- where do the Cooper pairs form? The observed 3d-XY scaling of our thermal
expansion data over a wide temperature range [2] suggests that pairing occurs
at temperatures considerably above Tc, and it thus appeared quite natural for
us to associate the opening of the pseudogap at T*.Comment: 3 pages, 1 Figure (Reply to Comment by R. S. Markiewicz, Phys. Rev.
Lett. 89, 229703 (2002
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