Temperature dependent BCS equations with continuum coupling

The temperature dependent BCS equations are modified in order to include the contribution of the continuum single particle states. The influence of the continuum upon the critical temperature corresponding to the phase transition from a superfluid to a normal state and upon the behaviour of the excitation energy and of the entropy is discussed.Comment: 9 pages, 3 figures, to appear in Phys. Rev.

Randomized controlled field trial to assess the immunogenicity and safety of rift valley fever clone 13 vaccine in livestock

BACKGROUND:Although livestock vaccination is effective in preventing Rift Valley fever (RVF) epidemics, there are concerns about safety and effectiveness of the only commercially available RVF Smithburn vaccine. We conducted a randomized controlled field trial to evaluate the immunogenicity and safety of the new RVF Clone 13 vaccine, recently registered in South Africa. METHODS:In a blinded randomized controlled field trial, 404 animals (85 cattle, 168 sheep, and 151 goats) in three farms in Kenya were divided into three groups. Group A included males and non-pregnant females that were randomized and assigned to two groups; one vaccinated with RVF Clone 13 and the other given placebo. Groups B included animals in 1st half of pregnancy, and group C animals in 2nd half of pregnancy, which were also randomized and either vaccinated and given placebo. Animals were monitored for one year and virus antibodies titers assessed on days 14, 28, 56, 183 and 365. RESULTS:In vaccinated goats (N = 72), 72% developed anti-RVF virus IgM antibodies and 97% neutralizing IgG antibodies. In vaccinated sheep (N = 77), 84% developed IgM and 91% neutralizing IgG antibodies. Vaccinated cattle (N = 42) did not develop IgM antibodies but 67% developed neutralizing IgG antibodies. At day 14 post-vaccination, the odds of being seropositive for IgG in the vaccine group was 3.6 (95% CI, 1.5 - 9.2) in cattle, 90.0 (95% CI, 25.1 - 579.2) in goats, and 40.0 (95% CI, 16.5 - 110.5) in sheep. Abortion was observed in one vaccinated goat but histopathologic analysis did not indicate RVF virus infection. There was no evidence of teratogenicity in vaccinated or placebo animals. CONCLUSIONS:The results suggest RVF Clone 13 vaccine is safe to use and has high (>90%) immunogenicity in sheep and goats but moderate (> 65%) immunogenicity in cattle

The microbiota-gut-brain axis

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson's disease, and Alzheimer's disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders

Philosophy and Information Systems: Where are We and Where Should We Go?

The file attached to this record is the author's final peer reviewed version

The unperceived risk to Europe's coasts: tsunamis and the vulnerability of Cadiz, Spain

The development of appropriate risk and vulnerability reduction strategies to cope with tsunami risks is a major challenge for countries, regions, and cities exposed to potential tsunamis. European coastal cities such as Cadiz are exposed to tsunami risks. However, most official risk reduction strategies as well as the local population are not aware of the probability of such a phenomenon and the potential threat that tsunami waves could pose to their littoral. This paper outlines how tsunami risks, and particularly tsunami vulnerability, could be assessed and measured. To achieve this, a vulnerability assessment framework was applied focusing on the city of Cadiz as a case study in order to highlight the practical use and the challenges and gaps such an assessment has to deal with. The findings yield important information that could assist with the systematic improvement of societal response capacities of cities and their inhabitants to potential tsunami risks. Hazard and vulnerability maps were developed, and qualitative data was obtained through, for example, focused group discussions. These maps and surveys are essential for the development of a people-centred early warning and response system. Therefore, in this regard, the Tsunami Early Warning and Mitigation System in the North Eastern Atlantic, the Mediterranean, and connected seas promoted by the UNESCO-Intergovernmental Oceanographic Commission (IOC) should encompass these assessments to ensure that action is particularly intensified and fostered by those potentially exposed. That means that besides the necessary technical infrastructure for tsunami detection, additional response and adaptation measures need to be promoted – particularly those that reduce the vulnerability of people and regions exposed – in terms of national systems. In addition, it is important to develop emergency preparedness and awareness plans in order to create an integrated regional Tsunami Early Warning System (TEWS) by 2011. The findings of the paper are based on research conducted within the framework of the EC funded project TRANSFER: "Tsunami Risk ANd Strategies For the European Region", a project that aims to improve the understanding of tsunami processes in the Euro-Mediterranean region, to develop methods and tools to assess vulnerability and risk, and to identify strategies for the reduction of tsunami risks