6,809 research outputs found
Strain-induced kinetics of intergrain defects as the mechanism of slow dynamics in the nonlinear resonant response of humid sandstone bars
A closed-form description is proposed to explain nonlinear and slow dynamics
effects exhibited by sandstone bars in longitudinal resonance experiments.
Along with the fast subsystem of longitudinal nonlinear displacements we
examine the strain-dependent slow subsystem of broken intergrain and
interlamina cohesive bonds. We show that even the simplest but
phenomenologically correct modelling of their mutual feedback elucidates the
main experimental findings typical for forced longitudinal oscillations of
sandstone bars, namely, (i) hysteretic behavior of a resonance curve on both
its up- and down-slopes, (ii) linear softening of resonant frequency with
increase of driving level, and (iii) gradual recovery (increase) of resonant
frequency at low dynamical strains after the sample was conditioned by high
strains. In order to reproduce the highly nonlinear elastic features of
sandstone grained structure a realistic non-perturbative form of strain
potential energy was adopted. In our theory slow dynamics associated with the
experimentally observed memory of peak strain history is attributed to
strain-induced kinetic changes in concentration of ruptured inter-grain and
inter-lamina cohesive bonds causing a net hysteretic effect on the elastic
Young's modulus. Finally, we explain how enhancement of hysteretic phenomena
originates from an increase in equilibrium concentration of ruptured cohesive
bonds that are due to water saturation.Comment: 5 pages, 3 figure
The fundamental parameters of the roAp star 10 Aql
Due to the strong magnetic field and related abnormal surface layers existing
in rapidly oscillating Ap stars, systematic errors are likely to be present
when determining their effective temperatures, which potentially compromises
asteroseismic studies of these pulsators. Using long-baseline interferometry,
our goal is to determine accurate angular diameters of a number of roAp targets
to provide a temperature calibration for these stars. We obtained
interferometric observations of 10 Aql with the visible spectrograph VEGA at
the CHARA array. We determined a limb-darkened angular diameter of
0.275+/-0.009 mas and deduced a linear radius of 2.32+/-0.09 R_sun. We
estimated the star's bolometric flux and used it, in combination with its
parallax and angular diameter, to determine the star's luminosity and effective
temperature. For two data sets of bolometric flux we derived an effective
temperature of 7800+/-170 K and a luminosity of 18+/-1 L_sun or of 8000+/-210 K
and 19+/-2 L_sun. We used these fundamental parameters together with the large
frequency separation to constrain the mass and the age of 10 Aql, using the
CESAM stellar evolution code. Assuming a solar chemical composition and
ignoring all kinds of diffusion and settling of elements, we obtained a mass of
1.92 M_sun and an age of 780 Gy or a mass of 1.95 M_sun and an age of 740 Gy,
depending on the considered bolometric flux. For the first time, we managed to
determine an accurate angular diameter for a star smaller than 0.3 mas and to
derive its fundamental parameters. In particular, by only combining our
interferometric data and the bolometric flux, we derived an effective
temperature that can be compared to those derived from atmosphere models. Such
fundamental parameters can help for testing the mechanism responsible for the
excitation of the oscillations observed in the magnetic pulsating stars
CHARA/MIRC observations of two M supergiants in Perseus OB1: temperature, Bayesian modeling, and compressed sensing imaging
Two red supergiants of the Per OB1 association, RS Per and T Per, have been
observed in H band using the MIRC instrument at the CHARA array. The data show
clear evidence of departure from circular symmetry. We present here new
techniques specially developed to analyze such cases, based on state-of-the-art
statistical frameworks. The stellar surfaces are first modeled as limb-darkened
discs based on SATLAS models that fit both MIRC interferometric data and
publicly available spectrophotometric data. Bayesian model selection is then
used to determine the most probable number of spots. The effective surface
temperatures are also determined and give further support to the recently
derived hotter temperature scales of red su- pergiants. The stellar surfaces
are reconstructed by our model-independent imaging code SQUEEZE, making use of
its novel regularizer based on Compressed Sensing theory. We find excellent
agreement between the model-selection results and the reconstructions. Our
results provide evidence for the presence of near-infrared spots representing
about 3-5% of the stellar flux
Radial Structure in the TW Hya Circumstellar Disk
We present new near-infrared interferometric data from the CHARA array and the Keck Interferometer on the circumstellar disk of the young star, TW Hya, a proposed "transition disk." We use these data, as well as previously published, spatially resolved data at 10 μm and 7 mm, to constrain disk models based on a standard flared disk structure. We find that we can match the interferometry data sets and the overall spectral energy distribution with a three-component model, which combines elements at spatial scales proposed by previous studies: optically thin, emission nearest the star, an inner optically thick ring of emission at roughly 0.5 AU followed by an opacity gap and, finally, an outer optically thick disk starting at ~4 AU. The model demonstrates that the constraints imposed by the spatially resolved data can be met with a physically plausible disk but this requires a disk containing not only an inner gap in the optically thick disk as previously suggested, but also a gap between the inner and outer optically thick disks. Our model is consistent with the suggestion by Calvet et al. of a planet with an orbital radius of a few AU. We discuss the implications of an opacity gap within the optically thick disk
Biomarker Discovery In Chronic Obstructive Pulmonary Disease (COPD) Using Epithelial Lining Fluid:A Proteomic Approach
RATIONALE Chronic Obstructive Pulmonary Disease (COPD) is the third most frequent disease worldwide with increasing mortality. Cigarette smoking is the principle risk factor and 15-20% of smokers develop COPD. Epithelial Lining Fluid (ELF) covers the internal part of the airways and can be collected during bronchoscopy. ELF appears to be well-suited for proteomic analysis, since it contains a higher concentration of proteins (150-300 μg /mL) than other lung fluids and can be obtained from different locations of the lungs. No comprehensive proteomic analysis of human ELF has been performed to date, which makes ELF a highly interesting fluid for biomarker discovery in COPD. AIM To discover proteins that change in abundance in ELF from COPD patients versus healthy controls using a quantitative proteomics approach. METHODS The ELF proteome from COPD patients and healthy controls was studied by 1D polyacrylamide gel electrophoresis in the presence of SDS followed by in-gel tryptic digestion to establish the methodology and assess the feasibility of such an approach. Approximately 40 gel slices were obtained from each lane of the gel (corresponding to one patient). Digested samples were analyzed by nanoChip-LC-MS/MS using an ion trap. We performed a quantitative pilot study of ELF from 4 COPD patients and 4 healthy controls (table 1) to test for statistically significant differences in protein levels. ELF samples were digested by trypsin, labeled with stable isotope-containing reagents (iTRAQ®, 8-plex) and processed by strong cation-exchange chromatography followed by nanoLC-MS/MS. In order to validate the results, a second quantitative analysis of an independent sample set (4 COPD vs 4 healthy) using the same methodological approach was done. RESULTS The 1D electrophoretic approach resulted in more than 300 identified proteins. Most of the identified proteins were present in both COPD and healthy samples, although some proteins were only identified either in healthy control or in COPD samples. The quantitative studies showed that a number of proteins was significantly different between ELF of COPD patients and controls, including 4 up-regulated proteins in common in both studies. CONCLUSIONS This is the first study in ELF of COPD patients and healthy controls in which such a large number of proteins has been identified. The obtained results show the feasibility of this proteomic approach and the possibility to discover proteins that are differentially expressed in ELF of COPD patients and controls. We are currently validating these proteins further by western blot and immunohistochemistry
Biomarker Discovery In Chronic Obstructive Pulmonary Disease (COPD) Using Epithelial Lining Fluid:A Proteomic Approach
Simplicity transformations for three-way arrays with symmetric slices, and applications to Tucker-3 models with sparse core arrays
AbstractTucker three-way PCA and Candecomp/Parafac are two well-known methods of generalizing principal component analysis to three way data. Candecomp/Parafac yields component matrices A (e.g., for subjects or objects), B (e.g., for variables) and C (e.g., for occasions) that are typically unique up to jointly permuting and rescaling columns. Tucker-3 analysis, on the other hand, has full transformational freedom. That is, the fit does not change when A,B, and C are postmultiplied by nonsingular transformation matrices, provided that the inverse transformations are applied to the so-called core array G̲. This freedom of transformation can be used to create a simple structure in A,B,C, and/or in G̲. This paper deals with the latter possibility exclusively. It revolves around the question of how a core array, or, in fact, any three-way array can be transformed to have a maximum number of zero elements. Direct applications are in Tucker-3 analysis, where simplicity of the core may facilitate the interpretation of a Tucker-3 solution, and in constrained Tucker-3 analysis, where hypotheses involving sparse cores are taken into account. In the latter cases, it is important to know what degree of sparseness can be attained as a tautology, by using the transformational freedom. In addition, simplicity transformations have proven useful as a mathematical tool to examine rank and generic or typical rank of three-way arrays. So far, a number of simplicity results have been attained, pertaining to arrays sampled randomly from continuous distributions. These results do not apply to three-way arrays with symmetric slices in one direction. The present paper offers a number of simplicity results for arrays with symmetric slices of order 2×2,3×3 and 4×4. Some generalizations to higher orders are also discussed. As a mathematical application, the problem of determining the typical rank of 4×3×3 and 5×3×3 arrays with symmetric slices will be revisited, using a sparse form with only 8 out of 36 elements nonzero for the former case and 10 out of 45 elements nonzero for the latter one, that can be attained almost surely for such arrays. The issue of maximal simplicity of the targets to be presented will be addressed, either by formal proofs or by relying on simulation results
Biomarker Discovery In Chronic Obstructive Pulmonary Disease (COPD) Using Epithelial Lining Fluid:A Proteomic Approach
Regular Conjugacy Classes in the Weyl Group and Integrable Hierarchies
Generalized KdV hierarchies associated by Drinfeld-Sokolov reduction to grade
one regular semisimple elements from non-equivalent Heisenberg subalgebras of a
loop algebra \G\otimes{\bf C}[\lambda,\lambda^{-1}] are studied. The graded
Heisenberg subalgebras containing such elements are labelled by the regular
conjugacy classes in the Weyl group {\bf W}(\G) of the simple Lie algebra
\G. A representative w\in {\bf W}(\G) of a regular conjugacy class can be
lifted to an inner automorphism of \G given by , where is the defining vector of an subalgebra
of \G.The grading is then defined by the operator and any grade one regular element from the
Heisenberg subalgebra associated to takes the form , where and is included in an
subalgebra containing . The largest eigenvalue of is
except for some cases in , . We explain how these Lie
algebraic results follow from known results and apply them to construct
integrable systems.If the largest eigenvalue is , then
using any grade one regular element from the Heisenberg subalgebra associated
to we can construct a KdV system possessing the standard \W-algebra
defined by as its second Poisson bracket algebra. For \G a classical
Lie algebra, we derive pseudo-differential Lax operators for those
non-principal KdV systems that can be obtained as discrete reductions of KdV
systems related to . Non-abelian Toda systems are also considered.Comment: 44 pages, ENSLAPP-L-493/94, substantial revision, SWAT-95-77. (use
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