A COMPARISON OF SPRINT TECHNIQUE BETWEEN PROFESSIONAL FOOTBALL PLAYERS AND ELITE SPRINTERS

This study compared sprint technique between professional footballer players and elite sprinters. Professional football players sprint technique was assessed using 2D video analysis and compared to publicly available data of elite sprinters from the IAAF biomechanical reports. Results showed sprinters had higher step frequencies and contacted the ground further back, with lower touchdown and higher toe-off distances

Hand-dug Well Water Quality: The Case of Two Peri-Urban Communities in Ghana

Many rural and peri-urban areas in developing countries including Ghana face challenges with access to good quality drinking water. These areas often depend on surface water or ground water sources which are often compromised with excess levels of nitrate, chloride and microbial pathogens. This study sought to assess the effect of household latrine system on household water quality of two peri-urban communities in the Upper West Region of Ghana. Geographic Information Systems were used to map the latrine location and elevation of household wells relative to latrines. Latrines and wells were visually inspected. Water samples were also collected from the selected household wells and tested for pH, chlorine, turbidity, colour, conductivity, temperature, total dissolved solids, nitrites and nitrates. Selected community borehole water were used for controls. The study showed average latrine location relative to household well was 13.7 m. The difference in elevation between the wells and latrines is at an average of 0.7m. All the household latrines were improved latrines and household wells with 47% of them having lids to cover them. The water quality observed were all within the WHO drinking water quality for the physicochemical parameters assessed. The study however showed higher levels of nitrate in household wells than bore holes. The need to educate households in locating of Kraals relative to household water systems is needed. Further studies including environmental and geological assessments are required to establish the observations made regarding why areas of high latrine concentrations had lower nitrate levels. Also microbiological studies to establish the safety of water for drinking is required

Prevalence of Snail Vectors of Schistosomiasis in the Kpong Head Pond, Ghana

Schistosomiasis, a parasitic disease caused by the blood fluke Schistosoma sp. became a serious public health problem in Ghana after the Volta River was dammed in Akosombo in 1964. The formation of the Kpong head pond, about 25 km below the Akosombo dam, as a result of a second dam built at Kpong became an active schistosomiasis transmission site. The Volta River Authority (VRA) recently began an initiative of combining manual clearing of aquatic vegetation with chemotherapy as a way of managing the disease. However, no scientific monitoring of the effect of aquatic weed clearing on the vector population is being conducted. The study was initiated in the Kpong head pond to provide baseline data for subsequent monitoring and impact assessment of the initiative. It involved sampling of the banks of the head pond for aquatic snails at six different sampling sites of 1 m2 each, chosen at 100 m interval along the shoreline. Physicochemical factors which affect aquatic snail population were also determined. Aquatic snails sampled were Bulinus truncatus, Bulinus globosus, Biomphalaria pfeifferi, Melanoides spp, Physa waterlotti and Pila sp. where the first three are intermediate host of the schistosoma parasite. The study revealed B. truncates as the most frequent occurring vector (71.0%), followed by Biomphalaria (12.0%) and B. globosus (6.1%) The mean numbers of vector snails sampled per m2 were B. Truncates 61/m2, B. globosus 5/m2, and B. pfeifferi 11/m2. The presence of aquatic weeds and favourable physicochemical conditions of the water were found to provide a conducive environment for the vectors to thrive and hence sustain schistosomiasis transmission in the head pond. It is, therefore, recommended that a 5-year period of studies be undertaken to assess the impact of manual clearing of aquatic weeds on the snail population

Partisan political connections, ethnic tribalism, and firm performance

This paper investigates the impact of partisan political connections and ethnic tribalism on firm performance in a hyper-partisan political environment. Although existing literature generally shows that political connections improve firm performance, we argue that under the theory of electoral competition, political connections can be a double-edged sword because of the tension of partisan politics. Hence, we expect that changes in government can affect firm performance. Using a unique dataset from Nigeria, we find that political connections are valuable when a firm's patron party is in power, whereas they are detrimental to firm value when their patron party is in opposition. Furthermore, we find that CEO ethnic tribal affiliation with the President improves firm performance even when the firm's patron party is in opposition. This paper extends the literature on political connections and helps managers and policymakers understand the timely use of political connections in a hyper-partisan environment

Determinants of green growth in developed and developing countries.

Considering the need for environmental sustainability while ensuring economic growth and development by 2030, this study uses data on 123 developed and developing countries to examine factors that influence green growth. The empirical results show that economic development positively influences green growth. However, trade openness is detrimental to green growth. Regarding energy-related factors, we find energy consumption negatively affecting green growth, but renewable energy consumption significantly improves green growth. In further analysis, we find that the influence of these factors differs between developed and developing countries. The result implies that countries at a different development level will require different strategies in achieving the Sustainable Development Goals in 2030. The results are robust to alternative identification strategies such as the System Generalised Method of Movement, which accounts for potential endogeneity

Representation of Africa online: sourcing practice and frames of reference

The dominant perspective on the representation of Africa in the western media claims that western media coverage is bias and crisis orientated and the liberal perspective claims that the coverage of Africa is not as negative as is often assumed. However, there is a paucity of literature on the representation of Africa online. This research enquiry is relevant because literature claims that the Internet has the potential to resolve the journalistic predicament of representing other culture through political participation and deliberation. But this requires a re-orientation of the sourcing practice of news organization to embrace sensitivity to and knowledge of African cultures. Moreover, the journalistic predicament can be resolved or not depending on the news gathering approach adopted by the news organization. Literature has identified two approaches, that is, ‘gatekeeping’ used mainly by dominant traditional media and ‘gatewatching’ used by alternative media in their quest to counter mainstream ideology. This study examines the impacts of the ‘gatewatching’ approach adopted by Africa Have Your Say (AHYS) website on its representation and frames of reference of Africa. It uses on-site observation, in-depth interviews and textual analysis to gather data. The study found that although the sourcing practice at the AHYS is elaborate and complex, the ‘gatewatching’ approach makes its susceptible to second level agenda setting. Hence, its frame repeats the attributes and tone used by the mainstream traditional media. However, a minority of users did not use repeat this frame in their comments

A novel ruthenium-silver based antimicrobial potentiates aminoglycoside activity against Pseudomonas aeruginosa

The rapid dissemination of antibiotic resistance combined with the decline in the discovery of novel antibiotics represents a major challenge for infectious disease control that can only be mitigated by investments in novel treatment strategies. Alternative antimicrobials, including silver, have regained interest due to their diverse mechanisms of inhibiting microbial growth. One such example is AGXX, a broad-spec­trum antimicrobial that produces highly cytotoxic reactive oxygen species (ROS) to inflict extensive macromolecular damage. Due to the connections identified between ROS production and antibiotic lethality, we hypothesized that AGXX could potentially increase the activity of conventional antibiotics. Using the gram-negative pathogen Pseudomonas aeruginosa, we screened possible synergistic effects of AGXX on several antibiotic classes. We found that the combination of AGXX and aminoglycosides tested at sublethal concentrations led to a rapid exponential decrease in bacterial survival and restored the sensitivity of a kanamycin-resistant strain. ROS production contributes significantly to the bactericidal effects of AGXX/aminoglycoside treatments, which is dependent on oxygen availability and can be reduced by the addition of ROS scaveng­ers. Additionally, P. aeruginosa strains deficient in ROS detoxifying/repair genes were more susceptible to AGXX/aminoglycoside treatment. We further demonstrate that this synergistic interaction was associated with a significant increase in outer and inner membrane permeability, resulting in increased antibiotic influx. Our study also revealed that AGXX/aminoglycoside-mediated killing requires an active proton motive force across the bacterial membrane. Overall, our findings provide an understanding of cellular targets that could be inhibited to increase the activity of conventional antimicrobial

Profile and outcomes of hospitalized patients with COVID-19 at a tertiary institution hospital in Ghana

Background: In high-income countries, mortality related to hospitalized patients with the Coronavirus disease 2019 (COVID-19) is approximately 4-5%. However, data on COVID-19 admissions from sub-Saharan Africa are scanty.Objective: To describe the clinical profile and determinants of outcomes of patients with confirmed COVID-19 admitted at a hospital in Ghana.Methods: A prospective study involving 25 patients with real time polymerase chain reaction confirmed COVID-19 admitted to the treatment centre of the University Hospital, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana from 1st June to 27th July, 2020. They were managed and followed up for outcomes. Data were analysed descriptively, and predictors of mortality assessed using a multivariate logistic regression modelling.Results: The mean age of the patients was 59.3 ± 20.6 years, and 14 (56%) were males. The main symptoms at presentation were breathlessness (68%) followed by fever (56%). The cases were categorized as mild (6), moderate (6), severe (10) and critical (3). Hypertension was the commonest comorbidity present in 72% of patients. Medications used in patient management included dexamethasone (68%), azithromycin (96%), and hydroxychloroquine (4%). Five of 25 cases died (Case fatality ratio 20%). Increasing age and high systolic blood pressure were associated with mortality.Conclusion: Case fatality in this sample of hospitalized COVID-19 patients was high. Thorough clinical assessment, severity stratification, aggressive management of underlying co-morbidities and standardized protocols incountry might improve outcomes

Cost and cost-eff ectiveness of newborn home visits: fi ndings from the Newhints cluster-randomised controlled trial in rural Ghana

Background Every year, 2·9 million newborn babies die worldwide. A meta-analysis of four cluster-randomised controlled trials estimated that home visits by trained community members in programme settings in Ghana and south Asia reduced neonatal mortality by 12% (95% CI 5–18). We aimed to estimate the costs and cost-eff ectiveness of newborn home visits in a programme setting. Methods We prospectively collected detailed cost data alongside the Newhints trial, which tested the eff ect of a homevisits intervention in seven districts in rural Ghana and showed a reduction of 8% (95% CI –12 to 25%) in neonatal mortality. The intervention consisted of a package of home visits to pregnant women and their babies in the fi rst week of life by community-based surveillance volunteers. We calculated incremental cost-eff ectiveness ratios (ICERs) with Monte Carlo simulation and one-way sensitivity analyses and characterised uncertainty with cost-eff ectiveness planes and cost-eff ectiveness acceptability curves. We then modelled the potential cost-eff ectiveness for baseline neonatal mortality rates of 20–60 deaths per 1000 livebirths with use of a meta-analysis of eff ectiveness estimates. Findings In the 49 zones randomly allocated to receive the Newhints intervention, a mean of 407 (SD 18) communitybased surveillance volunteers undertook home visits for 7848 pregnant women who gave birth to 7786 live babies in 2009. Annual economic cost of implementation was US$203 998, or$0·53 per person. In the base-case analysis, the Newhints intervention cost a mean of $10 343 (95$352 (95% CI 104 to –268) per discounted life-year saved, and had a 72% chance of being highly cost eff ective with respect to Ghana’s 2009 gross domestic product per person. Key determinants of cost-eff ectiveness were the discount rate, protective eff ectiveness, baseline neonatal mortality rate, and implementation costs. In the scenarios modelled with the meta-analysis results, the ICER increased from $127 per life-year saved at a neonatal mortality rate of 60 deaths per 1000 livebirths, to$379 per life-year saved at a rate of 20 deaths per 1000 livebirths. The strategy had at least a 99% probability of being highly cost eff ective for lower-middle-income countries in all neonatal mortality rate scenarios modelled, and at least a 95% probability of being highly cost eff ective for low-income countries at neonatal mortality rates of 30 or more deaths per 1000 livebirths. Interpretation Our fi ndings show that the seemingly modest mortality reductions achieved by a newborn home-visit strategy might in fact be cost eff ective. In Ghana, such strategies are also likely to be aff ordable. Our fi ndings support recommendations from WHO and UNICEF that low-income and middle-income countries implement newborn home visits

Implementing effective community-based surveillance in research studies of maternal, newborn and infant outcomes in low resource settings

BACKGROUND: Globally adopted health and development milestones have not only encouraged improvements in the health and wellbeing of women and infants worldwide, but also a better understanding of the epidemiology of key outcomes and the development of effective interventions in these vulnerable groups. Monitoring of maternal and child health outcomes for milestone tracking requires the collection of good quality data over the long term, which can be particularly challenging in poorly-resourced settings. Despite the wealth of general advice on conducting field trials, there is a lack of specific guidance on designing and implementing studies on mothers and infants. Additional considerations are required when establishing surveillance systems to capture real-time information at scale on pregnancies, pregnancy outcomes, and maternal and infant health outcomes. MAIN BODY: Based on two decades of collaborative research experience between the Kintampo Health Research Centre in Ghana and the London School of Hygiene and Tropical Medicine, we propose a checklist of key items to consider when designing and implementing systems for pregnancy surveillance and the identification and classification of maternal and infant outcomes in research studies. These are summarised under four key headings: understanding your population; planning data collection cycles; enhancing routine surveillance with additional data collection methods; and designing data collection and management systems that are adaptable in real-time. CONCLUSION: High-quality population-based research studies in low resource communities are essential to ensure continued improvement in health metrics and a reduction in inequalities in maternal and infant outcomes. We hope that the lessons learnt described in this paper will help researchers when planning and implementing their studies