VALUING CHARACTERISTICS OF TRANSFERABLE DEER HUNTING PERMITS IN KANSAS

The novel use of transferable deer hunting permits in Kansas has altered property rights to a traditionally government rationed good, providing the institutional framework and incentives for competitive market activity. This paper investigates how attributes of the permit itself, spatial determinants, and the socioeconomic characteristics of the consumer-hunter influence market price. Findings provide valuable insight into factors that are important to Kansas interest groups, its economy, and to structuring transferable permits for wildlife programs.Resource /Energy Economics and Policy,

Convergence of Eigenvalues for Elliptic Systems on Domains with Thin Tubes and the Green Function for the Mixed Problem

I consider Dirichlet eigenvalues for an elliptic system in a region that consists of two domains joined by a thin tube. Under quite general conditions, I am able to give a rate on the convergence of the eigenvalues as the tube shrinks away. I make no assumption on the smoothness of the coefficients and only mild assumptions on the boundary of the domain. Also, I consider the Green function associated with the mixed problem on a Lipschitz domain with a general decomposition of the boundary. I show that the Green function is Hölder continuous, which shows how a solution to the mixed problem behaves

Voluntary activation of muscle in humans: Does serotonergic neuromodulation matter?

Ionotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the motoneurone, whereas neuromodulatory inputs control the state of excitability of the motoneurone. Intracellular recordings of motoneurones from in vitro and in situ animal preparations have provided extraordinary insight into the mechanisms that underpin how neuromodulators regulate neuronal excitability. However, far fewer studies have attempted to translate the findings from cellular and molecular studies into a human model. In this review, we focus on the role that serotonin (5-HT) plays in muscle activation in humans. 5-HT is a potent regulator of neuronal firing rates, which can influence the force that can be generated by muscles during voluntary contractions. We firstly outline structural and functional characteristics of the serotonergic system, and then describe how motoneurone discharge can be facilitated and suppressed depending on the 5-HT receptor subtype that is activated. We then provide a narrative on how 5-HT effects can influence voluntary activation during muscle contractions in humans, and detail how 5-HT may be a mediator of exercise-induced fatigue that arises from the central nervous system. (Figure presented.)

The mixed problem in Lipschitz domains with general decompositions of the boundary

This paper continues the study of the mixed problem for the Laplacian. We consider a bounded Lipschitz domain $\Omega\subset \reals^n$, $n\geq2$, with boundary that is decomposed as $\partial\Omega=D\cup N$, $D$ and $N$ disjoint. We let $\Lambda$ denote the boundary of $D$ (relative to $\partial\Omega$) and impose conditions on the dimension and shape of $\Lambda$ and the sets $N$ and $D$. Under these geometric criteria, we show that there exists $p_0>1$ depending on the domain $\Omega$ such that for $p$ in the interval $(1,p_0)$, the mixed problem with Neumann data in the space $L^p(N)$ and Dirichlet data in the Sobolev space $W^ {1,p}(D)$ has a unique solution with the non-tangential maximal function of the gradient of the solution in $L^p(\partial\Omega)$. We also obtain results for $p=1$ when the Dirichlet and Neumann data comes from Hardy spaces, and a result when the boundary data comes from weighted Sobolev spaces.Comment: 36 page

5-HT2 receptor antagonism reduces human motoneuron output to antidromic activation but not to stimulation of corticospinal axons

The intrinsic electrical properties of motoneurons strongly affect motoneuron excitability to fast-acting excitatory ionotropic inputs. Serotonin (5-HT) is a neurochemical that alters the intrinsic properties of motoneurons, whereby animal models and in vitro experiments indicate that 5-HT increases motoneuron excitability by activating 5-HT2 receptors on the somato-dendritic compartment. In the current study, we examined how antagonism of the 5-HT2 receptor affects motoneuron excitability in humans. We hypothesised that motoneuron excitability would be reduced. The 5-HT2 antagonist cyproheptadine was administered to 10 healthy participants in a double-blinded, placebo-controlled, crossover trial. Electrical cervicomedullary stimulation was used to deliver a synchronised excitatory volley to motoneurons to elicit cervicomedullary motor evoked potentials (CMEPs) in the surface electromyography (EMG) signal of the resting biceps brachii. Likewise, electrical peripheral nerve stimulation was used to generate antidromic spikes in motoneurons and cause recurrent discharges, which were recorded with surface EMG as F-waves in a resting hand muscle. Compared with placebo, we found that 5-HT2 antagonism reduced the amplitude and persistence of F-waves but did not affect CMEP amplitude. 5-HT2 antagonism also reduced maximal contraction strength. The reduced recurrent discharge of motoneurons with 5-HT2 antagonism suggests that 5-HT2 receptors modulate the electrical properties of the initial segment or soma to promote excitability. Conversely, as cyproheptadine did not affect motoneuron excitability to brief synaptic input, but affected maximal contractions requiring sustained input, it seems likely that the 5-HT2-mediated amplification of synaptic input at motoneuron dendrites is functionally significant only when excitatory input activates persistent inward currents

INVESTIGATING THE USE OF SAMPLE ENTROPY TO DETECT FATIGUE

Sample entropy can sensitively identify changes in biological signal regularity. The aim of this study was to investigate whether sample entropy could detect such change in human movement which may be attributable to fatigue or other factors. The regularity of kettlebell trajectories from simulated kettlebell sport competition performed by five experienced lifters was assessed using a novel moving window technique. Resultant entropy estimate trajectories indicate sensitivity to changes in regularity. Decrements in grip strength indicate this may be attributable to fatigue though other possibilities exist. The ability to easily model the resultant entropy trajectories is also demonstrated. The technique holds potential for use by practitioners though more work is required before implementation

The Economic Impact of Increased Congestion for Freight-Dependent Businesses in Washington State

Congestion in the transportation system necessitates select businesses to operate on a less efficient production function. A survey of freight-dependent businesses in Washington State was used to calculate the costs of congestion and economic impact of increased congestion. As these businesses spend more to provide goods, responses suggest consumers would pay 60% to 80% of the increased cost. Primary areas of increased cost were identified as additional trucking and inventory costs. Results identify an additional $8.7 billion in consumer costs for a 20$3.3 billion in total output and over 27,000 jobs

A Fish Eye Out of Water: Ten Visual Opsins in the Four-Eyed Fish, Anableps anableps

The “four-eyed” fish Anableps anableps has numerous morphological adaptations that enable above and below-water vision. Here, as the first step in our efforts to identify molecular adaptations for aerial and aquatic vision in this species, we describe the A. anableps visual opsin repertoire. We used PCR, cloning, and sequencing to survey cDNA using unique primers designed to amplify eight sequences from five visual opsin gene subfamilies, SWS1, SWS2, RH1, RH2, and LWS. We also used Southern blotting to count opsin loci in genomic DNA digested with EcoR1 and BamH1. Phylogenetic analyses confirmed the identity of all opsin sequences and allowed us to map gene duplication and divergence events onto a tree of teleost fish. Each of the gene-specific primer sets produced an amplicon from cDNA, indicating that A. anableps possessed and expressed at least eight opsin genes. A second PCR-based survey of genomic and cDNA uncovered two additional LWS genes. Thus, A. anableps has at least ten visual opsins and all but one were expressed in the eyes of the single adult surveyed. Among these ten visual opsins, two have key site haplotypes not found in other fish. Of particular interest is the A. anableps-specific opsin in the LWS subfamily, S180γ, with a SHYAA five key site haplotype. Although A. anableps has a visual opsin gene repertoire similar to that found in other fishes in the suborder Cyprinodontoidei, the LWS opsin subfamily has two loci not found in close relatives, including one with a key site haplotype not found in any other fish species. A. anableps opsin sequence data will be used to design in situ probes allowing us to test the hypothesis that opsin gene expression differs in the distinct ventral and dorsal retinas found in this species

Revision of Madagascar's Dwarf Lemurs (Cheirogaleidae:Cheirogaleus): Designation of Species, Candidate Species Status and Geographic Boundaries Based on Molecular and Morphological Data

The genus Cheirogaleus, the dwarf lemurs, is a radiation of strepsirrhine primates endemic to the island of Madagascar. The dwarf lemurs are taxonomically grouped in the family Cheirogaleidae (Infraorder: Lemuriformes) along with the genera Microcebus, Mirza, Allocebus, and Phaner. The taxonomic history of the genus Cheirogaleus has been controversial since its inception due to a paucity of evidence in support of some proposed species. In this study, we addressed this issue by expanding the geographic breadth of samples by 91 individuals and built upon existing mitochondrial (cytb and COII) and nuclear (FIBA and vWF) DNA datasets to better resolve the phylogeny of Cheirogaleus. The mitochondrial gene fragments D-loop and PAST as well as the CFTR-PAIRB nuclear loci were also sequenced. In agreement with previous genetic studies, numerous deep divergences were resolved in the C. major, C. minor and C. medius lineages. Four of these lineages were segregated as new species, seven were identified as confirmed candidate species, and four were designated as unconfirmed candidate species based on comparative mitochondrial DNA sequence data gleaned from the literature or this study. Additionally, C. thomasi was resurrected. Given the widespread distribution of the genus Cheirogaleus throughout Madagascar, the methodology employed in this study combined all available lines of evidence to standardize investigative procedures in a genus with limited access to type material and a lack of comprehensive sampling across its total distribution. Our results highlighted lineages that likely represent new species and identified localities that may harbor an as-yet undescribed cryptic species diversity pending further field and laboratory work.We are most grateful to the Ahmanson Foundation, the Theodore F. and Claire M. Hubbard Family Foundation, the Primate Action Fund / Conservation International, the Margot Marsh Biodiversity Foundation, and the National Geographic Society, for financial assistance