Type I interferons in tuberculosis: Foe and occasionally friend

Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection. Type I interferons (IFN) regulate a broad family of genes that either stimulate or inhibit immune function, having both host-protective and detrimental effects, and exhibit well-characterized antiviral activity. Transcriptional studies have uncovered a potential deleterious role for type I IFN in active tuberculosis. Since then, additional studies in human tuberculosis and experimental mouse models of M. tuberculosis infection support the concept that type I IFN promotes both bacterial expansion and disease pathogenesis. More recently, studies in a different setting have suggested a putative protective role for type I IFN. In this study, we discuss the mechanistic and contextual factors that determine the detrimental versus beneficial outcomes of type I IFN induction during M. tuberculosis infection, from human disease to experimental mouse models of tuberculosis

Performance of dynamical decoupling in bosonic environments and under pulse-timing fluctuations

We study the suppression of qubit dephasing through Uhrig dynamical decoupling (UDD) in nontrivial environments modeled within the spin-boson formalism. In particular, we address the case of (i) a qubit coupled to a bosonic bath with power-law spectral density, and (ii) a qubit coupled to a single harmonic oscillator that dissipates energy into a bosonic bath, which embodies an example of a structured bath for the qubit. We then model the influence of random time jitter in the UDD protocol by sorting pulse-application times from Gaussian distributions centered at appropriate values dictated by the optimal protocol. In case (i) we find that, when few pulses are applied and a sharp cutoff is considered, longer coherence times and robust UDD performances (against random timing errors) are achieved for a super-Ohmic bath. On the other hand, when an exponential cutoff is considered a super-Ohmic bath is undesirable. In case (ii) the best scenario is obtained for an overdamped harmonic motion. Our study provides relevant information for the implementation of optimized schemes for the protection of quantum states from decoherence.Comment: 8 pages, 5 figure

Contract Innovation in Germany: An Economic Evaluation of Pacts for Employment and Competitiveness

Pacts for employment and competitiveness are an integral component of the ongoing process of decentralization of collective bargaining in Germany, a phenomenon that has been hailed as key to that nation's economic resurgence. Yet little is known about the effects of pacts on firm performance. The evidence largely pertains to employment and is decidedly mixed. This article investigates the association between pacts and six outcome indicators using a framework in which the controls comprise establishments that negotiated over pacts but failed to reach agreement on their implementation. An extensive set of robustness checks are run to test the sensitivity of the key findings of the model. There is no suggestion of pacts negatively impacting any of the selected measures of establishment performance. Rather, the evidence points to some positive short- and medium-run effects on firm average wages and possibly employment and innovation as well

Transient analysis of spectrally asymmetric magnetic photonic crystals with ferromagnetic losses

We analyze transient electromagnetic pulse propagation in spectrally asymmetric magnetic photonic crystals (MPCs) with ferromagnetic losses. MPCs are dispersion-engineered materials consisting of a periodic arrangement of misaligned anisotropic dielectric and ferromagnetic layers that exhibit a stationary inflection point in the (asymmetric) dispersion diagram and unidirectional frozen modes. The analysis is performed via a late-time stable finite-difference time-domain method (FDTD) implemented with perfectly matched layer (PML) absorbing boundary conditions, and extended to handle (simultaneously) dispersive and anisotropic media. The proposed PML-FDTD algorithm is based on a D-H and B-E combined field approach that naturally decouples the FDTD update into two steps, one involving the (anisotropic and dispersive) constitutive material tensors and the other involving Maxwell’s equations in a complex coordinate space (to incorporate the PML). For ferromagnetic layers, a fully dispersive modeling of the permeability tensor is implemented to include magnetic losses in a consistent fashion. The numerical results illustrate some striking properties of MPCs, such as wave slowdown (frozen modes), amplitude increase (pulse compression), and unidirectional characteristics. The numerical model is also used to investigate the sensitivity of the MPC response against excitation (frequency and bandwidth), material (ferromagnetic losses), and geometric (layer misalignment and thickness) parameter variations

Indicative and Updated Estimates of the Collective Bargaining Premium in Germany

This study provides updated evidence on the union contract differential in Germany using establishment-wide wage data and two estimation strategies. It provides pairwise estimates of the union differential based on separate samples of collective bargaining leavers and joiners vis-à-vis the corresponding counterfactual groups. It is reported that average wages increase by 3 to 3.5 percent after entering into a collective agreement and decrease by 3 to 4 percent after abandoning a collective agreement. Excluding establishments that experience mass layoffs little influences these net findings, although such establishments record wage losses – statistically insignificant for joiners but up to 10 percent in the case of leavers, as compared with the counterfactuals. The backdrop to these new indicative estimates, which are properly conditioned on establishment size and industry affiliation, inter al., is one of wage stagnation and continuing union decline

Selective Oxidation of Polysulfide Latexes to Produce Polysulfoxide and Polysulfone in a Waterborne Environment

[Image: see text] Polymers containing sulfur centers with high oxidation states in the main chain, polysulfoxide and polysulfone, display desirable properties such as thermomechanical and chemical stability. To circumvent their challenging direct synthesis, methods based on the oxidation of a parent polysulfide have been developed but are plagued by uncontrolled reactions, leading either to ill-defined mixtures of polysulfoxides and polysulfones or to polysulfones with reduced degrees of polymerization due to overoxidation of the polymer. We developed an alternative method to produce well-defined polysulfoxide and polysulfone in a waterborne colloidal emulsion using different oxidants to control the oxidation state of sulfur in the final materials. The direct oxidation of water-based polysulfide latexes avoided the use of volatile organic solvents and allowed for the control of the oxidation state of the sulfur atoms. Oxidation of parent polysulfides by tert-butyl hydroperoxide led to the production of pure polysulfoxides, even after 70 days of reaction time. Additionally, hydrogen peroxide produced both species through the course of the reaction but yielded fully converted polysulfones after 24 h. By employing mild oxidants, our approach controlled the oxidation state of the sulfur atoms in the final sulfur-containing polymer and prevented any overoxidation, thus ensuring the integrity of the polymer chains and colloidal stability of the system. We also verified the selectivity, versatility, and robustness of the method by applying it to polysulfides of different chemical compositions and structures. The universality demonstrated by this method makes it a powerful yet simple platform for the design of sulfur-containing polymers and nanoparticles