Osteonecrosis of the Jaw in a Patient Taking Once-Yearly Infusion of Zoledronic Acid for Osteopenia

Osteonecrosis of the jaw (ONJ) is an adverse effect of nitrogen-containing bisphosphonates. Advancing age, intravenous administration of zoledronic acid (ZOL), history of dento-alveolar surgery, and concomitant systemic diseases such as diabetes are known as risk factors for developing ONJ. However, despite numerous studies, the exact pathophysiology remains unclear and management strategies are largely anecdotal. Once-yearly intravenously administered 5 mg ZOL was approved by the US Food and Drug Administration in 2007 for the treatment of osteoporosis and its efficacy with 3 year-regimen had been recently been proven in preventing new clinical fracture. Although occurrences of ONJ have been reported to be rare with this drug administration, available data is very limited and long-term outcomes are lacking. We present a case of ONJ identified in an osteopenic patient with an intermittent but long standing sore mouth related to exposed mandibular bone. Once-yearly infusion of zoledronic acid used in the treatment of osteopenia may contribute to the spontaneous development of ONJ, especially in those presenting with multiple comorbidity factors. This report suggests the importance of health care professionals keeping abreast of new developments in this area and providing appropriate information to their patients

Ventilating the Box Cut of a Two-Pass 40-ft Extended Cut

On a continuous miner coal face methane concentrations are affected by the quantity of fresh intake air reaching the face. When mining the box cut on a 12.2-m (40-ft) two-pass extended cut face, the continuous miner is always at the point of deepest penetration, and operation of the machine-mounted dust scrubber and water spray system improve the flow of fresh air to the end of the box cut. However, when the continuous miner leaves the box cut to begin cutting the 40-ft slab, little is known about how much ventilation air reaches the end of the box cut. The Pittsburgh Research Laboratory (PRL) of the National Institute for Occupational Safety and Health conducted a full-scale study to answer this question. Tests were run to determine how much ventilation air reaches the end of the box cut with the continuous miner at three locations in the 40-ft two-pass extended cut mining sequence; at the end of the 40-ft box cut, at the start of the 40-ft slab cut, and 6.1 m (20ft) into the slab cut. During these tests, methane gas was uniformly released at the end of the 40-ft box cut. Methane concentrations measured 0.3 m (1 ft) from the roof and face of the box cut were used to estimate face airflow quantities. Fresh airflow rates of 1.89 and 4. 72 m3/sec (4,000 and 10.000 cfm), scrubber flow rates of 0, 4,000 and 10,000 cfm, water spray pressures of 0 and 827 kPa (0 and 120 psi), and a blowing curtain setback position of 15.2 m (50ft) were used during these tests. To improve ventilation to the end of the 40-ft box cut when the continuous miner was starting the 40-ft slab cut and 20ft into the slab cut, the blowing curtain was advanced from its 50-ft setback to locations 40-ft and then 8.5 m (28ft) from the face

Teaching and understanding of quantum interpretations in modern physics courses

Just as expert physicists vary in their personal stances on interpretation in quantum mechanics, instructors vary on whether and how to teach interpretations of quantum phenomena in introductory modern physics courses. In this paper, we document variations in instructional approaches with respect to interpretation in two similar modern physics courses recently taught at the University of Colorado, and examine associated impacts on student perspectives regarding quantum physics. We find students are more likely to prefer realist interpretations of quantum-mechanical systems when instructors are less explicit in addressing student ontologies. We also observe contextual variations in student beliefs about quantum systems, indicating that instructors who choose to address questions of ontology in quantum mechanics should do so explicitly across a range of topics.Comment: 18 pages, references, plus 2 pages supplemental materials. 8 figures. PACS: 01.40.Fk, 03.65.-

Consumption of Whole Cottonseed by White-Tailed Deer and Nontarget Species

Supplementing diets of white-tailed deer (Odocoileus virginianus) with pelleted rations is an increasingly common practice aimed at increasing deer antler size on rangelands in Texas. Feed loss to consumption by various nontarget species (e.g., raccoons [Procyon lotor] and feral pigs [Sus scrofa]) raises both ecological and economic concerns. Whole cottonseed is a feedstuff that may afford a more targeted supplemental feeding effort. Accordingly, we determined: (1) consumption rates of whole cottonseed by feral pigs and raccoons in captivity; and (2) species visitation at feed sites and preference for whole cottonseed relative to whole corn under field conditions. For experiments 1 and 2, we trapped subadult feral pigs and raccoons (n = 16 for each) and randomly assigned them to 4 feed treatments. We weighed and took blood to assess gossypol levels from both pigs and raccoons every 2 weeks for 2 months. Pigs were adept at sorting cottonseed from their feed ration in the laboratory trial. Raccoons consumed cottonseed only under severe dietary stress (i.e., diets reduced to 60% of maintenance requirements). To supplement laboratory findings we used motion-triggered video camera systems to monitor species visitation and feeding behaviors in the field. Video surveillance (125 hours of recorded events) of feeders supported our observations from laboratory trials that cottonseed was unpalatable to feral pigs and raccoons, whereas white-tailed deer consumed cottonseed readily. Given our results, we believe that whole cottonseed merits further consideration as a supplement for free-ranging deer

A response to “Likelihood ratio as weight of evidence: a closer look” by Lund and Iyer

Recently, Lund and Iyer (L&I) raised an argument regarding the use of likelihood ratios in court. In our view, their argument is based on a lack of understanding of the paradigm. L&I argue that the decision maker should not accept the expert’s likelihood ratio without further consideration. This is agreed by all parties. In normal practice, there is often considerable and proper exploration in court of the basis for any probabilistic statement. We conclude that L&I argue against a practice that does not exist and which no one advocates. Further we conclude that the most informative summary of evidential weight is the likelihood ratio. We state that this is the summary that should be presented to a court in every scientific assessment of evidential weight with supporting information about how it was constructed and on what it was based