Remote Patient Management (RPM) systems are expected to be increasingly important for chronic disease management as they facilitate monitoring vital signs of patients at their home, alerting the care givers in case of worsening. They also provide patients with educational content. RPM systems collect a lot of (different types of) data about patients, providing an opportunity for personalizing information services. In our recent work we highlighted the importance of using available information for personalization and presented a possible next generation RPM system that enables personalization of educational content and its delivery to patients. We introduced a generic methodology for personalization and emphasized the role of knowledge discovery (KDD). In this paper we focus on the necessity of the second-order adaptation mechanisms in the RPM systems to address the challenge of continuous on-line (re)learning of actionable patterns from the patient data
