VLT spectropolarimetry of two powerful radio galaxies at z~1.4: UV continuum, emission-line properties and the nature of high-redshift dust

(Abridged) Deep VLT spectropolarimetric observations are presented for two powerful radio galaxies, 0850-206 and 1303+091. These observations cover the rest-frame wavelength range ~ 1450 - 3750 A. New radio observations and continuum images of the same sources are also presented. These galaxies are the first two observed from a complete sample of nine radio sources with redshifts in the range 1.3 < z < 1.5 (selected from the equatorial sample of powerful radio sources of Best, Rottgering & Lehnert), as part of a project aimed to investigate the multi-component nature of the UV continuum in radio galaxies and any variations of the continuum properties with the radio source age. The larger radio source of the two, 0850-206, presents a high continuum fractional polarization, averaging 17% across the observed wavelength range and reaching 24% at rest-frame wavelengths of <2000 A. The smaller radio source, 1303+091, shows a lower continuum polarization, averaging 8% and rising to 11% for rest-frame wavelengths >3000 A. For both galaxies, the position angle of the electric vector is generally constant with wavelength and within ~15 degrees of perpendicular to the radio axis. Both their total flux spectra and polarized flux spectra reveal the 2200 A dust feature, and comparison with dust scattering models suggests that the composition of the dust in these galaxies is similar to that of Galactic dust. In 0850-206, scattered quasar radiation dominates the UV continuum emission, with the nebular continuum accounting for no more than ~22% and no requirement for any additional emission component such as emission from young stars. By contrast, in 1303+091, unpolarized radiation could be a major constituent of the UV continuum emission, with starlight accounting for up to ~50% and the nebular continuum accounting for ~11%.Comment: 20 pages, including 14 figures. MNRAS accepte

17β-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response

The putative oestrogen receptor negative human breast cancer cell line MDA231, when grown as tumours in mice continually receiving 17β-oestradiol, showed substantially increased growth rate when compared to control animals. Further, we observed that 17β-oestradiol treatment could both increase the growth rate of established MDA231 tumours as well as decreasing the time taken for initiating tumour growth. We have also demonstrated that this increase in growth rate is accompanied by a four-fold increase in nitric oxide synthase activity, which was predominantly the inducible form. Inducible-nitric oxide synthase expression in these tumours was confirmed by immunohistochemical analysis and appeared localized primarily in areas between viable and necrotic regions of the tumour (an area that is presumably hypoxic). Prophylactic treatment with the nitric oxide synthase inhibitor nitro-L-arginine methyl ester resulted in significant reduction in this apparent 17β-oestradiol-mediated growth promoting effect. Tumours derived from mice receiving 17β-oestradiol-treatment were characterized by a significantly lower fraction of perfused blood vessels and an indication of an increased hypoxic fraction. Consistent with these observations, 17β-oestradiol-treated tumours were less radio-responsive compared to control tumours when treated with a single radiation dose of 15 Gy. Our data suggests that long-term treatment with oestrogen could significantly alter the tumour oxygenation status during breast tumour progression, thus affecting response to radiotherapy

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Biodiversity inventories in high gear: DNA barcoding facilitates a rapid biotic survey of a temperate nature reserve

Comprehensive biotic surveys, or ‘all taxon biodiversity inventories’ (ATBI), have traditionally been limited in scale or scope due to the complications surrounding specimen sorting and species identification. To circumvent these issues, several ATBI projects have successfully integrated DNA barcoding into their identification procedures and witnessed acceleration in their surveys and subsequent increase in project scope and scale. The Biodiversity Institute of Ontario partnered with the rare Charitable Research Reserve and delegates of the 6th International Barcode of Life Conference to complete its own rapid, barcode-assisted ATBI of an established land trust in Cambridge, Ontario, Canada

Environments, Goals And Technology: An Analysis Of Organizational Changein A New Juvenile Correctional Institution.

PhDCriminologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/190993/2/7324550.pd