56 research outputs found
Steady State Entanglement in Cavity QED
We investigate steady state entanglement in an open quantum system,
specifically a single atom in a driven optical cavity with cavity loss and
spontaneous emission. The system reaches a steady pure state when driven very
weakly. Under these conditions, there is an optimal value for atom-field
coupling to maximize entanglement, as larger coupling favors a loss port due to
the cavity enhanced spontaneous emission. We address ways to implement
measurements of entanglement witnesses and find that normalized
cross-correlation functions are indicators of the entanglement in the system.
The magnitude of the equal time intensity-field cross correlation between the
transmitted field of the cavity and the fluorescence intensity is proportional
to the concurrence for weak driving fields.Comment: enhanced discussion, corrected formulas, title change, 1 added figur
Enhanced Spontaneous Emission Into The Mode Of A Cavity QED System
We study the light generated by spontaneous emission into a mode of a cavity
QED system under weak excitation of the orthogonally polarized mode. Operating
in the intermediate regime of cavity QED with comparable coherent and
decoherent coupling constants, we find an enhancement of the emission into the
undriven cavity mode by more than a factor of 18.5 over that expected by the
solid angle subtended by the mode. A model that incorporates three atomic
levels and two polarization modes quantitatively explains the observations.Comment: 9 pages, 2 figures, to appear in May 2007 Optics Letter
High flux cold Rubidium atomic beam for strongly coupled Cavity QED
This paper presents a setup capable of producing a high-flux continuous beam
of cold rubidium atoms for cavity QED experiments in the regime of strong
coupling. A 2 MOT, loaded by rubidium getters in a dry film coated vapor
cell, fed a secondary moving-molasses MOT (MM-MOT) at a rate of 1.5 x
atoms/sec. The MM-MOT provided a continuous beam with tunable velocity. This
beam was then directed through the waist of a 280 m cavity resulting in a
Rabi splitting of more than +/- 10 MHz. The presence of sufficient number of
atoms in the cavity mode also enabled splitting in the polarization
perpendicular to the input. The cavity was in the strong coupling regime, with
parameters (g, , )/2 equal to (7, 3, 6)/ 2 MHz.Comment: Journal pape
Extended calibration range for prompt photon emission in ion beam irradiation
Monitoring the dose delivered during proton and carbon ion therapy is still a
matter of research. Among the possible solutions, several exploit the
measurement of the single photon emission from nuclear decays induced by the
irradiation. To fully characterize such emission the detectors need
development, since the energy spectrum spans the range above the MeV that is
not traditionally used in medical applications. On the other hand, a deeper
understanding of the reactions involving gamma production is needed in order to
improve the physic models of Monte Carlo codes, relevant for an accurate
prediction of the prompt-gamma energy spectrum.This paper describes a
calibration technique tailored for the range of energy of interest and
reanalyzes the data of the interaction of a 80MeV/u fully stripped carbon ion
beam with a Poly-methyl methacrylate target. By adopting the FLUKA simulation
with the appropriate calibration and resolution a significant improvement in
the agreement between data and simulation is reported.Comment: 4 pages, 7 figures, Submitted to JINS
Multicenter phase II trial of preoperative induction chemotherapy followed by chemoradiation with docetaxel and cisplatin for locally advanced esophageal carcinoma (SAKK 75/02)
Background: This multicenter phase II study investigated the efficacy and feasibility of preoperative induction chemotherapy followed by chemoradiation and surgery in patients with esophageal carcinoma. Patients and methods: Patients with locally advanced resectable squamous cell carcinoma or adenocarcinoma of the esophagus received induction chemotherapy with cisplatin 75 mg/m2 and docetaxel (Taxotere) 75 mg/m2 on days 1 and 22, followed by radiotherapy of 45 Gy (25 Ă 1.8 Gy) and concurrent chemotherapy comprising cisplatin 25 mg/m2 and docetaxel 20 mg/m2 weekly for 5 weeks, followed by surgery. Results: Sixty-six patients were enrolled at eleven centers and 57 underwent surgery. R0 resection was achieved in 52 patients. Fifteen patients showed complete, 16 patients nearly complete and 26 patients poor pathological remission. Median overall survival was 36.5 months and median event-free survival was 22.8 months. Squamous cell carcinoma and good pathologically documented response were associated with longer survival. Eighty-two percent of all included patients completed neoadjuvant therapy and survived for 30 days after surgery. Dysphagia and mucositis grade 3/4 were infrequent (<9%) during chemoradiation. Five patients (9%) died due to surgical complications. Conclusions: This neoadjuvant, taxane-containing regimen was efficacious and feasible in patients with locally advanced esophageal cancer in a multicenter, community-based setting and represents a suitable backbone for further investigatio
Phase II study of capecitabine and oxaliplatin given prior to and concurrently with preoperative pelvic radiotherapy in patients with locally advanced rectal cancer
This multicentre phase II study evaluated the efficacy and safety of preoperative capecitabine plus oxaliplatin and radiotherapy (RT) in patients with locally advanced rectal cancer (T3/T4 rectal adenocarcinoma with or without nodal involvement). Treatment consisted of one cycle of XELOX (capecitabine 1000âmgâmâ2 bid on days 1â14 and oxaliplatin 130âmgâmâ2 on day 1), followed by RT (1.8âGy fractions 5 days per week for 5 weeks) plus CAPOX (capecitabine 825âmgâmâ2 bid on days 22â35 and 43â56, and oxaliplatin 50âmgâmâ2 on days 22, 29, 43 and 50). Surgery was recommended 5 weeks after completion of chemoradiotherapy. The primary end point was pathological complete tumour response (pCR). Sixty patients were enrolled. In the intent-to-treat population, the pCR rate was 23% (95% CI: 13â36%). 58 patients underwent surgery; R0 resection was achieved in 57 (98%) patients, including all 5 patients with T4 tumours. Sphincter preservation was achieved in 49 (84%) patients. Tumour and/or nodal downstaging was observed in 39 (65%) patients. The most common grade 3/4 adverse events were diarrhoea (20%) and lymphocytopaenia (43%). Preoperative capecitabine, oxaliplatin and RT achieved encouraging rates of pCR, R0 resection, sphincter preservation and tumour downstaging in patients with locally advanced rectal cancer
A modern network approach to revisiting the positive and negative affective schedule (PANAS) construct validity
Introduction: The factor structure of the Positive and Negative Affective Schedule (PANAS) is still a topic of debate. There are several reasons why using Exploratory Graph Analysis (EGA) for scale validation is advantageous and can help understand and resolve conflicting results in the factor analytic literature. Objective: The main objective of the present study was to advance the knowledge regarding the factor structure underlying the PANAS scores by utilizing the different functionalities of the EGA method. EGA was used to (1) estimate the dimensionality of the PANAS scores, (2) establish the stability of the dimensionality estimate and of the item assignments into the dimensions, and (3) assess the impact of potential redundancies across item pairs on the dimensionality and structure of the PANAS scores. Method: This assessment was carried out across two studies that included two large samples of participants. Results and Conclusion: In sum, the results are consistent with a two-factor oblique structure.Fil: Flores Kanter, Pablo Ezequiel. Universidad Empresarial Siglo XXI; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Garrido, Luis Eduardo. Pontificia Universidad CatĂłlica Madre y Maestra; RepĂșblica DominicanaFil: Moretti, Luciana SofĂa. Universidad Empresarial Siglo XXI; Argentina. Pontificia Universidad CatĂłlica Madre y Maestra; RepĂșblica Dominicana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Medrano, Leonardo. Universidad Empresarial Siglo XXI; Argentina. Pontificia Universidad CatĂłlica Madre y Maestra; RepĂșblica Dominicana. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentin
The effect of mechanical loading on osteogenesis of human dental pulp stromal cells in a novel in vitro model
Tooth loss often results in alveolar bone resorption because of lack of mechanical stimulation. Thus, the mechanism of mechanical loading on stem cell osteogenesis is crucial for alveolar bone regeneration. We have investigated the effect of mechanical loading on osteogenesis in human dental pulp stromal cells (hDPSCs) in a novel in vitro model. Briefly, 1 Ă 107 hDPSCs were seeded into 1 ml 3 % agarose gel in a 48-well-plate. A loading tube was then placed in the middle of the gel to mimic tooth-chewing movement (1 Hz, 3 Ă 30 min per day, n = 3). A non-loading group was used as a control. At various time points, the distribution of live/dead cells within the gel was confirmed by fluorescence markers and confocal microscopy. The correlation and interaction between the factors (e.g. force, time, depth and distance) were statistically analysed. The samples were processed for histology and immunohistochemistry. After 1-3 weeks of culture in the in-house-designed in vitro bioreactor, fluorescence imaging confirmed that additional mechanical loading increased the viable cell numbers over time as compared with the control. Cells of various phenotypes formed different patterns away from the reaction tube. The cells in the middle part of the gel showed enhanced alkaline phosphatase staining at week 1 but reduced staining at weeks 2 and 3. Additional loading enhanced Sirius Red and type I collagen staining compared with the control. We have thus successfully developed a novel in-house-designed in vitro bioreactor mimicking the biting force to enhance hDPSC osteogenesis in an agarose scaffold and to promote bone formation and/or prevent bone resorption
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