A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence

Non-Alcoholic Fatty Liver Disease (NAFLD) is now the most prevalent form of chronic liver disease, affecting 10%–20% of the general paediatric population. Within the next 10 years it is expected to become the leading cause of liver pathology, liver failure and indication for liver transplantation in childhood and adolescence in the Western world. While our understanding of the pathophysiological mechanisms underlying this disease remains limited, it is thought to be the hepatic manifestation of more widespread metabolic dysfunction and is strongly associated with a number of metabolic risk factors, including insulin resistance, dyslipidaemia, cardiovascular disease and, most significantly, obesity. Despite this, ”paediatric” NAFLD remains under-studied, under-recognised and, potentially, undermanaged. This article will explore and evaluate our current understanding of NAFLD in childhood and adolescence and how it differs from adult NAFLD, in terms of its epidemiology, pathophysiology, natural history, diagnosis and clinical management. Given the current absence of definitive radiological and histopathological diagnostic tests, maintenance of a high clinical suspicion by all members of the multidisciplinary team in primary and specialist care settings remains the most potent of diagnostic tools, enabling early diagnosis and appropriate therapeutic intervention

Release of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX) from polymer-bonded explosives (PBXN 109) into water by artificial weathering

Polymer-bonded explosives (PBX) fulfil the need for insensitive munitions. However, the environmental impacts of PBX are unclear, even though it is likely that PBX residues from low-order detonations and unexploded ordnance are deposited on military training ranges. The release of high explosives from the polymer matrix into the environment has not been studied in detail, although as polymers degrade slowly in the environment we anticipate high explosives to be released into the environment. In this study, PBXN-109 (nominally 64% RDX) samples were exposed to variable UK climatic conditions reproduced in the laboratory to determine the effects of temperature, UV irradiation and rainfall on the release of RDX from the polymer binder. The most extreme conditions for spring, summer and winter in the UK were artificially reproduced. We found that up to 0.03% of RDX was consistently released from PBXN-109. The rate of RDX release was highest in samples exposed to the summer simulation, which had the lowest rainfall, but the highest temperatures and longest UV exposure. This was confirmed by additional experiments simulating an extreme summer month with consistently high temperatures and long periods of sunlight. These results probably reflect the combination of polymer swelling and degradation when samples are exposed to higher temperatures and prolonged UV irradiation

Lesbian, Gay, Bisexual, and Transgender (LGBT) Issues in Dental School Environments: Dental Student Leaders’ Perceptions

The objectives of the study reported in this article were to assess dental student leaders’ perceptions of educational efforts concerning lesbian, gay, bisexual, and transgender (LGBT) topics and the cultural climate concerning LGBT issues in dental schools in the United States and Canada. In addition, the perceptions of student leaders who self‐identified as belonging to the LGBT community and of students with a heterosexual orientation were compared. Data were collected from 113 dental student leaders from twenty‐seven dental schools in the United States and three in Canada. Fifty student leaders were females, and sixty‐two were males. Only 13.3 percent of the respondents agreed that their dental education prepared them well to treat patients from LGBT backgrounds. The more the student leaders believed that their university has an honest interest in diversity, the better they felt prepared by their dental school program to treat patients from LGBT backgrounds (r=.327; p<.001). The better they felt prepared, the more they perceived the clinic environment as sensitive and affirming for patients with different sexual orientations (r=.464; p<.001). The more they reported that dental schools’ administrations create a positive environment for students with LGBT orientations, the more they agreed that persons can feel comfortable regardless of their sexual orientation (r=.585; p<.001). In conclusion, the findings indicate that dental school administrators play an important role in ensuring that future care providers are well prepared to treat patients from LGBT backgrounds and that staff, faculty, students, and patients from these backgrounds are not discriminated against.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153661/1/jddj002203372009731tb04643x.pd

Improving bycatch mitigation measures for marine megafauna in Zanzibar, Tanzania

This study was conducted to explore the governance processes and socio-economic factors relevant to the potential implementation of bycatch mitigation for various vulnerable marine megafauna (rays, sharks, marine mammals and turtles) in Zanzibar, Tanzania. Questionnaire-based interviews were conducted between February and April 2017 with fishers (n= 240) at eight landing sites. One focus group discussion was held in each site and eleven key informant interviews were carried out. The study showed that current measures to manage bycatch rates are not explicit; no rules govern rays and sharks bycatch; and rules regarding marine mammal and sea turtle bycatch are poorly enforced. Binary logistic regression was used to determine the effect of five selected socio-economic factors (education, age, proportional fishing income, fishing experience, and the number of adults who bring income into the household) on the willingness of fishers to participate in potential future bycatch mitigation measures for marine megafauna. The results indicate that only one factor (the number of adults who bring income into the household) had any significant effect (p=0.016). These findings could benefit the future governance and management of marine megafauna in Zanzibar through a better understanding of what mitigation measures are more likely to be supported

Biochemical status of vitamin A in colorectal cancer

Serum vitamin A and its carrier proteins, retinol-binding protein and prealbumin, were measured in 41 colorectal cancer patients, 40 patients with benign colorectal disease, and 31 healthy subjects. Serum samples were obtained from the Mayo Clinic (NCI-Serum diagnostic Bank, Rochester, MN), The values for each of the three parameters were significantly lower in colorectal cancer patients than in healthy subjects but were litte1e different from the val ues seen in patients with benign disease

Ground State Energy of the Low Density Bose Gas

Now that the properties of low temperature Bose gases at low density, $\rho$, can be examined experimentally it is appropriate to revisit some of the formulas deduced by many authors 4-5 decades ago. One of these is that the leading term in the energy/particle is $2\pi \hbar^2 \rho a/m$, where $a$ is the scattering length. Owing to the delicate and peculiar nature of bosonic correlations, four decades of research have failed to establish this plausible formula rigorously. The only known lower bound for the energy was found by Dyson in 1957, but it was 14 times too small. The correct bound is proved here.Comment: 4 pages, Revtex, reference 12 change

Siren songs or path to salvation? Interpreting the visions of web technology at a UK regional newspaper in crisis, 2006-11

A 5-year case study of an established regional newspaper in Britain investigates journalists about their perceptions of convergence in digital technologies. This research is the first ethnographic longitudinal case study of a UK regional newspaper. Although conforming to some trends observed in the wider field of scholarship, the analysis adds to skepticism about any linear or directional views of innovation and adoption: the Northern Echo newspaper journalists were observed to have revised their opinions of optimum Web practices, and sometimes radically reversed policies. Technology is seen in the period as a fluid, amorphous entity. Central corporate authority appeared to diminish in the period as part of a wider reduction in formalism. Questioning functionalist notions of the market, the study suggests cause and effect models of change are often subverted by contradictory perceptions of particular actions. Meanwhile, during technological evolution, the ‘professional imagination’ can be understood as strongly reflecting the parent print culture and its routines, despite pioneering a new convergence partnership with an independent television company

Industrial work placement in higher education: a study of civil engineering student engagement

For civil engineering undergraduates, the opportunity to spend a period of time in formal industrial work placement provides an invaluable learning experience. This paper reviews student engagement with short-term industrial placement and provides analysis of questionnaires (n=174) returned by undergraduates studying civil engineering at four Higher Education Institutes (HEI’s) in the West of Scotland. The data captures industrial placement statistics, employability skill-sets and presents brief testimonies from students. Whilst the journey to becoming a professional civil engineer is undoubtedly enhanced by short-term placement clear opportunities exist for HEI’s to affect and change existing pedagogical discourse. Commentary is likely to resonate beyond civil engineering and serve as a timely reminder of the need to re-invigorate academia / industry curriculum partnerships

Marine megafauna catch in southwestern Indian Ocean small-scale fisheries from landings data

The measurable impacts of small-scale fisheries on coastal marine ecosystems and vulnerable megafauna species (elasmobranchs, marine mammals and sea turtles) within them are largely unknown, particularly in developing countries. This study assesses megafauna catch and composition in handline, longline, bottom-set and drift gillnet fisheries of the southwestern Indian Ocean. Observers monitored 21 landing sites across Kenya, Zanzibar and northern Madagascar for 12 months in 2016–17. Landings (n = 4666) identified 59 species, including three sea turtles, two small cetaceans and one sirenian (Dugong dugon). Primary gear threats to investigated taxa were identified as bottom-set gillnets (marine mammals, sea turtles and batoids), drift gillnets (marine mammals, batoids and sharks) and longlines (sharks). Overall, catch was dominated by small and moderately sized coastal requiem sharks (Carcharhiniformes) and whiprays (Dasyatidae). Larger coastal and oceanic elasmobranchs were also recorded in substantial numbers as were a number of deeper-water species. The diversity of catch demonstrates the potential for small-scale fisheries to have impacts across a number of ecosystems. From the observed catch rates we calculated annual regional elasmobranch landings to be 35,445 (95%CI 30,478–40,412) tonnes, 72.6% more than officially reported in 2016 and 129.2% more than the 10-year average (2006–16), constituting 2.48 (95%CI 2.20–2.66) million individuals. Productivity-Susceptibility Analyses indicate that small and moderately sized elasmobranchs are most vulnerable in the small-scale fisheries. The study demonstrates substantial underreporting of catches in small-scale fisheries and highlights the need to expand efforts globally to assess the extent and impact of small-scale fisheries on vulnerable marine species and their respective ecosystems

Coexistence of glassy antiferromagnetism and giant magnetoresistance (GMR) in Fe/Cr multilayer structures

Using temperature-dependent magnetoresistance and magnetization measurements on Fe/Cr multilayers that exhibit pronounced giant magnetoresistance (GMR), we have found evidence for the presence of a glassy antiferromagnetic (GAF) phase. This phase reflects the influence of interlayer exchange coupling (IEC) at low temperature (T < 140K) and is characterized by a field-independent glassy transition temperature, Tg, together with irreversible behavior having logarithmic time dependence below a "de Almeida and Thouless" (AT) critical field line. At room temperature, where the GMR effect is still robust, IEC plays only a minor role, and it is the random potential variations acting on the magnetic domains that are responsible for the antiparallel interlayer domain alignment.Comment: 5 pages, 4 figure