Unwrapping the Comfort of Sameness With Spanish Immersion Elementary School

I watched my 6-year-old hover around the periphery of the table, unable to find somewhere to sit. The cafeteria was a cacophony of little voices, Spanish and English, tumbling over each other, her classmates sitting close and waiting to be dismissed to homeroom. I couldn’t help but notice how different Noelle looked from most of the children, with her liquid blond hair and saucerlike blue eyes. [excerpt

Jesus Lives, but Should He Live in My Front Yard?

As I drove home from church, I eyed the bright foam sign my 6-year-old daughter held. “Jesus is Alive” it read in kid scrawl. “We’re supposed to put them in our yards!” Noelle beamed, eyeing her creation proudly through pink-rimmed glasses. I imagined our wide, open yard in Pennsylvania, the green grass stretching without fences from one neighbor to the next. Our best friends in the neighborhood, secular humanists, would easily see it. I cringed. What would they think? [excerpt

Crew: Finding Community When Your Dreams Crash

Most young adults at some point experience a personal shipwreck —missing out on the job you wanted, the unexpected end of a relationship, a crisis of faith—that threatens to rip apart the fabric of your identity. What helps navigate a personal shipwreck is to have a crew of reliable people who walk with you through it. In Crew: Finding Community When Your Dreams Crash, Christin Taylor explores how young adults can both find good company during a time of personal shipwreck and be good company for others who might be experiencing their own shipwreck. In the process, you will learn the hope and security that comes from being part of a community. Based on sound scriptural principles and the latest research on young adult spiritual formation, Taylor gives young adults the knowledge and perspective you need to build a community that will help you make your way toward a sense of hope and new meaning. [From the publisher]https://cupola.gettysburg.edu/books/1059/thumbnail.jp

7 Things Churches Can Do to Make Queer People Feel Welcome

For as long as I can remember, the church, for me, has been a place characterized by shame and hurt. I remember Christian high school friends telling me that I would go to hell for being Queer. I remember hearing sermons from televangelists about the evils of homosexuality, and church leaders pressuring youth leaders to cast out their Queer members. I\u27ve heard more talk of love the sinner, hate the sin, and God didn\u27t make gay, than anyone should, and I\u27ve even received personalized hate mail declaring that God hates dykes. [excerpt

Shipwrecked in L.A.: Finding Meaning and Purpose When Your Dreams Crash

Most young adults encounter at least one shipwreck during their twenties. Everything you think you know about yourself, your life, your future, and even your faith suddenly breaks apart. You\u27re left scrambling to construct a lifeboat that will take you back to the shore. Christin Taylor knew how her life was going to turn out. She was going to be a missionary to the Hollywood film industry. But just eight weeks after moving to L.A., her hopes and dreams were shattered. The next four years found Christin circling around, into, and back out of the film industry, until she finally found her way home. As Christin shares a compelling story about her life and work in Burbank, Hollywood, and Beverly Hills, she interacts with the best research on young-adult formation and development, guiding young adults through this tumultuous time as they try to pick up the pieces and find hope for the future. [From the Publisher]https://cupola.gettysburg.edu/books/1015/thumbnail.jp

Rubisco evolution in C₄ eudicots: an analysis of Amaranthaceae sensu lato.

BACKGROUND: Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase) catalyses the key reaction in the photosynthetic assimilation of CO₂. In C₄ plants CO₂ is supplied to Rubisco by an auxiliary CO₂-concentrating pathway that helps to maximize the carboxylase activity of the enzyme while suppressing its oxygenase activity. As a consequence, C₄ Rubisco exhibits a higher maximum velocity but lower substrate specificity compared with the C₃ enzyme. Specific amino-acids in Rubisco are associated with C₄ photosynthesis in monocots, but it is not known whether selection has acted on Rubisco in a similar way in eudicots. METHODOLOGY/PRINCIPAL FINDINGS: We investigated Rubisco evolution in Amaranthaceae sensu lato (including Chenopodiaceae), the third-largest family of C₄ plants, using phylogeny-based maximum likelihood and Bayesian methods to detect Darwinian selection on the chloroplast rbcL gene in a sample of 179 species. Two Rubisco residues, 281 and 309, were found to be under positive selection in C₄ Amaranthaceae with multiple parallel replacements of alanine by serine at position 281 and methionine by isoleucine at position 309. Remarkably, both amino-acids have been detected in other C₄ plant groups, such as C₄ monocots, illustrating a striking parallelism in molecular evolution. CONCLUSIONS/SIGNIFICANCE: Our findings illustrate how simple genetic changes can contribute to the evolution of photosynthesis and strengthen the hypothesis that parallel amino-acid replacements are associated with adaptive changes in Rubisco

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment