Dynamic plantar loading index detects altered foot function in individuals with rheumatoid arthritis but not changes due to orthotic use

Background Altered foot function is common in individuals with rheumatoid arthritis. Plantar pressure distributions during gait are regularly assessed in this patient group; however, the association between frequently reported magnitude-based pressure variables and clinical outcomes has not been clearly established. Recently, a novel approach to the analysis of plantar pressure distributions throughout stance phase, the dynamic plantar loading index, has been proposed. This study aimed to assess the utility of this index for measuring foot function in individuals with rheumatoid arthritis.Methods Barefoot plantar pressures during gait were measured in 63 patients with rheumatoid arthritis and 51 matched controls. Additionally, 15 individuals with rheumatoid arthritis had in-shoe plantar pressures measured whilst walking in standardized footwear for two conditions: shoes-only; and shoes with prescribed custom foot orthoses. The dynamic plantar loading index was determined for all participants and conditions. Patient and control groups were compared for significant differences as were the shod and orthosis conditions.Findings The patient group was found to have a mean index of 0.19, significantly lower than the control group's index of 0.32 (p > 0.001, 95% CI [0.054, 0.197]). No significant differences were found between the shoe-only and shoe plus orthosis conditions. The loading index was found to correlate with clinical measures of structural deformity.Interpretation The dynamic plantar loading index may be a useful tool for researchers and clinicians looking to objectively assess dynamic foot function in patients with rheumatoid arthritis; however, it may be unresponsive to changes caused by orthotic interventions in this patient group.</p

Embracing additive manufacture: implications for foot and ankle orthosis design

<p>Abstract</p> <p>Background</p> <p>The design of foot and ankle orthoses is currently limited by the methods used to fabricate the devices, particularly in terms of geometric freedom and potential to include innovative new features. Additive manufacturing (AM) technologies, where objects are constructed via a series of sub-millimetre layers of a substrate material, may present the opportunity to overcome these limitations and allow novel devices to be produced that are highly personalised for the individual, both in terms of fit and functionality.</p> <p>Two novel devices, a foot orthosis (FO) designed to include adjustable elements to relieve pressure at the metatarsal heads, and an ankle foot orthosis (AFO) designed to have adjustable stiffness levels in the sagittal plane, were developed and fabricated using AM. The devices were then tested on a healthy participant to determine if the intended biomechanical modes of action were achieved.</p> <p>Results</p> <p>The adjustable, pressure relieving FO was found to be able to significantly reduce pressure under the targeted metatarsal heads. The AFO was shown to have distinct effects on ankle kinematics which could be varied by adjusting the stiffness level of the device.</p> <p>Conclusions</p> <p>The results presented here demonstrate the potential design freedom made available by AM, and suggest that it may allow novel personalised orthotic devices to be produced which are beyond the current state of the art.</p

Egg Formation in Lepidoptera

Reproductive biology in the Twentieth Century produced comprehensive descriptions of the mechanisms of egg formation in most of the major orders of insects. While many general principles of ovarian development and physiology emerged, every order turned out to have a set of its own special motifs. Discovery of the lepidopteran motifs is summarized in this essay. The emphasis is on developmental mechanisms, beginning with the early growth and differentiation of female germ cells and ending, after many turns in morphogenesis, physiology and biosynthesis, with eggs that are filled with yolk and encased in chorions. Examples of uniquely lepidopteran traits include the cellular composition of ovarian follicles, the number of tubular ovarioles in which they mature, the functions of cell-to-cell junctional complexes in their maturation, their use of glycosaminoglycans to maintain intercellular patency during vitellogenesis, the role of proton and calcium pumps in their ion physiology, a separate postvitellogenic period of water and inorganic ion uptake, and the fine structure and protein composition of their chorions. Discovery of this combination of idiosyncracies was based on advances in the general concepts and techniques of cell and molecular biology and on insights borrowed from studies on other insects. The lepidopteran ovary in turn has contributed much to the understanding of egg formation in insects generally

Active Galaxies in the UV

In this article we present different aspects of AGN studies demonstrating the importance of the UV spectral range. Most important diagnostic lines for studying the general physical conditions as well as the metalicities in the central broad line region in AGN are emitted in the UV. The UV/FUV continuum in AGN excites not only the emission lines in the immediate surrounding but it is responsible for the ionization of the intergalactic medium in the early stages of the universe. Variability studies of the emission line profiles of AGN in the UV give us information on the structure and kinematics of the immediate surrounding of the central supermassive black hole as well as on its mass itself.Comment: 29 pages, 13 figures, Ap&SS in pres

Background Assay and Rejection in DRIFT

The DRIFT-IId dark matter detector is a m3-scale low-pressure TPC with directional sensitivity to WIMP-induced nuclear recoils. Its primary backgrounds were due to alpha decays from contamination on the central cathode. Efforts to reduce these backgrounds led to replacing the 20 μm wire central cathode with one constructed from 0.9 μm aluminized mylar, which is almost totally transparent to alpha particles. Detailed modeling of the nature and origin of the remaining backgrounds led to an in-situ, ppt-sensitive assay of alpha decay backgrounds from the central cathode. This led to further improvements in the thin-film cathode resulting in over 2 orders of magnitude reduction in backgrounds compared to the wire cathode. Finally, the addition of O2 to CS2 gas was found to produce multiple species of electronegative charge carriers, providing a method to determine the absolute position of nuclear recoils and reject all known remaining backgrounds while retaining a high efficiency for nuclear recoil detection

A Runaway Black Hole in COSMOS: Gravitational Wave or Slingshot Recoil?

We present a detailed study of a peculiar source in the COSMOS survey at z=0.359. Source CXOCJ100043.1+020637 (CID-42) presents two compact optical sources embedded in the same galaxy. The distance between the 2, measured in the HST/ACS image, is 0.495" that, at the redshift of the source, corresponds to a projected separation of 2.46 kpc. A large (~1200 km/s) velocity offset between the narrow and broad components of Hbeta has been measured in three different optical spectra from the VLT/VIMOS and Magellan/IMACS instruments. CID-42 is also the only X-ray source having in its X-ray spectra a strong redshifted broad absorption iron line, and an iron emission line, drawing an inverted P-Cygni profile. The Chandra and XMM data show that the absorption line is variable in energy by 500 eV over 4 years and that the absorber has to be highly ionized, in order not to leave a signature in the soft X-ray spectrum. That these features occur in the same source is unlikely to be a coincidence. We envisage two possible explanations: (1) a gravitational wave recoiling black hole (BH), caught 1-10 Myr after merging, (2) a Type 1/ Type 2 system in the same galaxy where the Type 1 is recoiling due to slingshot effect produced by a triple BH system. The first possibility gives us a candidate gravitational waves recoiling BH with both spectroscopic and imaging signatures. In the second case, the X-ray absorption line can be explained as a BAL-like outflow from the foreground nucleus (a Type 2 AGN) at the rearer one (a Type 1 AGN), which illuminates the otherwise undetectable wind, giving us the first opportunity to show that fast winds are present in obscured AGN.Comment: 13 figures; submitted to ApJ. Sent back to the referee after the first interaction and awaiting the final comment

Long-term study of backgrounds in the DRIFT-II directional dark matter experiment

Low-pressure gas Time Projection Chambers being developed for directional dark matter searches offer a technology with strong particle identification capability combined with the potential to produce a definitive detection of Galactic Weakly Interacting Massive Particle (WIMP) dark matter. A source of events able to mimic genuine WIMP-induced nuclear recoil tracks arises in such experiments from the decay of radon gas inside the vacuum vessel. The recoils that result from associated daughter nuclei are termed Radon Progeny Recoils (RPRs). We present here experimental data from a long-term study using the DRIFT-II directional dark matter experiment at the Boulby Underground Laboratory of the RPRs, and other backgrounds that are revealed by relaxing the normal cuts that are applied to WIMP search data. By detailed examination of event classes in both spatial and time coordinates using 3.5 years of data, we demonstrate the ability to determine the origin of 4 specific background populations and describe development of new technology and mitigation strategies to suppress them