The cenological paradigm in the designing of the digital twin of the human capital structure

The object of research in this article is the category “human capital” as the foundation for the development of generations and the state in the digital future. This category is directly dependent on the complication of economic systems, changes in the information space and society digitalization. Highlighting of the features of the political and economic nature of “human capital” is possible from the standpoint of its assessment as a key state resource, the impact indicators of which are a combination of classical and newly identified information parameters. In an effort to expand the understanding of the phenomena of institutional changes, of economics and public administration, the multilevel causal model is proposed. The forces of the model act in two directions: macro-causes that explain behaviour at the micro level, and the microlevel laws affecting the entire system at the macrolevel. As a part of the development of interdisciplinary research, the article proposes a new conceptual approach to the formalization and management of the human capital structure. The basis of integration is cenological theory that allows to formalize the system of macro-rules ensuring the stability of complex systems, in particular, of the generations in the information space. The basic research paradigm is proposed and promising results are determined on the example of stratification of human capital parameters

Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage

Brain-derived neurotrophic factor (BDNF) is a classic neuroprotective and pro-regenerative factor in peripheral and central nervous tissue. Its ability to stimulate the restoration of damaged nerve and brain tissue after ischemic stroke and intraventricular hemorrhage has been demonstrated. However, the current concept of regeneration allows us to assert that one factor, even if essential, cannot be the sole contributor to this complex biological process. We have previously shown that urokinase-type plasminogen activator (uPA) complements BDNF activity and stimulates restoration of nervous tissue. Using a model of intracerebral hemorrhage in rats, we investigated the neurotrophic and neuroprotective effect of BDNF combined with uPA. The local simultaneous administration of BDNF and uPA provided effective neuroprotection of brain tissue after intracerebral hemorrhage, promoted survival of experimental animals and their neurological recovery, and decreased lesion volume. The study of cellular mechanisms of the observed neurotrophic effect of BDNF and uPA combination revealed both known mechanisms (neuronal survival and neurite growth) and new ones (microglial activation) that had not been shown for BDNF and uPA. Our findings support the concept of using combinations of biological factors with diverse but complementary mechanisms of action as a promising regenerative approach