Incidence of Hypophosphatemia after Ferric Carboxymaltose Treatment: Single Center Experience

Aim:The aim of this study was to evaluate the incidence of hypophosphatemia after ferric carboxymaltose (FCM) infusion and the factors affecting hypophosphatemia.Materials and Methods:Ninety-two patients who received FCM treatment for iron deficiency anemia (IDA) were included in the study. Phosphorus, calcium, magnesium, 25-hydroxy vitamin D, and parathyroid hormone levels before and after FCM infusion were obtained from the medical records. Hypophosphatemia was defined as serum phosphorus level of <2.5 mg/dL and severe hypophosphatemia as <1 mg/dL. The cut-off value for baseline phosphorus in predicting hypophosphatemia was detected as 3.4 mg/mL with the ROC analysis.Results:Seventy-seven of the patients were women. The mean age was 47.5±15.5 (18-85) years. Thirty of the patients (32.6%) were given 500 mg iron as FCM and 62 patients (67.4%) were given 1000 mg iron as FCM. The level of serum phosphorus measured 10-14 days after FCM was determined lower than the baseline level (2.22±0.57 mg/dL vs 3.34±0.39 mg/dL, p<0.000). Hypophosphatemia was observed in 62 patients (67.4%) after FCM infusion. Severe hypophosphatemia was seen in only 2 patients (2.1%). Patients given a dose of 1000 mg FCM had a higher incidence of hypophosphatemia compared to those given 500 mg FCM (75.8% vs 50%, p=0.013). Baseline phosphorus level of 3.4 mg/dL was associated with an increased risk of developing hypophosphatemia with an odds ratio of 9.2 (p=0.001; 95% confidence interval: 3.41-25.21). On logistic Independentregression analysis, it was found that baseline phosphorus level and a dose of 1000 mg FCM were independent risk factors for the development of hypophosphatemia.Conclusion:The incidence of hypophosphatemia due to FCM in our study was consistent with the literature. When FCM treatment is given to patients with IDA, the patients should be evaluated according to their baseline phosphorus level, the dose of FCM and frequency of administration, and it should be kept in mind to follow the phosphorus level in patients with risk for hypophosphatemia

Besin Alerjisi Olan 0-2 Yaş Çocukların Annelerinde Anksiyete ve Bakım Veren Külfetinin Değerlendirilmesi

Amaç: Besin alerjisi olan hastalar ve aileleri sağlıklı bireylere göre düşük yaşam kalitesi, anksiyete, depresyon ve strese sahip olup, ebeveynlerde bakım veren külfeti yüksektir. Çalışmamızda 0-2 yaş arası gıda alerjisi hastalarının annelerine eşlik edebilecek anksiyete bozukluğunun değerlendirilmesi ve gıda alerjisi olan hastaların annelerinde külfetin incelenmesi amaçlandı. Gereç ve Yöntem: Gıda alerjisi olan 0-2 yaş arası çocukların annelerine ve kontrol grubu olarak sağlıklı çocukların annelerine sosyodemografik veriler, Hastane Anksiyete ve Depresyon Ölçeği (HADÖ), Psikolojik Belirti Tarama Listesi (SCL 90-R) ve Zarit Bakıcı Yükü Ölçeği ile ilgili anket uygulandı. Bulgular: Çalışmaya gıda alerjisi olan 67 çocuk annesi ve sağlıklı çocuğu olan 74 anne alındı. Zarit Bakım Veren Külfet Ölçeği puanı, gıda alerjisi olan çocukların annelerinde sağlıklı çocukların annelerine göre anlamlı olarak daha yüksekti (p=0,018). Besin alerjisi olan çocukların anneleri, genel SCL 90-R ölçeğinde anlamlı olarak daha yüksek bir genel puana sahipti (p=0,045). Besin alerjisi olan çocukların annelerinde HADÖ puanı anlamlı olarak yüksekken, Hastane Depresyon Ölçeği puanında fark yoktu (sırasıyla p=0,045, p=0,825). Sonuç: Annelerin külfet, anksiyete, depresyon gibi duygusal durumlarının değerlendirilmesi ve besin alerjisi ile baş etmeye çalışma stratejileri ihmal edilebilir. Bu nedenle besin alerjisi olan özellikle küçük yaştaki çocukların annelerinin psikososyal destek gereksinimleri değerlendirilmeli ve gerekli yönlendirme sağlanmalıdır

19.yüzyılda Ayvalık'ta zeytinyağı sanayi ve yerleşim dokusuna etkisi.

Ayvalık which is located on the Aegean coast of the West Anatolia made its main breakthrough in the 19th century and owe this development to olive oil production which was the main economic input of the settlement since the establishment of Ayvalık. Ayvalık was within the hinterland of İzmir which was gained importance as a regional trade centre in the 19th century. Thus, Ayvalık found the way to improve its trade relations in an international level and eventually increase its olive oil production volume due to the growing demands. The new form of olive oil production; factories, developed together with the traditional house and workshop productions in the last quarter of the 19th century in Ayvalık. These three forms of production made up the second significant usage within the Ayvalık after the residential areas. The two or more floored, large volumed buildings were especially located on the shore, near to the port and trade facilities, on a flat terrain and became the most dominant and attractive buildings of the settlement. Besides the impressive industrial buildings, olive oil production itself effected the settlement pattern of Ayvalık. The main transportation axes were formed accordingly to the relationship between raw material areas and production places. The olive oil production also has an effect on the physical development direction of the settlement. The areas influenced from the negative effects of the production i.e., smell and dust were not chosen for development. The development of industrial buildings also blocked the physical relationship between the residential areas and sea. The industrial buildings such as factories, workshops and warehouses along the coast line reflect the industrial character of Ayvalık in the settlement’s silhouette.M.S. - Master of Scienc

Pure leydig cell tumour of the ovary in a post-menopausal patient with severe hyperandrogenism and erythrocytosis

A 60-year-old woman, presented with hirsutism, male pattern baldness, deepening voice and plethora over the past 5 years. Hormonal evaluation showed markedly elevated scrum testosterone level (> 1600 ng/dl) and oestradiol level (220 pg/ml) normal DHEA-SO4 level with suppressed LH and FSH levels. She had markedly erythrocytosis with normal hematological indices. The diagnosis of probable secondary erythrocytosis was made. Trans abdominal ultrasound and CT scan revealed a 14 cm x 11 cm x 9 cm solid pelvic mass. An ovarian androgen secreting tumour was suspected and surgery was performed. Histological examination showed a leydig cell tumour. After the operation testosterone and haematocrit levels returned to normal with regression of clinical symptoms. This is the first case of a leydig cell tumour with an erythropoietic effect of excess testosterone

Diffusion-weighted imaging findings of brain parenchyma in pediatric pseudotumor cerebri

Pseudotumor cerebri (PTC) or idiopathic intracranial hypertension (IIH) is a confounding clinical entity encompassing a variety of assumed mechanisms. The chief aim of the study was to determine brain edema by documenting the findings of diffusion magnetic resonance imaging (MRI) conducted to evaluate the brain parenchyma in patients with pediatric PTC. In this study, 19 patients participated, which were categorized into 2 groups as per Friedmans criteria. First group comprised of 11 patients diagnosed with PTC while the second group comprised of remaining 8 patients diagnosed with probable PTC. Conventional MRI findings and magnetic resonance venography (MRV) findings were noted. Transverse sinus variations were grouped according to the modified Fofi criteria. The apparent diffusion coefficient (ADC) values (ADC mean, ADC min, and ADC max) of the splenium and genu of the corpus callosum, bilateral occipital, parietal, temporal, and frontal cortex and white matter along with the bilateral head of caudate nucleus, putamen and thalamus were evaluated. The control group was formed with corresponding ages and gender of the patients and the ADC values (ADC mean, ADC min, and ADC max) for brain parenchyma in same localisations of the brain were also evaluated in controls. The findings showed that there is no statistically significant difference between two groups of patients regarding their ages (p: 0.06). The mean cerebrospinal fluid (CSF) opening pressure was found to be 35.5 ± 9.0 cmH2O and 25.5 ± 2.8 cmH2O for first and second group respectively with significant difference (p &lt; 0.001). Headache was found to be the most common symptom (50%) followed by double vision (30%). The most common conventional MRI finding was perioptic nerve sheath distension (37%). 52% children had transverse sinus hypoplasia demonstrated by MRV. The ADC values (ADC mean, ADC min, and ADC max) for brain parenchyma evaluated in various regions for the groups and controls did not show any significant difference. The detection of a high percentage of the transverse sinus variations in patients with PTC supports the finding that PTC is accompanied by secondary obstruction of the transverse sinuses. The cerebral ADC values did not differ between age and gender matched control groups, showing there is no detectable cerebral edema in PTC with diffusion MRI. [Med-Science 2022; 11(1.000): 90-7

Energy investment planning at a private company: a mathematical programming-based model and its application in Turkey

Semra Ağralı (MEF Author)We consider a mid-sized private electricity generating company that plans to enter the market that is partially regulated. There is a cap and trade system in operation in the industry. There are nine possible power plant types that the company considers to invest on through a planning horizon. Some of these plants may include a carbon capture and storage technology. We develop a stochastic mixed-integer linear program for this problem where the objective is to maximize the expected net present value of the profit obtained. We include restrictions on the maximum and minimum possible amount of investment for every type of investment option. We also enforce market share conditions such that the percentage of the total investments of the company over the total installed capacity of the country stay between upper and lower bounds. Moreover, in order to distribute the investment risk, the percentage of each type of power plant investment is restricted by some upper bound. We tested the model for a hypothetical company operating in Turkey. The results show that the model is suitable to be used for determining the investment strategy of the company.WOS:000413247800003Scopus - Affiliation ID: 60105072Science Citation Index Expanded - Social Sciences Citation IndexQ1ArticleUluslararası işbirliği ile yapılmayan - HAYIRKasım2017YÖK - 2017-1

Topical Steroid Phobia Among Mothers of Children with Atopic Dermatitis

Objective: Adherence to topical corticosteroids (TCS) is essential for the effective treatment of atopic dermatitis but some families have fears and concerns about TCS phobia. In this study, it was aimed to investigate the knowledge, opinions and fear about topical steroids among mothers of patients who used topical steroid therapy for their atopic dermatitis (AD) and its effect on drug compliance and disease severity

Engineered Iron Nanoparticles via Green Routes and Their Applications for Textile Wastewater Treatment

Textile wastewaters are characterized by high chemical oxygen demand (COD) concentration, strong color, high pH and temperature, and low biodegradability. Conventional treatment methods are considered to be inefficient to comply with the discharge limits. Recently, nano zero-valent iron (nZVI) technology has received increasing attention of the scientific community as an emerging technology for treatment of polluted streams. Due to smaller particle size, larger surface area and higher surface reactivity of iron nanoparticles, the removal of pollutants occur very rapidly. In this work, we synthesized nZVI employing green chemistry principles in a chemical reduction reaction. Iron precursor solution (FeSO4) was reduced by plant extracts that contain polyphenols. Plant polyphenols are known to possess strong reducing agent properties and act as effective metal chelators. The objective of this study was to characterize the green synthesized iron nanoparticles in terms of size and zeta potential parameters under various synthesis conditions (pH, precursor concentration and precursor/extract volume ratio) and compare the reactivity of the engineered nanoparticles for textile wastewater treatment. Green tea leaves-GT and Rose leaves-R were selected as the plant sources. Plant extracts were examined in terms of their Total Phenolic Content (TPC) expressed as Gallic Acid Equivalent (GAE). Rose leaves were found to possess 2062 mg/L TPC whereas, Green Tea leaves were found to have 1882 mg/L in grinded powder form. Results showed that 74% color removal along with 18% TOC removal could be achieved with 5 ppm of GT-ZVI nanoparticles synthesized at a 2/1 ratio (v/v) of precursor to extract. With the same concentration of R-ZVI nanoparticles, 78% color removal and 40% of TOC removal were observed