On the Geometry of the Moduli Space of Real Binary Octics

The moduli space of smooth real binary octics has five connected components. They parametrize the real binary octics whose defining equations have 0, 1, ..., 4 complex-conjugate pairs of roots respectively. We show that the GIT-stable completion of each of these five components admits the structure of an arithmetic real hyperbolic orbifold. The corresponding monodromy groups are, up to commensurability, discrete hyperbolic reflection groups, and their Vinberg diagrams are computed. We conclude with a simple proof that the moduli space of GIT-stable real binary octics itself cannot be a real hyperbolic orbifold.Comment: 23 page

Malignant melanoma of the conjunctiva: a case report with examination of KIT and PDGFRA

Although many clinicopathological studies of malignant melanoma of the conjunctiva have been reported, there have been no studies of the expression and gene mutations of KIT and PDGFRA in melanoma of the conjunctiva. A 69-year-old Japanese woman consulted our hospital because of black mass (0.7 × 0.7 × 0.6 cm) in the conjunctiva. A biopsy was taken. The biopsy showed malignant epithelioid cells with melanin deposition. Immunohistochemically, the tumor was positive for S100 protein, HMB45, p53, Ki-67 (labeling=30%), KIT and PDGFRA. The tumor was negative for pancytokeratins (AE1/3 and CAM5.2). A genetic analysis using PCR-direct sequencing revealed no mutations of KIT gene (exons 9, 11, 13, and 17) and PDGFRA gene (exons 12 and 18). The pathological diagnosis was conjunctival melanoma. Despite chemotherapy, the patient developed multiple metastases of melanoma, and died of melanoma 7 years after the biopsy. In conclusion, the author reported a case of melanoma of conjunctive expressing KIT and PDGFRA proteins without gene mutations of KIT and PDGFRA

Distribution of dust clouds around the central engine of NGC 1068

We studied the distribution of dust clouds around the central engine of NGC 1068 based on shifted-and-added 8.8 - 12.3 micron (MIR) multi-filter images and 3.0 - 3.9 micron (L-band) spectra obtained with the Subaru Telescope. In a region of 100 pc (1.4") around the central peak, we successfully constructed maps of color temperatures and emissivities of the MIR and L-band continua as well as the 9.7 micron and 3.4 micron dust features with spatial resolutions of 26 pc (0.37") in the MIR and 22 pc (0.3") in the L-band. Our main results are: 1) color temperature of the MIR continuum scatters around the thermal equilibrium temperature with the central engine as the heat source while that of the L-band continuum is higher and independent upon distance from the central engine; 2) the peak of the 9.7 micron silicate absorption feature is shifted to a longer wavelength at some locations; 3) the ratio of the optical depths of the dust features is different from the Galactic values and show complicated spatial distribution; and 4) there is a pie shaped warm dust cloud as an enhancement in the emissivity of the MIR continuum extending about 50 pc to the north from the central engine. We speculate that material falls into the central engine through this cloud.Comment: 26 pages, 9 figures. Accepted for publication on Ap

Summary of the 13th IACHEC Meeting

We summarize the outcome of the 13th meeting of the International Astronomical Consortium for High Energy Calibration (IACHEC), held at Tenuta dei Ciclamini (Avigliano Umbro, Italy) in April 2018. Fifty-one scientists directly involved in the calibration of operational and future high-energy missions gathered during 3.5 days to discuss the current status of the X-ray payload inter-calibration and possible approaches to improve it. This summary consists of reports from the various working groups with topics ranging from the identification and characterization of standard calibration sources, multi-observatory cross-calibration campaigns, appropriate and new statistical techniques, calibration of instruments and characterization of background, and communication and preservation of knowledge and results for the benefit of the astronomical community.Comment: 12 page

[OII]3727 Emission from the Companion to the Quasar BR 1202-0725 at z=4.7

Results of a narrow-band imaging for the redshifted [OII]3727 emission around a quasar at z=4.7 obtained with the Subaru telescope and CISCO (a Cassegrain near infrared camera) are presented. A significant emission line is detected in the narrow-band H_2 (v=1-0 S(1)) filter at a location 2.4" northwest from the quasar, where the presence of a companion has been reported in Lyman alpha emission and the rest-frame UV continuum. We identify this line as [OII]3727 emission and confirm that the source really is a companion at z=4.7. The [OII]3727 flux from the companion is estimated to be 2.5 x 10^{-17} erg s^{-1} cm^{-2}. If the companion is a star forming object, the inferred star formation rate is as high as 45-230 M_{solar} yr^{-1} even without assuming the extinction correction. This value is higher than those derived from the Lyman alpha emission or from the UV continuum. Thus, provided that the difference is caused by dust extinction, the extinction corrected star formation rate is calculated to be 45 to 2300 M_{solar} yr^{-1} depending on the assuming extinction curves.Comment: 15 pages including 3 figures. Accepted for publication in PAS

CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung

CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung is very rare. An 82-year-old Japanese woman was found to have an abnormal lung shadow on chest X-ray photography, and was admitted to our hospital. Imaging modalities including X-ray photography, computed tomography, and magnetic resonance imaging showed a small (2 × 1 × 1 cm) opacity of the right upper lobe. Transbronchial lung biopsy was performed. It showed severe proliferation of small lymphocytes. The small lymphocytes were centrocytes-like, and minor plasma cell differentiation was recognized. Lymphoepithelial lesions were scattered. Immunohistochemically, the tumor cells were positive for CD5, CD20, CD43, CD45, CD79α, bcl-2, and κ-chain, but negative for CD2, CD3, CD10, CD21, CD23, CD35, CD45RO, CD56, IgA, IgG, IgM, IgD, λ-chain, TdT, and cyclin D1. The Ki-67 labeling was 10%. CD3-positive and CD45RO-positive inflammatory T-cells were scattered in small amount. The pathological diagnosis was CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung. The patient was treated with chemotherapy (CHOP: cyclophosphamide, hydroxydaunorbicin, vincristine, and predonisone), and the lung tumor disappeared. The patient is now free of the lymphoma 10 years after the first manifestation

H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP. In addition, it has been proposed that AAC mediates mitochondrial uncoupling, but it has proven difficult to demonstrate this function or to elucidate its mechanisms. Here we record AAC currents directly from inner mitochondrial membranes from various mouse tissues and identify two distinct transport modes: ADP/ATP exchange and H+ transport. The AAC-mediated H+ current requires free fatty acids and resembles the H+ leak via the thermogenic uncoupling protein 1 found in brown fat. The ADP/ATP exchange via AAC negatively regulates the H+ leak, but does not completely inhibit it. This suggests that the H+ leak and mitochondrial uncoupling could be dynamically controlled by cellular ATP demand and the rate of ADP/ATP exchange. By mediating two distinct transport modes, ADP/ATP exchange and H+ leak, AAC connects coupled (ATP production) and uncoupled (thermogenesis) energy conversion in mitochondria