Corporate Governance e criação de valor: evidência nas empresas de estrutura acionista familiar cotadas e não cotadas

A temática do Governo das Sociedades tem ganho cada vez mais notoriedade nas duas últimas décadas devido aos vários escândalos financeiros internacionais que provocaram o colapso de grandes empresas. Deste modo, têm sido publicados várias normas e regulamentos com o objetivo de implementar práticas de bom governo. O presente estudo pretende analisar o impacto do Corporate Governance em dez sociedades no período de 2016 a 2018 como um mecanismo para alinhar as metas da gestão com as das partes interessadas que devem aumentar desempenho das empresas familiares portuguesas.The theme of Corporate Governance has increasing notoriety in the last two decades due to the various international financial scandals that caused the collapse of large companies. In this way, several rules and regulations have been published in order to implement good governance practices. This study aims to analyze the impact of Corporate Governance on ten companies in the period from 2016 to 2018 as a mechanism to align management goals with those of stakeholders that should increase the performance of Portuguese family businesses.Mestrado em Finança

Levantamento de Dados de um Estudo Feito pelo PIBID/Química para Analisar a Prova do PAAE

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Very high gravity bioethanol revisited: main challenges and advances

Over the last decades, the constant growth of the world-wide industry has been leading to more and more concerns with its direct impact on greenhouse gas (GHG) emissions. Resulting from that, rising efforts have been dedicated to a global transition from an oil-based industry to cleaner biotechnological processes. A specific example refers to the production of bioethanol to substitute the traditional transportation fuels. Bioethanol has been produced for decades now, mainly from energy crops, but more recently, also from lignocellulosic materials. Aiming to improve process economics, the fermentation of very high gravity (VHG) mediums has for long received considerable attention. Nowadays, with the growth of multi-waste valorization frameworks, VHG fermentation could be crucial for bioeconomy development. However, numerous obstacles remain. This work initially presents the main aspects of a VHG process, giving then special emphasis to some of the most important factors that traditionally affect the fermentation organism, such as nutrients depletion, osmotic stress, and ethanol toxicity. Afterwards, some factors that could possibly enable critical improvements in the future on VHG technologies are discussed. Special attention was given to the potential of the development of new fermentation organisms, nutritionally complete culture media, but also on alternative process conditions and configurations.This work has been carried out at the Biomass and Bioenergy Research Infrastructure (BBRI)- LISBOA-01-0145-FEDER-022059, supported by Operational Programme for Competitive ness and Internationalization (PORTUGAL2020), by Lisbon Portugal Regional Operational Pro gramme (Lisboa 2020) and by North Portugal Regional Operational Program (Norte 2020) under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) and has been supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 and through Project EcoTech (POCI-01-0145- FEDER-032206/ FAPESP 2018/07522-6) funded by the European Regional Development Fund under the scope of Norte2020—Programa Operacional Regional do Norte. The authors also acknowledge the financial support of Research Support Foundation of the state of Minas Gerais-FAPEMIG, National Counsel of Technological and Scientific Development-CNPq and Coordination for the Improvement of Higher Education Personnel-CAPES (Finance Code 001).info:eu-repo/semantics/publishedVersio

Whole grain bread preserved with lemon juice: a comparative study / Pão integral conservado com suco de limão: um estudo comparativo

The use of natural substances for the replacement of chemicals in food conservation is a global trend. Thus, the aim of this study was to evaluate the effect of lemon juice on wholemeal bread conservation and determine shelf time. This is a quantitative, laboratory and explanatory study in which three formulas of the dough with the same composition of ingredients were tested. One formula had the addition of lemon juice at the concentration of 1.75%; other with industrial antifungal at 1.0%; and the last formula without any addition. Analysis of fibers, humidity, pH and titratable acidity were performed. Shelf life for all formulations was evaluated by the visual method until the formation of mold colonies for 5 days. The samples showed similarity in the variation in humidity level (32.4 to 37.9) in relation to time, having a reduction at the first moment and then in the increase of F1 and F2, and F3 remained constant. The  fiber content of the formulations showed a discrepancy between the contents of the evaluated times. The pH of the three formulas was within the desirable range of 4.0 to 7.0 ensuring good quality for the product according to the technical pattern of baking. The acidity variation between formulas followed a common pattern. Shelf life was similar for formulas containing lemon juice and antifungal solution, however the formula without any addition had the shortest shelf time, confirming the efficiency of lemon in the conservation of wholemeal bread.

Effects of concomitant benzodiazepines and antidepressants long-term use on social decision-making: results from the ultimatum game

Benzodiazepines and antidepressants have been shown to change responses to unfairness; however, the effects of their combined use on unfairness evaluation are unknown. This study examines the effects of concomitant benzodiazepines and antidepressants long-term use on the evaluation of fair and unfair offers. To analyze behavioral changes on responses to unfairness, we compared the performance of medicated participants and healthy controls in the Ultimatum Game (UG), both in the proposer and in the respondent role. The results showed that long-term psychotropic users had the worse economic strategy by accepting less offers than control subjects. However, in the proposer role, the unfair offers made by participants were similar between groups. The present results suggest that long-term use of psychotropic medication, specifically the combination of benzodiazepines and antidepressants, may increase the sensitivity to unfairness, resulting in higher rejection rates in conditions where this strategy is the most disadvantageous

Cancer cells’ metabolism dynamics in renal cell carcinoma patients’ outcome: influence of GLUT-1-Related hsa-miR-144 and hsa-miR-186

The cancer cells’ metabolism is altered due to deregulation of key proteins, including glucose transporter 1 (GLUT-1), whose mRNA levels are influenced by microRNAs (miRNAs). Renal cell carcinoma (RCC) is the most common and lethal neoplasia in the adult kidney, mostly due to the lack of accurate diagnosis and follow-up biomarkers. Being a metabolic associated cancer, this study aimed to understand the hsa-miR-144-5p and hsa-miR-186-3p’s potential as biomarkers of clear cell RCC (ccRCC), establishing their role in its glycolysis status. Using three ccRCC lines, the intra- and extracellular levels of both miRNAs, GLUT-1’s mRNA expression and protein levels were assessed. Glucose consumption and lactate production were evaluated as glycolysis markers. A decrease of intracellular levels of these miRNAs and increase of their excretion was observed, associated with an increase of GLUT-1’s levels and glycolysis’ markers. Through a liquid biopsy approach, we found that RCC patients present higher plasmatic levels of hsa-miR-186-3p than healthy individuals. The Hsa-miR144-5p’s higher levels were associated with early clinical stages. When patients were stratified according to miRNAs plasmatic levels, low plasmatic levels of hsa-miR-144-5p and high plasmatic levels of hsa-miR-186-3p (high-risk group) showed the worst overall survival. Thus, circulating levels of these miRNAs may be potential biomarkers of ccRCC prognosis.M.M. and I.N. are recipients of a research scholarship awarded by LPCC-NRN (Portuguese League Against Cancer—Northern Branch). F.D. is a Ph.D. fellow from the project NORTE-01-0145- FEDER-000027, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This project was also funded by the research Center of the Portuguese Oncology Institute of Porto [CI-IPOP-21-2015]

Trypsin purification using magnetic particles of azocasein-iron composite

This work presents an inexpensive, simple and fast procedure to purify trypsin based on affinity binding with ferromagnetic particles of azocasein composite (mAzo). Crude extract was obtained from intestines of fish Nile tilapia (Oreochromis niloticus) homogenized in buffer (01 g tissue/ml). This extract was exposed to 100mg of mAzo and washed to remove unbound proteins by magnetic field. Trypsin was leached off under high ionic strength (3 M NaCl). Preparation was achieved containing specific activity about 60 times higher than that of the crude extract. SDS-PAGE showed that the purified protein had molecular weight (24 kDa) in concordance with the literature for the Nile tilapia trypsin. The mAzo composite can be reused and applied to purify trypsin from other sources.Authors are thankful to CNPq (grant 307273/2013-0) and CAPES (Scholarship to MHMEA) Brazil agencies as well as FCT (Scholarship to SICS and CN) Portugal Agencie

A GEOMETRIA NO ENSINO FUNDAMENTAL 2: dos Parâmetros Curriculares Nacionais à Base Nacional Comum Curricular

Esse artigo é resultado das discussões tecidas ao longo do desenvolvimento da disciplina Ensino e Aprendizagem de Geometria na Educação Básica, ministrada no (contexto identificador - retirado). Com o objetivo de analisar como é proposto o ensino de Geometria nos anos finais do Ensino Fundamental, de acordo com os PCN e a BNCC, e identificar aproximações e distanciamentos entre essas propostas, dialogamos com o referencial teórico metodológico da Hermenêutica de Profundidade, proposto por John B. Thompson, para compreender tanto aspectos internos destes documentos, tais como sua organização, objetivos e propostas relacionadas ao ensino de Geometria por etapas, como também os aspectos relacionados ao contexto social, político e econômico no qual esses documentos foram produzidos e disseminados. Dentre várias discussões acerca desses movimentos, destacamos que alguns conteúdos passaram a figurar em ciclos diferentes, tendo sido antecipados; a BNCC ampliou a abordagem de alguns conceitos e procedimentos ao propor a exploração da descrição de algoritmos para construções geométricas e para a resolução de problemas; ademais, alguns conteúdos que constavam nos PCN dos anos finais do Ensino Fundamental não estão contemplados na BNCC, entretanto, nossos dados são insuficientes para afirmar que estes tenham sido suprimidos, sendo necessário cotejá-los com os PCN dos anos iniciais do Ensino Fundamental e do Ensino Médio, a fim de verificar a possibilidade de estes terem sido antecipados ou postergados

A GEOMETRIA NO ENSINO FUNDAMENTAL 2: dos Parâmetros Curriculares Nacionais à Base Nacional Comum Curricular

Esse artigo é resultado das discussões tecidas ao longo do desenvolvimento da disciplina Ensino e Aprendizagem de Geometria na Educação Básica, ministrada no (contexto identificador - retirado). Com o objetivo de analisar como é proposto o ensino de Geometria nos anos finais do Ensino Fundamental, de acordo com os PCN e a BNCC, e identificar aproximações e distanciamentos entre essas propostas, dialogamos com o referencial teórico metodológico da Hermenêutica de Profundidade, proposto por John B. Thompson, para compreender tanto aspectos internos destes documentos, tais como sua organização, objetivos e propostas relacionadas ao ensino de Geometria por etapas, como também os aspectos relacionados ao contexto social, político e econômico no qual esses documentos foram produzidos e disseminados. Dentre várias discussões acerca desses movimentos, destacamos que alguns conteúdos passaram a figurar em ciclos diferentes, tendo sido antecipados; a BNCC ampliou a abordagem de alguns conceitos e procedimentos ao propor a exploração da descrição de algoritmos para construções geométricas e para a resolução de problemas; ademais, alguns conteúdos que constavam nos PCN dos anos finais do Ensino Fundamental não estão contemplados na BNCC, entretanto, nossos dados são insuficientes para afirmar que estes tenham sido suprimidos, sendo necessário cotejá-los com os PCN dos anos iniciais do Ensino Fundamental e do Ensino Médio, a fim de verificar a possibilidade de estes terem sido antecipados ou postergados