Modelling gravity on a hyper-cubic lattice

We present an elegant and simple dynamical model of symmetric, non-degenerate (n x n) matrices of fixed signature defined on a n-dimensional hyper-cubic lattice with nearest-neighbor interactions. We show how this model is related to General Relativity, and discuss multiple ways in which it can be useful for studying gravity, both classical and quantum. In particular, we show that the dynamics of the model when all matrices are close to the identity corresponds exactly to a finite-difference discretization of weak-field gravity in harmonic gauge. We also show that the action which defines the full dynamics of the model corresponds to the Einstein-Hilbert action to leading order in the lattice spacing, and use this observation to define a lattice analogue of the Ricci scalar and Einstein tensor. Finally, we perform a mean-field analysis of the statistical mechanics of this model.Comment: 5 page

Generalized Classical BRST Cohomology and Reduction of Poisson Manifolds

In this paper, we formulate a generalization of the classical BRST construction which applies to the case of the reduction of a poisson manifold by a submanifold. In the case of symplectic reduction, our procedure generalizes the usual classical BRST construction which only applies to symplectic reduction of a symplectic manifold by a coisotropic submanifold, \ie\ the case of reducible ``first class'' constraints. In particular, our procedure yields a method to deal with ``second-class'' constraints. We construct the BRST complex and compute its cohomology. BRST cohomology vanishes for negative dimension and is isomorphic as a poisson algebra to the algebra of smooth functions on the reduced poisson manifold in zero dimension. We then show that in the general case of reduction of poisson manifolds, BRST cohomology cannot be identified with the cohomology of vertical differential forms.Comment: 3

Wheat pathogen Zymoseptoria tritici N-myristoyltransferase inhibitors: on-target antifungal activity and an unusual metabolic defense mechanism

Zymoseptoria tritici is the causative agent of Septoria tritici blotch (STB), which costs billions of dollars annually to major wheat-producing countries in terms of both fungicide use and crop loss. Agricultural pathogenic fungi have acquired resistance to most commercially available fungicide classes, and the rate of discovery and development of new fungicides has stalled, demanding new approaches and insights. Here we investigate a potential mechanism of targeting an important wheat pathogen Z. tritici via inhibition of N-myristoyltransferase (NMT). We characterize Z. tritici NMT biochemically for the first time, profile the in vivo Z. tritici myristoylated proteome and identify and validate the first Z. tritici NMT inhibitors. Proteomic investigation of the downstream effects of NMT inhibition identified an unusual and novel mechanism of defense against chemical toxicity in Z. tritici through the application of comparative bioinformatics to deconvolute function from the previously largely unannotated Z. tritici proteome. Research into novel fungicidal modes-of-action is essential to satisfy an urgent unmet need for novel fungicide targets, and we anticipate that this study will serve as a useful proteomics and bioinformatics resource for researchers studying Z. tritici

Transient absorption and reshaping of ultrafast XUV light by laser-dressed helium

We present a theoretical study of transient absorption and reshaping of extreme ultraviolet (XUV) pulses by helium atoms dressed with a moderately strong infrared (IR) laser field. We formulate the atomic response using both the frequency-dependent absorption cross section and a time-frequency approach based on the time-dependent dipole induced by the light fields. The latter approach can be used in cases when an ultrafast dressing pulse induces transient effects, and/or when the atom exchanges energy with multiple frequency components of the XUV field. We first characterize the dressed atom response by calculating the frequency-dependent absorption cross section for XUV energies between 20 and 24 eV for several dressing wavelengths between 400 and 2000 nm and intensities up to 10^12 W/cm^2. We find that for dressing wavelengths near 1600 nm, there is an Autler-Townes splitting of the 1s ---> 2p transition that can potentially lead to transparency for absorption of XUV light tuned to this transition. We study the effect of this XUV transparency in a macroscopic helium gas by incorporating the time-frequency approach into a solution of the coupled Maxwell-Schr\"odinger equations. We find rich temporal reshaping dynamics when a 61 fs XUV pulse resonant with the 1s ---> 2p transition propagates through a helium gas dressed by an 11 fs, 1600 nm laser pulse.Comment: 13 pages, 8 figures, 1 table, RevTeX4, revise

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes

OBJECTIVE—Previous work has demonstrated that chronic administration of the serotonin reuptake inhibitor (SSRI) fluoxetine augments counterregulatory responses to hypoglycemia in healthy humans. However, virtually no information exists regarding the effects of fluoxetine on integrated physiological counterregulatory responses during hypoglycemia in type 1 diabetes. Therefore, the specific aim of this study was to test the hypothesis that 6-week use of the SSRI fluoxetine would amplify autonomic nervous system (ANS) counterregulatory responses to hypoglycemia in individuals with type 1 diabetes

The Anatomy of Memory Politics: A Formalist Analysis of Tate Britain’s ‘Artist and Empire’ and the Struggle over Britain’s Imperial Past

In this paper, I propose a new approach for understanding the meaning of memory politics, which draws upon the archetypal literary criticism of Northrop Frye. I suggest that the four archetypes elaborated by Frye—comedy, romance, tragedy, and satire—can be used as a heuristic device for interpreting the contested historical narratives that are associated with the politics of memory. I illustrate this approach through a case-study of Artists and Empire: Facing Britain’s Imperial Past, an exhibition held at Tate Britain in 2016, amidst increasing contestation over the meaning of the British Empire. In sum, I find that the exhibit narrated Britain’s imperial past as a comedy, in which a key theme was the progressive cultural mixing of the British and the people they colonized. To conclude, I discuss the implications of such a narrative for constructing an inclusive, postcolonial British identity. As an alternative, I draw on Aristotle to suggest that a tragic narrative would have been more propitious

Global Health and Disability: A Review and Call to Action for All Rehabilitation Professions

The World Health Organization estimates 15% of the world’s population is living with disability and anticipates an increase as the population ages. Disability is a growing healthcare concern and presents a tremendous burden to all nations. The world will soon need to provide health and rehabilitative care for an enormous number of persons with disability. The purpose of this article is to provide a brief narrative review pertaining to global health and rehabilitation, and to motivate the rehabilitation professions in taking immediate action through further investment in global health initiatives to manage both the current and projected burden of disability. A deficient level of research exists in global health by the rehabilitation professions and there is significant lag in their efforts when compared to other healthcare professions. The World Health Organization’s World Report on Disability (2011), Global Disability Action Plan 2014-2021, and the Global Burden of Disease study are pivotal bodies of work in this field. They serve as both a model and a challenge to affect large-scale global change among the rehabilitation professions. Collectively, an immediate effort is needed to bolster disability and rehabilitation research in developing nations, global rehabilitative outreach programs, and improve access to rehabilitative healthcare to persons with disability in order to fully address the magnitude of this matter

Modelling Nitrous Oxide Emissions from Grazed Grasslands in New Zealand

Spatial and temporal variability are major difficulties when quantifying annual N2O fluxes at the field scale. New Zealand currently relies on the IPCC default methodology (National Inventory Report, 2004). This methodology is too simplistic and generalised as it ignores all site-specific controls, but is also not sufficiently flexible to allow mitigation options to be assessed. Therefore, a more robust, process-based approach is required to quantify N2O emissions more accurately at the field level. Denitrification-decomposition (DNDC) is a process-based model originally developed (Li et al., 1992) to quantify agricultural nitrous oxide (N2O) emissions across climatic zones, soil types, and management regimes. This has been modified to represent New Zealand grazed grassland systems (Saggar et al., 2004). More recent modifications include measured biomass C and N parameters in perennial pasture and compaction impacts on the soil water dynamics. Further validation tests have been conducted against observed soil moisture and gas fluxes. Here we i) assess the ability of a modified DNDC model NZ-DNDC to simulate N2O emissions; ii) compare the measured, modelled and IPCCestimated N2O emissions from dairy- and sheep-grazed pastures; and iii) give preliminary results for upscaling the model to provide preliminary regional emissions estimates

Aeroplastic, New Composite Materials with Reduced Heat Transfer and Increased Flame Retardancy

A new composite system formulated using commodity grade and engineered grade polymers. The composites can be fabricated into fibers, molded, or otherwise processed into useable articles. Use of this technology reduces the thermal conductivity and peak heat releases rates of the base polymer between 20%-50% while maintaining or enhancing the mechanical properties.

Wastewater discharge at casey Station, Antarctica. December 1999.

Over the summer period December 1997/January 1998, a program of field work was undertaken as part of a research project to develop numerical models of the wastewater discharge systems entering the marine waters off Casey Station in Antarctica. Samples were evaluated for ammonia, total phosphorus, and four categories of bacteria of the study period , and levels compared with the wastewater treatment plant influent and effluent, and marine background levels. Elevated levels of all parameters measured were found in the vicinity of the discharge, an area frequented by penguins from the nearby rookery. Dilution factors were calculated for esch of the three parameters and range from 4 for phosphorus to 600 for bacteria. The study also found that levels of the three measured parameters increased as the air temperature increased due to accelerated melting of the snow and ice through which the wastewater flows before entering the marine environment