Scientific Goals and Instrument Performance of the Gamma-Ray Imaging Detector AGILE

AGILE is a project of the Italian Space Agency (ASI) Scientific Program dedicated to γ-ray astrophysics. It will simultaneously detect and image photons in the 30 MeV – 50 GeV and in the 10–40 keV energy ranges. It is planned to be operational during the second half of 2005 and it will be the only Mission entirely dedicated to γ-ray astrophysics above 30 MeV during the period 2005–2007. We discuss the expected performance of the AGILE space detector, which scientific program emphasizes a quick response to γ-ray transients and multiwavelength studies of γ-ray sources

When challenges hinder: An investigation of buyer-imposed stressors on supplier flexibility

Working with buyers may drive business growth but can also induce supplier stress. Drawing on Job Demands–Resources (JD-R) theory, this study explored how buyer-imposed work stressors affect supplier flexibility. Employing a scenario-based experiment involving 338 managers, we found that the imposition of challenge stressors increases supplier flexibility when hindrance stressors are low. Conversely, when hindrance stressors are high, imposing challenge stressors reduces supplier flexibility. We also found that supplier bricolage negatively moderates the relationship between buyer-imposed challenge stressors and supplier flexibility. Specifically, we confirmed that suppliers with higher bricolage are less willing to provide flexibility in response to challenge stressors. For practitioners, our study not only identified the type of work stressors they should impose on suppliers to boost flexibility but also highlighted bricolage as an important moderating factor

Building subsidiary local responsiveness: (when) does the directionality of intrafirm knowledge transfers matter?

The present study focuses on effects of subsidiary internal knowledge-based activities—knowledge transfer and reverse knowledge transfer—and absorptive capacity on local responsiveness. We also examine whether absorptive capacity, shared values, and psychological safety, representing constituents of the motivation-opportunity-ability model of behavior, moderate relationships of subsidiary internal knowledge-based activities with responsiveness. Based on a sample of 173 Chinese subsidiaries, the results suggest knowledge transfer and absorptive capacity facilitate local responsiveness. Shared values moderates positively and absorptive capacity negatively, the relationship between knowledge transfer and responsiveness. Psychological safety strengthens the link between reverse knowledge transfer and local responsiveness

Classical and Keynesian models of inequality and stagnation

This paper studies two formal models of long run growth with a medium-run distributive cycle, both of which feature causal links from the rise in inequality to a deterioration of long run macroeconomic performance. Both versions feature an endogenous income-capital ratio: one through the Keynesian notion of effective demand, the other building on induced bias in technical change. A key focus of the analysis is on the assumptions necessary in both frameworks to generate policy implications consistent with the observed decline of the labor share, the income-capital ratio, and labor productivity growth during the neoliberal era. Importantly, both theories: (a) provide space for mutually reinforcing pro-labor and pro-growth policies in the long run, although they differ in the mechanisms at play in these processes; (b) imply a potential tradeoff between pro-labor policies and growth on one hand, and long-run employment on the other; (c) are consistent with the evidence on the distributive cycle at business cycle frequency

Intrinsic spectra and energetics of BeppoSAX Gamma-Ray Bursts with known redshifts

We present the main results of a study of spectral and energetics properties of twelve gamma-ray bursts (GRBs) with redshift estimates. All GRBs in our sample were detected by BeppoSAX in a broad energy range (2-700 keV). From the redshift estimates and the good-quality BeppoSAX time-integrated spectra we deduce the main properties of GRBs in their cosmological rest frames. All spectra in our sample are satisfactorily represented by the Band model with no significant soft X-ray excesses or spectral absorptions. We find a positive correlation between the estimated total (isotropic) energies in the 1-10000 keV energy range (E_rad) and redshifts z. Interestingly, more luminous GRBs are characterized also by larger peak energies E_p of their EF(E) spectra. Furthermore, more distant GRBs appear to be systematically harder in the X-ray band compared to GRBs with lower redshifts. We discuss how selection and data truncation effects could bias our results and give possible explanations for the correlations that we found.Comment: 10 pages, 5 figures, accepted for publication in Astronomy & Astrophysic

Female hormone utilisation and risk of hepatocellular carcinoma.

The relationship between female hormone use and primary liver cancer was analysed using data from a case-control study conducted between 1984 and 1992 in Milan on 82 female incident cases with histologically or serologically confirmed hepatocellular carcinoma and 368 controls admitted to hospital for acute non-neoplastic, non-hormone-related diseases. An elevated relative risk (RR) or primary liver cancer was observed in oral contraceptive (OC) users (RR 2.6, for ever versus never users, 95% confidence interval, CI 1.0-7.0). The RR was directly related to duration of use (RR 1.5 for < or = 5 years and 3.9 for > 5 years) and persisted for longer than 10 years after stopping use (RR 4.3%, 95% CI 1.0-18.2). The RR were below unity, although not significantly, for women ever using oestrogen replacement therapy (RR 0.2, 95% CI 0.03-1.5) and female hormones for indications other than contraception and menopausal therapy (RR 0.4, 95% CI 0.1-1.5). The long-lasting, association between risk of hepatocellular carcinoma and OC use has potential implications on a public health scale, since primary liver cancer is a relatively rare disease among young women, but much more common at older ages. This study provides limited but reassuring evidence on the possible relationship between oestrogen replacement treatment and subsequent risk of hepatocellular carcinoma

Oral contraceptives and breast cancer in northern Italy. Final report from a case-control study.

To assess the relation between oral contraceptive (OC) use and breast cancer, we analysed data from a case-control study conducted in Northern Italy between 1983 and 1991 on 2,309 cases below age 60 and 1,928 controls admitted to hospital for acute diseases unrelated to OC use and to any of the known or potential risk factors for breast cancer. OC use was reported by 16% of cases and 14% of controls. The multivariate relative risk (RR) for ever vs never use of combination OC was 1.2 (95% confidence interval (CI) 1.0-1.4). However, there was no trend in risk with duration. The RR was elevated for very short use, but declined to 0.8 (95% CI = 0.5-1.0) for five or more years' use. No noteworthy relationship was found for other major measures of OC use, although RR estimates were above unity for women who had stopped use less than 5 years before (RR = 1.5, 95% CI = 1.1-2.0), started use less than 10 years before (RR = 1.3, 95% CI = 1.0-1.9), started when 25 or more years old (RR = 1.4, 95% CI = 1.1-1.7), or after first birth (RR = 1.2, 95% CI = 1.0-1.5). No interaction was observed between OC use and family history of breast cancer, parity and age at first birth. A separate analysis of 373 cases and 456 control below age 40 showed no association with ever use (RR = 0.9, 95% CI = 0.6-1.2)

X-Ray Emission of Gamma-Ray Bursts

X-ray emission can provide a crucial diagnostic of gamma-ray bursts (GRBs). We calculate the X-ray and gamma-ray spectra of impulsive acceleration episodes related to GRB pulses. We use the synchrotron shock model (SSM) as a basis of our calculations. We show that the current data on soft-to-hard emission ratios of GRB pulse emission are in agreement with the SSM. In particular, GRB pulse emission detected by GINGA is in agreement with the SSM low-energy spectra. We deduce that GINGA detected the majority of bright GRBs detectable by BATSE. These results indicate that the physical environment surrounding the GRB emission site is optically thin to X-ray photon energies. We also calculate emission ratios in the Einstein, ROSAT, SAX and HETE energy bands, and discuss how future information on simultaneous soft/hard GRB emission can contribute in distinguishing different emission models. Two different components of X-ray emission may simultaneously exist in a fraction of GRBs. One component is clearly associated with the individual GRB pulses, and an additional component may be related to the pulse X-ray spectral upturns and/or the precursors/tails occasionally observed. We also show that a meaningful search of GRB-driven X-ray flashes in Andromeda (M31) can be carried out with existing ROSAT data and future SAX Wide Field Camera observations.Comment: 18 pages, 5 figures included as postscript files. Astrophysical Journal, in press, vol. 474 (10 April 1997

From 3,4-dinitrothiophene to nitrocyclopropanes and 1,1'-dinitro-1,1'-bi(cyclopropyl) compounds

Treatment of (E,E)-1,4-diaryl-2,3-dinitro-1,3-butadienes (I) with diazomethane in Et2O or THF represents a facile and high-yielding route to 2,2'-diaryl-1,1'-dinitro-1,1'-bi(cyclopropyl)s. The process exclusively produces diastereomeric mixts. of a chiral d,l pair and a meso form, the relative percentages of which depend on the aryl moiety, consistently with a concerted syn-stereoselective cyclopropanation of each double bond. With 1 mol-equiv of CH2N2, the cyclopropanation can effectively be limited to one double bond of the starting dinitrobutadiene, thus allowing a synthetically useful differentiation between the two originally conjugated nitrovinyl moieties. As verified with model derivs., the resulting vinylcyclopropanes can be cyclopropanated with excess diazomethane to give the same diastereomeric mixts. as obtained by direct bis(cyclopropanation) of I