Nutraceutic Food: Testing The Consumer’s WTP for Sunflower PUFA Oil

Nutraceutical foods are supposed to procure medical or health benefits beyond the effects of nutrients compounds alone. However, few of them are accompanied by convincing health claims, as the response to nutraceutical components varies from subject to subject, depends on the concentration of bioactive components and their efficacy must be tested in repeated clinical trials. Many medical studies have proved the non-substitutable roles of polyunsaturated essential fatty acids (PUFA) in many biological and regulatory patterns. The purpose of this research is to test the consumers’ attitude to sunflower PUFA oil and their willingness to pay (WTP) a premium price for the quality of this nutraceutical food. The inference is based on the Structural Equation Modeling (SEM) able to capture the complexity of credence quality of this nutraceutical oil to influence the customer decisions. A survey with “ad hoc” questionnaire using CASI technique was submitted to a sample of consumers located in the northeast region FVG in Italy. The results confirmed the two above hypotheses and suggested to frame the communication strategy according with claim regulation to strengthen the customization for PUFA sunflower oil

Il boom del Distretto del Prosecco: immagine dell'utilit\ue0 dell'inutile tra austerit\ue0 e ripresa

The industrial districts have given rise to a variety of biocultural paths, but in the post-industrial era these are continuously threatened by the trend towards product standardisation. Despite this, local districts are able to survive, albeit in a weakened state, with two possible effects: A) the risk of fading; B) the desirability of resilience. The Biocultural fingerprint of the Prosecco District (placed 3rd in the Intesa San Paolo ranking of Italian districts for 2008-2011) reveals that its clusters of municipalities are characterised by agricultural and eno-gastronomic excellence in both rural and urban contexts. Meanwhile, its tourist attractiveness index, owing to its lack of apparently "useless components" such as nature parks and protected areas, and cultural heritage, is relatively low. It follows that the marketing-image strategies devised for immediate profit appear to be insufficient at coping with the competition and ensuring a sustained level of development in the long term

From stem and progenitor cells to neurons in the developing neocortex: Key differences among hominids

Comparing the biology of humans to that of other primates, and notably other hominids, is a useful path to learn more about what makes us human. Some of the most interesting differences among hominids are closely related to brain development and function, for example behaviour and cognition. This makes it particularly interesting to compare the hominid neural cells of the neocortex, a part of the brain that plays central roles in those processes. However, well-preserved tissue from great apes is usually extremely difficult to obtain. A variety of new alternative tools, for example brain organoids, are now beginning to make it possible to search for such differences and analyse their potential biological and biomedical meaning. Here, we present an overview of recent findings from comparisons of the neural stem and progenitor cells (NSPCs) and neurons of hominids. In addition to differences in proliferation and differentiation of NSPCs, and maturation of neurons, we highlight that the regulation of the timing of these processes is emerging as a general foundational difference in the development of the neocortex of hominids

Fusion PET-CT imaging of neurolymphomatosis

In a patient suffering from peripheral neuropathy due to neurolymphomatosis, fused PET-CT imaging, performed on a novel in-line PET-CT system, showed multiple small nodular lesions extending along the peripheral nerves corresponding to an early relapse of a transformed B-cell non-Hodgkin's lymphom

A strong X-ray polarization signal from the magnetar 1RXS J170849.0-400910

Magnetars are the most strongly magnetized neutron stars, and one of the most promising targets for X-ray polarimetric measurements. We present here the first Imaging X-ray Polarimetry Explorer observation of the magnetar 1RXS J170849.0-400910, jointly analyzed with a new Swift observation and archival NICER data. The total (energy- and phase-integrated) emission in the 2–8 keV energy range is linerarly polarized, at a ∼35% level. The phase-averaged polarization signal shows a marked increase with energy, ranging from ∼20% at 2–3 keV up to ∼80% at 6–8 keV, while the polarization angle remains constant. This indicates that radiation is mostly polarized in a single direction. The spectrum is well reproduced by a combination of either two thermal (blackbody) components or a blackbody and a power law. Both the polarization degree and angle also show a variation with the spin phase, and the former is almost anticorrelated with the source counts in the 2–8 and 2–4 keV bands. We discuss the possible implications and interpretations, based on a joint analysis of the spectral, polarization, and pulsation properties of the source. A scenario in which the surface temperature is not homogeneous, with a hotter cap covered by a gaseous atmosphere and a warmer region in a condensed state, provides a satisfactory description of both the phase- and energy-dependent spectro-polarimetric data. The (comparatively) small size of the two emitting regions, required to explain the observed pulsations, does not allow to reach a robust conclusion about the presence of vacuum birefringence effects

Electron localization and possible phase separation in the absence of a charge density wave in single-phase 1T-VS2_2

We report on a systematic study of the structural, magnetic and transport properties of high-purity 1T-VS$_2$ powder samples prepared under high pressure. The results differ notably from those previously obtained by de-intercalating Li from LiVS$_2$. First, no Charge Density Wave (CDW) is found by transmission electron microscopy down to 94 K. Though, \textit{ab initio} phonon calculations unveil a latent CDW instability driven by an acoustic phonon softening at the wave vector ${\bf q}_{CDW} \approx$ (0.21,0.21,0) previously reported in de-intercalated samples. A further indication of latent lattice instability is given by an anomalous expansion of the V-S bond distance at low temperature. Second, infrared optical absorption and electrical resistivity measurements give evidence of non metallic properties, consistent with the observation of no CDW phase. On the other hand, magnetic susceptibility and NMR data suggest the coexistence of localized moments with metallic carriers, in agreement with \textit{ab initio} band structure calculations. This discrepancy is reconciled by a picture of electron localization induced by disorder or electronic correlations leading to a phase separation of metallic and non-metallic domains in the nm scale. We conclude that 1T-VS$_2$ is at the verge of a CDW transition and suggest that residual electronic doping in Li de-intercalated samples stabilizes a uniform CDW phase with metallic properties.Comment: 22 pages, 10 Figures. Full resolution pictures available at http://journals.aps.org/prb/abstract/10.1103/PhysRevB.89.23512

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity

The goal of this study was to understand if exosomes derived from high-metastatic cells may influence the behavior of less aggressive cancer cells and the properties of the endothelium. We found that metastatic colon cancer cells are able to transfer their amoeboid phenotype to isogenic primary cancer cells through exosomes, and that this morphological transition is associated with the acquisition of a more aggressive behavior. Moreover, exosomes from the metastatic line (SW620Exos) exhibited higher ability to cause endothelial hyperpermeability than exosomes from the non metastatic line (SW480Exos). SWATH-based quantitative proteomic analysis highlighted that SW620Exos are significantly enriched in cytoskeletal-associated proteins including proteins activating the RhoA/ROCK pathway, known to induce amoeboid properties and destabilization of endothelial junctions. In particular, thrombin was identified as a key mediator of the effects induced by SW620Exos in target cells, in which we also found a significant increase of RhoA activity. Overall, our results demonstrate that in a heterogeneous context exosomes released by aggressive sub-clones can contribute to accelerate tumor progression by spreading malignant properties that affect both the tumor cell plasticity and the endothelial cell behavior

A Computational Study to Identify TP53 and SREBF2 as Regulation Mediators of miR-214 in Melanoma Progression

In the complex world of post-transcriptional regulation, miR-214 is known to control in vitro tumor cell move- ment and survival to anoikis, as well as in vivo malignant cell extravasation from blood vessels and lung metastasis formation. miR-214 has also been found to be highly expressed in human melanomas, and to directly and indirectly regulate several genes involved in tumor progression and in the establishment of dis- tant metastases (Penna et al., 2011). In this work, we exploit a computational pipeline integrating data from multiple online data repositories to identify the presence of transcriptional or post-transcriptional regulatory modules involving miR-214 and a set of 73 previously identified miR-214 regulated genes. We identified 27 putative regulatory modules involving miR-214, NFKB1, SREBPF2, miR-33a and 9 out of the 73 miR-214 modulated genes (ALCAM, POSTN, TFAP2A, ADAM9, NCAM1, SEMA3A, PVRL2, JAG1, EGFR1). As a pre- liminary experimental validation we focused on 9 out of the 27 identified regulatory modules that involve two main players, miR-33a and SREBF2. The results confirm the importance of the predictions obtained with the presented computational approach