72,593 research outputs found
The value relevance of disclosures of liabilities of equity-accounted investees: UK evidence
This study examines the value relevance of mandated disclosures by UK firms of the investor-firm share of liabilities of equity-accounted associate and joint venture investees. It does so for the six years following the introduction of FRS 9: Associates and Joint Ventures, which forced a substantial increase in such disclosures by UK firms. Since the increased disclosure requirements were partly motivated by concern that single-line equity accounting concealed the level of group gearing, and in light of previous US results, it is predicted that the mandated investee-liability disclosures have a negative coefficient in a value-relevance regression. The study also examines whether value-relevance regression coefficients on investee-liability disclosures are more negative for joint ventures than for associates and whether they are more negative in the presence of investor-firm guarantees of investee-firm obligations than in the absence of such guarantees. The study reports that the coefficient on all investee-liability disclosures taken together has the predicted negative sign, and is significantly different from zero. It finds little evidence that the negative valuation impact of liability disclosures is stronger for joint venture investees overall than for associate investees overall, or stronger for guarantee cases overall than for non-guarantee cases overall. There is, however, some evidence that the impact for joint venture guarantee cases is stronger than that for joint venture non-guarantee cases and stronger than that for associate guarantee cases
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The Only Eye Study (OnES): a qualitative study of surgeon experiences of only eye surgery and recommendations for patient safety
OBJECTIVE: Performing surgery on patients with only one seeing-eye, where complications may result in catastrophic vision loss, presents unique challenges for the ophthalmic care team. There is currently no evidence regarding how surgeons augment their care when treating only eye patients and no guidelines for how these patients should be managed in hospital eye services. This study aimed to explore ophthalmic surgeons' experiences of only eye surgery and perceptions of current practice.
DESIGN AND PARTICIPANTS: Ten ophthalmic surgeons were asked to relate their experiences and views on performing only eye surgery in indepth, semistructured interviews. Interviews were audio-recorded and transcribed. Qualitative data were subjected to thematic analysis to identify key themes.
SETTING: Hospital eye service.
RESULTS: Five key themes emerged relating to surgeons' experiences and perceptions of only eye surgery: (1) differences in approach to consent, (2) strategies for risk reduction, (3) unmet training needs, (4) value of surgical mentor and (5) emotional impact of unsuccessful outcomes. Recommendations for improving the surgical journey for both the patient and the surgeon related primarily to better recognition and understanding of the complexities inherent with only eye surgery.
CONCLUSIONS: Outcomes of only eye surgery may be improved through a number of methods, including development of purpose-designed training fellowships, adoption of stress-reducing strategies and enhancement of available support services. The findings identify emerging themes unique to only eye surgery and the need for guidelines on the provision of care for these high-stakes surgical patients
In search of phylogenetic congruence between molecular and morphological data in bryozoans with extreme adult skeletal heteromorphy
peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=tsab20© Crown Copyright 2015. This document is the author's final accepted/submitted version of the journal article. You are advised to consult the publisher's version if you wish to cite from it
Impact of current speed on mass flux to a model flexible seagrass blade
National Science Foundation (U.S.) (Grant EAR 1140970
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Healthy shopper? Blood pressure testing in a shopping centre Pop-Up in England
Background: Improving detection of elevated blood pressure (BP) remains a public health need. We present results from a Pop-Up health check stationed in shopping centres in England. We hypothesise the rate of case detection is related to measurable ‘unhealthiness’ of the shopping centres.
Methods: A Pop-Up health check was sited in four and three shopping centres sampled from the top ten unhealthiest and top 15 healthiest shopping regions respectively, following a report ranking towns/cities based on their unhealthy and healthy retail outlets. On one day in each shopping centre, people were approached and consented to BP testing. Outcome measure was people flagged with BP ≥ 140/90 mmHg (cases).
Results: We detected 45 (22.6%) and 20 (13.1%) cases from testing 199 and 152 adults in the unhealthy and healthy locations respectively (relative risk 1.72; 95% confidence interval: 1.06 to 2.78). A measure of unhealthy retail outlets (e.g. fast-food outlets) within each shopping centre was associated with detection rate (R2 = 0.61; p = 0.04).
Conclusion: An association exists between cases of suspect hypertension found in a health check Pop-Up and measured ‘unhealthiness’ of the shopping centre site. Results hint at strategies for public testing of BP, potentially in the context of reducing health inequalities
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Feeling the pressure: a cross-sectional study exploring feasibility of a healthcare Pop-Up for intraocular pressure measurements in shopping centres in England
OBJECTIVES: To test the hypothesis that a shopping centre Pop-Up health check combining an intraocular pressure (IOP) check with a general health check (blood pressure (BP)) is more readily accepted by the general public than an IOP check only. We investigate public awareness of IOP compared with BP and the feasibility of measuring IOP in large numbers in a Pop-Up. DESIGN: A cross-sectional study using a tailor-made healthcare Pop-Up. SETTING: The 'Feeling the Pressure' Pop-Up was sited in eight regionally-different shopping centres in England. PARTICIPANTS: Adult members of the public in shopping centres. METHODS: On one day we measured IOP only and on another measured BP and IOP. IOP was measured by Icare IC100 tonometer (Helsinki, Finland). Potential participants were asked about their awareness of IOP and BP and when they last visited their optometrist. RESULTS: More people attended the combined BP + IOP days (461; 60%; 95% CI 56% to 64%) than IOP-only days (307; 40%, 95% CI 37% to 43%) over 16 days of testing. We recorded IOP in 652 participants (median (IQR) age and IOP of 54 (42 to 68) years and 13 (11 to 15) mm Hg, respectively). Fewer people reported awareness about IOP (19%, 95% CI 16% to 23%) compared with BP (71%, 95% CI 66% to 75%). Of 768 participants, 60 (8%) reported no previous optometric eye examination and 185 (24%) reported >2 years since their most recent examination. CONCLUSIONS: Measuring IOP in large numbers of the public via a shopping centre Pop-Up is feasible. Public engagement was greater when a BP check was offered alongside an IOP check, suggesting unfamiliar health checks can be promoted by aligning them with a more familiar check. Our findings hint at strategies for public health schemes that engage the public with their eye health
Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda.
BACKGROUND: A six-dose antimalarial regimen of artemether-lumefantrine (A/L) may soon become one of the most widely used drug combination in Africa, despite possible constraints with adherence and poor absorption due to inadequate nutrition, and a lack of pharmacokinetic and effectiveness data. METHODS: Within a trial of supervised versus unsupervised A/L treatment in a stable Ugandan Plasmodium falciparum transmission setting, plasma lumefantrine concentrations were measured in a subset of patients on day 3 (C [lum]day3) and day 7 (C [lum]day7) post-inclusion. Predictors of lumefantrine concentrations were analysed to show how both C [lum]day7 and the weight-adjusted lumefantrine dose affect 28-day recrudescence and re-infection risks. The implications of these novel findings are discussed in terms of the emergence of lumefantrine-resistant strains in Africa. RESULTS: C [lum]day3 and C [lum]day7 distributions among 241 supervised and 238 unsupervised patients were positively skewed. Unsupervised treatment and decreasing weight-adjusted lumefantrine dose were negatively associated with C [lum]day3. Unsupervised treatment and decreasing age showed strong negative associations with C [lum]day7. Both models were poorly predictive (R-squared < 0.25). There were no recrudescences in either arm, but decreasing lumefantrine dose per Kg resulted in up to 13-fold higher adjusted risks of re-infection. Re-infections occurred only among patients with C [lum]day7 below 400 ng/mL (p < 0.001). CONCLUSION: Maintaining the present six-dose regimen and ensuring high adherence and intake are essential to maximize the public health benefits of this valuable drug combination
Mapping the 3-D Dark Matter potential with weak shear
We investigate the practical implementation of Taylor's (2002) 3-dimensional
gravitational potential reconstruction method using weak gravitational lensing,
together with the requisite reconstruction of the lensing potential. This
methodology calculates the 3-D gravitational potential given a knowledge of
shear estimates and redshifts for a set of galaxies. We analytically estimate
the noise expected in the reconstructed gravitational field, taking into
account the uncertainties associated with a finite survey, photometric redshift
uncertainty, redshift-space distortions, and multiple scattering events. In
order to implement this approach for future data analysis, we simulate the
lensing distortion fields due to various mass distributions. We create
catalogues of galaxies sampling this distortion in three dimensions, with
realistic spatial distribution and intrinsic ellipticity for both ground-based
and space-based surveys. Using the resulting catalogues of galaxy position and
shear, we demonstrate that it is possible to reconstruct the lensing and
gravitational potentials with our method. For example, we demonstrate that a
typical ground-based shear survey with redshift limit z=1 and photometric
redshifts with error Delta z=0.05 is directly able to measure the 3-D
gravitational potential for mass concentrations >10^14 M_\odot between
0.1<z<0.5, and can statistically measure the potential at much lower mass
limits. The intrinsic ellipticity of objects is found to be a serious source of
noise for the gravitational potential, which can be overcome by Wiener
filtering or examining the potential statistically over many fields. We examine
the use of the 3-D lensing potential to measure mass and position of clusters
in 3-D, and to detect clusters behind clusters.Comment: 21 pages, including 24 figures, submitted to MNRA
Energy benchmarks for water clusters and ice structures from an embedded many-body expansion
We show how an embedded many-body expansion (EMBE) can be used to calculate
accurate \emph{ab initio} energies of water clusters and ice structures using
wavefunction-based methods. We use the EMBE described recently by Bygrave
\emph{et al.} (J. Chem. Phys. \textbf{137}, 164102 (2012)), in which the terms
in the expansion are obtained from calculations on monomers, dimers, etc. acted
on by an approximate representation of the embedding field due to all other
molecules in the system, this field being a sum of Coulomb and
exchange-repulsion fields. Our strategy is to separate the total energy of the
system into Hartree-Fock and correlation parts, using the EMBE only for the
correlation energy, with the Hartree-Fock energy calculated using standard
molecular quantum chemistry for clusters and plane-wave methods for crystals.
Our tests on a range of different water clusters up to the 16-mer show that for
the second-order M\o{}ller-Plesset (MP2) method the EMBE truncated at 2-body
level reproduces to better than 0.1 m/monomer the correlation energy
from standard methods. The use of EMBE for computing coupled-cluster energies
of clusters is also discussed. For the ice structures Ih, II and VIII, we find
that MP2 energies near the complete basis-set limit reproduce very well the
experimental values of the absolute and relative binding energies, but that the
use of coupled-cluster methods for many-body correlation (non-additive
dispersion) is essential for a full description. Possible future applications
of the EMBE approach are suggested
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