Can Supersymmetry Naturally Explain the Positron Excess?

It has often been suggested that the cosmic positron excess observed by the HEAT experiment could be the consequence of supersymmetric dark matter annihilating in the galactic halo. Although it is well known that evenly distributed dark matter cannot account for the observed excess, if substantial amounts of local dark matter substructure are present, the positron flux would be enhanced, perhaps to the observed magnitude. In this paper, we attempt to identify the nature of the substructure required to match the HEAT data, including the location, size and density of any local dark matter clump(s). Additionally, we attempt to assess the probability of such substructure being present. We find that if the current density of neutralino dark matter is the result of thermal production, very unlikely ($\sim 10^{-4}$ or less) conditions must be present in local substructure to account for the observed excess.Comment: Version accepted by Physical Review

For the Love of It: A Short History of Commercial Fishing in Pacific City, Oregon

Fishermen are often romanticized; they are lonely wanderers separated from the trials of life encountered on dry land. To a commercial fisherman or even someone casually acquainted with the fishing industry, stereotypes seem naïve at best. An examination of the evolving fishery of the Nestucca River and the Pacific Ocean near Pacific City, Oregon, and the careers of seven local fishermen reveals the struggle associated with the calling and the necessity for innovation and adaptation to the changing political, technological, and economic environment. From river netters to ocean trollers, theirs is a story of both persistence and change

Tidal Destruction of The First Dark Microhalos

We point out that the usual self-similarity in cold dark matter models is broken by encounters with individual normal galactic stars on sub-pc scale. Tidal heating and stripping must have redefined the density and velocity structures of the population of the Earth-mass dark matter halos, which are likely to have been the first bound structures to form in the Universe. The disruption rate depends strongly on {\it galaxy types} and the orbital distribution of the microhalos; in the Milky Way, stochastic radial orbits are destroyed first by stars in the triaxial bulge, microhalos on non-planar retrograde orbits with large pericenters and/or apocenters survive the longest. The final microhalo distribution in the {\it solar neighborhood} is better described as a superposition of filamentry microstreams rather than as a set of discrete spherical clumps in an otherwise homogeneous medium. We discuss its important consequences to our detections of microhalos by direct recoil signal and indirect annihilation signal.Comment: 13 pages, 3 figures, Astrophysical Journal, accepte

Non-Competition Agreements and Research Productivity in the Biotechnology Industry

This paper examines the impact of the state-level legal structure, namely the legal support for non-competition agreements, on research productivity. Specifically, we study how California’s unique lack of non-competition agreement laws influences product develop when controlling for local munificence and firm-level technological capability. Our results indicate that California’s unique legal structure is negatively associated with research productivity as measured by the number of products in development at the time a biotechnology firm goes public. Further, firm size moderates this relationship such that the effect is stronger for smaller biotechnology firms

Foreword

Your in-basket is overflowing, your nightstand is piled high with journals, and some articles on your reading list are celebrating birthdays since their date of publication while you struggle to find time to read them. You are already neck-deep in a paper blizzard. So why is the American Economic Association starting another journal

Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.

Background:Acute kidney injury (AKI) commonly occurs in patients with sepsis and acute respiratory distress syndrome (ARDS). Objective:To investigate whether statin treatment is protective against AKI in sepsis-associated ARDS. Design:Secondary analysis of data from Statins for Acutely Injured Lungs in Sepsis (SAILS), a randomized controlled trial that tested the impact of rosuvastatin therapy on mortality in patients with sepsis-associated ARDS. Setting:44 hospitals in the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Patients:644 of 745 participants in SAILS who had available baseline serum creatinine data and who were not on chronic dialysis. Measurements:Our primary outcome was AKI defined using the Kidney Disease Improving Global Outcomes creatinine criteria. Randomization to rosuvastatin vs placebo was the primary predictor. Additional covariates include demographics, ARDS etiology, and severity of illness. Methods:We used multivariable logistic regression to analyze AKI outcomes in 511 individuals without AKI at randomization, and 93 with stage 1 AKI at randomization. Results:Among individuals without AKI at randomization, rosuvastatin treatment did not change the risk of AKI (adjusted odds ratio: 0.99, 95% confidence interval [CI]: 0.67-1.44). Among those with preexisting stage 1 AKI, rosuvastatin treatment was associated with an increased risk of worsening AKI (adjusted odds ratio: 3.06, 95% CI: 1.14-8.22). When serum creatinine was adjusted for cumulative fluid balance among those with preexisting stage 1 AKI, rosuvastatin was no longer associated worsening AKI (adjusted odds ratio: 1.85, 95% CI: 0.70-4.84). Limitations:Sample size, lack of urine output data, and prehospitalization baseline creatinine. Conclusion:Treatment with rosuvastatin in patients with sepsis-associated ARDS did not protect against de novo AKI or worsening of preexisting AKI