Cervical tubercular lymphadenitis accompanying with pulmonary tuberculosis – a case report

Tuberculosis (TB) is still one of the major public health problems worldwide. TB is an infectious disease caused by Mycobacterium tuberculosis. It typically affects the lungs (pulmonary tuberculosis), but may also occur in other sites (extrapulmonary tuberculosis). Cervical tubercular lymphadenitis is one of the most common localizations of extrapulmonary tuberculosis [1,2]. We present a case of a 57-year old man with a history of 3-month weakness and swollen, bilaterally inflamed cervical lymph nodes. Cervical tubercular lymphadenitis accompanying with pulmonary tuberculosis was diagnosed. Moreover, we carry out the differential diagnosis of the cervical lymphadenopathy

Hiccup as an uncommon symptom of pneumonia

Terlecka Paulina, Grzywa Celińska Anna, Emeryk Maksymiuk Justyna, Szmygin Milanowska Katarzyna, Milanowski Janusz. Hiccup as an uncommon symptom of pneumonia. Journal of Education, Health and Sport. 2017;7(12):111-117. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1108599 http://ojs.ukw.edu.pl/index.php/johs/article/view/5108 https://pbn.nauka.gov.pl/sedno-webapp/works/840705 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.11.2017. Revised: 15.11.2017. Accepted: 12.12.2017. Hiccup as an uncommon symptom of pneumonia Paulina Terlecka1, Anna Grzywa-Celińska1, Justyna Emeryk-Maksymiuk2, Katarzyna Szmygin-Milanowska1, Janusz Milanowski1 1 - Chair and Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, Poland 2 - Chair of Internal Medicine and Department of Internal Medicine in Nursing, Medical University of Lublin, Poland Corresponding author: Paulina Terlecka, MD Chair and Department of Pneumonology, Oncology and Allergology Medical University of Lublin 20-954 Lublin, Poland 8 Jaczewskiego St. phone number: +48817244431 fax number: +48817244823 e-mail: [email protected] Abstract Hiccup is a symptom resulting with uncontrolled contractions of the diaphragm and external intercostals muscles with inspiration and with simultaneous sudden closure of the glottis, that produces specific “hic” sound. Depending on the time of duration, hiccup can be classified as acute (up to 48h), chronic (48h to 1 month) and persistent (lasting longer than one month). The exact pathophysiology of this symptom still remains unknown, though it is well known, that short-term episodes of hiccup are mainly caused by oesophagus and stomach diseases (gastric and duodenal ulcers, gastritis, gastro-oesophageal reflux) or alcohol consumption. Other reasons of this phenomenon include the diseases with the stimulation of the vagus nerve or conditions with diaphragm irritation. It can be also psychogenic or resulting from central nervous system diseases. Short term episodes of hiccup happen to every person and do not cause any concern. Chronic hiccups can lead to significant worsening of quality of life including fatigue, nutritional restrictions, dehydration, weight loss, insomnia, respiratory disorders, depression or even suicidal thoughts. We present an interesting case with diagnostic and therapeutic procedures in a 65-year-old smoker, who was hospitalized in our Department because of pneumonia, with persistent hiccup as an additional complaint considerably deteriorating his quality of life. Key words: hiccup, symptom, pneumonia

Immunotherapy with pembrolizumab in a patient with advanced non-small-cell lung cancer with high PD-L1 expression and MET exon 14 splice site mutation: a case report

Lung cancer is one of the major oncological problems in Poland. Pembrolizumab monotherapy can be applied as first-line treatment in patients with advanced non-small-cell lung cancer (NSCLC) with the expression of programmed death ligand 1 (PD-L1) in ≥ 50% of tumor cells. The article presents a case report of a female patient with advanced lung adenocarcinoma and high PD-L1 expression and an additional MET exon 14 skipping mutation. Despite the advanced stage of the disease, the patient benefited spectacularly from pembrolizumab administered following stereotactic radiotherapy for central nervous system (CNS) metastases. Partial remission followed by long-term stabilization of the disease was achieved. Unfortunately, the therapy was discontinued due to grade-3 pulmonary toxicity observed after 3 years of treatment. Despite the discontinuation of the pembrolizumab therapy, the disease has currently been stabilized and inflammatory changes have slowly resolved upon administration of corticosteroid

Current dietary recommendations for patients with cystic fibrosis

Cystic fibrosis (CF) is classified as metabolic and multisystem disease with autosomal recessive inheritance caused by mutations in the gene located on chromosome 7 encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR is a transmembrane chloride channel of epithelial cells and affects the activity of the mucous membrane of the sweat glands, airway epithelium, pancreatic ducts, vas deferens, bile ducts and intestines. In CF, increased concentration of chlorides in the sweat, pancreatic insufficiency and impaired absorption are observed as well as changes in the respiratory system related to, among others, impaired airway patency, weakening of the mucociliary clearance mechanism and the development of bacterial infections. CF is a chronic condition requiring comprehensive therapy. Nutritional treatment is an essential element of CF therapy. Malnutrition is a common complication in patient with CF and eating disorders. The majority of patients with CF have higher energy, protein and fat needs. In addition, supplementation with enzyme preparations, vitamins, sodium chloride, as well as the use of high-energy nutrients is recommended. The aim of the study was to evaluate current nutritional recommendations of patients with CF

Different MET gene alterations in lung adenocarcinoma patients

Introduction. In this study, we attempted to detect selected abnormalities in the MET gene using various molecular techniques.  Material and methods. Twenty-six lung adenocarcinoma patients had a diagnosis of abnormalities in the genes: EGFR, ALK, ROS1, MET, and RET. They were diagnosed using various techniques and assessment of PD-L1 expression using immunohistochemistry. Copy number variation of MET gene was assessed by qPCR and FISH techniques, MET exon 14 mutation by RT-PCR method, and MET mRNA expression by the RT-qPCR technique. Statistical analyses were performed using Statistica v. 13.1 and MedCalc 15.8.  Results. Most patients (57.7%) had a high MET gene copy number in the qPCR method, which was not confirmed by the FISH method. A significant positive correlation (R = +0.573, p = 0.0022) between the MET gene copy number assessed with the qPCR method and the relative MET mRNA expression was found.  Conclusions. The positive correlation between the MET mRNA expression and the MET gene copy number in the qPCR test indicates that these methods could complement each other. The performance of these two tests simultaneously increases the reliability of the MET gene assessmen

Identification of priorities for public health in Poland on the basis of regional public health programs with special emphasis documents Podkarpackie Voivodeship

Niniejsza praca dotyczy problemu identyfikacji priorytetów zdrowia publicznego w Polsce, określonych w Narodowym Programie Zdrowia 2007-2015, stanowiących wskazówki i zalecenia dla instytucji rządowych i samorządowych w wyborze priorytetowych zadań jakie zostaną podjęte na rzecz ochrony zdrowia obywateli. Pierwszy rozdział pracy stanowi wprowadzenie do problematyki czynników warunkujących zdrowie, definiowania zdrowia publicznego a także podstawowych zadań jakie przypisywane są tej dziedzinie.W pracy została także podjęta próba zestawienia rozwiązań jakie podejmowane są przez pojedyncze państwa oraz przez organizacje międzynarodowe w zakresie Podstawowych Funkcji Zdrowia Publicznego. Część analityczną pracy stanowi badanie, przeprowadzone na podstawie danych z Podkarpackiego Centrum Zdrowia Publicznego, które wykazało wzrost liczby osób objętych działaniami podejmowanymi w ramach realizacji celów Narodowego Programu Zdrowia w roku 2011 w stosunku do roku poprzedniego. Niemniej jednak większość działań podejmowana jest w stopniu niewystarczającym za czym idzie brak efektów w poprawie stanu zdrowia mieszkańców województwa, a w niektórych przypadkach nawet jego pogorszenie.This work addresses the problem of identifying public health priorities in Poland, as defined in the National Health Programme 2007-2015, the guidance and recommendations to the government in the selection of priority tasks to be taken for the protection health of citizens. The first chapter of this work, is an introduction to issues determinants of health, the definition of public health as well as the basic tasks that are assigned to this area.This work was also made an attempt to combine solutions be made by panels individual countries and international organizations in the field of Essential Public Health Function.Some analytical work is a study conducted on the basis of data from the Podkarpackie Centre of Public Health, which showed growth in the number of persons covered activities under the objectives of the National Health Programme in 2011 compared to the previous year. However, most of the action taken is not sufficiently and consequently, no results in improving the health of inhabitants of the region, and in some cases even its deterioration

MET Gene Dysregulation as a Promising Therapeutic Target in Lung Cancer—A Review

Several molecular abnormalities in the MET gene have been identified, including overexpression, amplification, point mutations, and “skipping mutation” in exon 14. Even though deregulated MET signaling occurs rarely in non-small cell lung cancer (NSCLC), it possesses tumorigenic activity. Since the discovery of the significant role played by MET dysregulations in resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKI), many clinical trials have been focused on mechanisms underlying this acquired resistance. Therefore, new therapeutic strategies are being considered in the personalized therapy of NSCLC patients carrying MET abnormalities. First, MET kinase inhibitors (tepotinib and capmatinib) have been shown to be effective in the first and subsequent lines of treatment in NSCLC patients with “skipping mutations” in exon 14 of MET gene. In this article, the authors show the role of MET signaling pathway alterations and describe the results of clinical trials with MET inhibitors in NSCLC patients

<i>MET</i> Gene Dysregulation as a Promising Therapeutic Target in Lung Cancer—A Review

Several molecular abnormalities in the MET gene have been identified, including overexpression, amplification, point mutations, and “skipping mutation” in exon 14. Even though deregulated MET signaling occurs rarely in non-small cell lung cancer (NSCLC), it possesses tumorigenic activity. Since the discovery of the significant role played by MET dysregulations in resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKI), many clinical trials have been focused on mechanisms underlying this acquired resistance. Therefore, new therapeutic strategies are being considered in the personalized therapy of NSCLC patients carrying MET abnormalities. First, MET kinase inhibitors (tepotinib and capmatinib) have been shown to be effective in the first and subsequent lines of treatment in NSCLC patients with “skipping mutations” in exon 14 of MET gene. In this article, the authors show the role of MET signaling pathway alterations and describe the results of clinical trials with MET inhibitors in NSCLC patients

Recent Studies on Anti-Depressant Bioactive Substances in Selected Species from the Genera Hemerocallis and Gladiolus: A Systematic Review

Herbal therapy is a potential alternative applied to pharmacological alleviation of depression symptoms and treatment of this disorder, which is predicted by the World Health Organization (WHO) to be the most serious health problem worldwide over the next several years. It has been well documented that many herbs with psychotropic effects have far fewer side effects than a variety of pharmaceutical agents used by psychiatrists for the treatment of depression. This systematic review presents literature data on the antidepressant activity of representatives of the genera Hemerocallis (H. fulva and H. citrina Baroni, family Xanthorrhoeaceae) and Gladiolus (G. dalenii, family Iridaceae) and on biologically active compounds and their mechanisms of action to consider the application of herbal preparations supporting the treatment of depression

Immunoterapia pembrolizumabem u chorej na zaawansowanego niedrobnokomórkowego raka płuca z wysoką ekspresją PD-L1 i z obecnością mutacji miejsca splicingowego w eksonie 14 genu MET

Lung cancer is one of the major oncological problems in Poland. Pembrolizumab monotherapy can be applied as first-line treatment in patients with advanced non-small-cell lung cancer (NSCLC) with the expression of programmed death ligand 1 (PD-L1) in ≥ 50% of tumor cells. The article presents a case report of a female patient with advanced lung adenocarcinoma and high PD-L1 expression and an additional MET exon 14 skipping mutation. Despite the advanced stage of the disease, the patient benefited spectacularly from pembrolizumab administered following stereotactic radiotherapy for central nervous system (CNS) metastases. Partial remission followed by long-term stabilization of the disease was achieved. Unfortunately, the therapy was discontinued due to grade-3 pulmonary toxicity observed after 3 years of treatment. Despite the discontinuation of the pembrolizumab therapy, the disease has currently been stabilized and inflammatory changes have slowly resolved upon administration of corticosteroid.Rak płuca pozostaje jednym z głównych problemów onkologicznych w Polsce. Pembrolizumab w monoterapii może być stosowany w 1. linii leczenia u chorych na zaawansowanego niedrobnokomórkowego raka płuca z ekspresją PD-L1 na ≥ 50% komórek nowotworowych. W artykule przedstawiono opis przypadku chorej na zaawansowanego raka gruczołowego płuca, z wysoką ekspresją PD-L1 na komórkach nowotworowych, u której wykryto dodatkowo mutację miejsca splicingowego w eksonie 14 genu MET. Pomimo zaawansowania choroby, po przeprowadzeniu stereotaktycznej radioterapii przerzutów do ośrodkowego układu nerwowego chora odniosła spektakularną korzyść z immunoterapii pembrolizumabem początkowo w postaci częściowej remisji, a następnie stabilizacji choroby. Niestety z powodu toksyczności płucnej trzeciego stopnia, która wystąpiła po 3 latach leczenia, terapię przerwano. Pomimo zaprzestania podawania pembrolizumabu przez 9 miesięcy aż do chwili obecnej utrzymuje się stabilizacja choroby nowotworowej, a zmiany zapalne powoli ustąpiły dzięki zastosowaniu steroidoterapii