Liver-Metabolizing Genes and Their Relationship to the Performance of Elite Spanish Male Endurance Athletes; a Prospective Transversal Study.

Background: The genetic profile that is needed to define an endurance athlete has been studied during recent years. The main objective of this work is to approach for the first time the study of genetic variants in livermetabolizing genes and their role in endurance performance by comparing the allelic and genotypic frequencies in elite endurance athletes to the non-athlete population. Methods: Genotypic and allelic frequencies were determined in 123 elite endurance athletes (75 professional road cyclists and 48 endurance elite runners) and 122 male non-athlete subjects (sedentary). Genotyping of cytochrome P450 family 2 subfamily D member 6 (CYP2D6 rs3892097), glutathione-S transferase mu isoform 1 (GSTM1), glutathione S-transferase pi (GSTP rs1695) and glutathione S-transferase theta (GSTT) genes was performed by polymerase chain reaction (PCR). The combination of the polymorphisms for the “optimal” polygenic profile has been quantified using the genotype score (GS). Results: Statistical differences were found in the genetic distributions between elite endurance athletes and nonathletes in CYP2D6 (p < 0.001) and GSTT (p = 0.014) genes. The binary logistic regression model showed a favourable OR (odds ratio) of being an elite endurance runner against a professional road cyclist (OR: 2.403, 95% CI:1.213–4.760 (p = 0.002)) in the polymorphisms studied. Conclusions: Genotypic distribution of liver-metabolizing genes in elite endurance athletes is different to nonathlete subjects, with a favourable gene profile in elite endurance athletes in terms of detoxification capacity.post-print814 K

Modelos predictivos para el análisis de la mortalidad intrahospitalaria por COVID19 en Aragón con validación entre olas epidémicas.

Este trabajo de fin de máster está dedicado a realizar un proyecto para predecir la mortalidad intrahospitalaria en Aragón debido al COVID-19. Se utilizan técnicas de aprendizaje automático, entrenando a los modelos con datos de la primera ola epidémica, con el fin de predecir la mortalidad intrahospitalaria en el resto de olas epidémicas. Se trabaja con un conjunto amplio de variables relacionadas con la bioquímica y la hematología. El modelo no pretende limitarse a la epidemia de COVID-19, sino que puede utilizarse como marco general para otras epidemias futuras.<br /

Changes in severity, mortality, and virus genome among a Spanish cohort of patients hospitalized with SARS-CoV-2

Comparing pandemic waves could aid in understanding the evolution of COVID-19. The objective of the present study was to compare the characteristics and outcomes of patients hospitalized for COVID-19 in different pandemic waves in terms of severity and mortality. We performed an observational retrospective cohort study of 5,220 patients hospitalized with SARS-CoV-2 infection from February to September 2020 in Aragon, Spain. We compared ICU admissions and 30-day mortality, clinical characteristics, and risk factors of the first and second waves of COVID-19. The SARS-CoV-2 genome was also analyzed in 236 samples. Patients in the first wave (n¿=¿2,547) were older (median age 74 years [IQR 60–86] vs. 70 years [53–85]; p¿&lt;¿0.001) and had worse clinical and analytical parameters related to severe COVID-19 than patients in the second wave (n¿=¿2,673). The probability of ICU admission at 30 days was 16% and 10% (p¿&lt;¿0.001) and the cumulative 30-day mortality rates 38% and 32% in the first and second wave, respectively (p¿=¿0.007). Survival differences were observed among patients aged 60 to 80 years. We also found some variability among death risk factors and the viral genome between waves. Therefore, the two analyzed COVID-19 pandemic waves were different in terms of disease severity and mortality

Estudio experimental: nuevos enfoques de terapia ocupacional en el deporte

Objective: The aim is to analyze if the players of a soccer team increase their cognitive abilities and sports performancethrough cognitive training from Occupational Therapy. Methods: Non-randomized experimental study that follows the pertinent ethical considerations was carried out on sixteen 14-15 year-old players from a soccer team, by collecting data through 4 ad hoc and 1 standardized scales. 30 sessions are held with a weekly duration of 30 min. Results: We extract an improvement in the cognitive aspects worked on, highlighting the results obtained in Trail Making Test, with a 22% improvement in part A and 26% in part B (P-value <0.01) and in the ad hoc Semiotic Space scale with an overall improvement of 76%. Conclusions: Occupational Therapy could contribute with its knowledge and tools in the sports field to work on cognitive and group cohesion aspects, impacting on the performance and occupational identity of the players.Objetivos: analizar si los jugadores de un equipo de fútbol a través de un entrenamiento cognitivo desde Terapia Ocupacional incrementan sus habilidades cognitivas y rendimiento deportivo. Métodos: estudio experimental no aleatorio que sigue las consideraciones éticas pertinentes, realizado a 16 jugadores de 14-15 años de un equipo de fútbol, mediante la recogida de datos a través de 4 escalas ad hoc y 1 estandarizada. Se realizan 30 sesiones con periodicidad semanal de 30 min de duración. Resultados: extraemos una mejora de los aspectos cognitivos trabajados, destacando los resultados obtenidos en la prueba TrailMaking Test, con un 22% de mejora en la parte A y un 26% en la parte B (P-value<0.01) y la escala ad hoc de Espacio Semiótico con una mejora global del 76%. Conclusiones: la Terapia Ocupacional podría aportar sus conocimientos y herramientas en el ámbito deportivo para trabajar aspectos cognitivos y de cohesión grupal, repercutiendo en el desempeño e identidad ocupacional de los jugadores