Introducing Latent Timbre Synthesis

We present the Latent Timbre Synthesis (LTS), a new audio synthesis method using Deep Learning. The synthesis method allows composers and sound designers to interpolate and extrapolate between the timbre of multiple sounds using the latent space of audio frames. We provide the details of two Variational Autoencoder architectures for LTS, and compare their advantages and drawbacks. The implementation includes a fully working application with graphical user interface, called \textit{interpolate\_two}, which enables practitioners to explore the timbre between two audio excerpts of their selection using interpolation and extrapolation in the latent space of audio frames. Our implementation is open-source, and we aim to improve the accessibility of this technology by providing a guide for users with any technical background

Koszul-Tate Cohomology For an Sp(2)-Covariant Quantization of Gauge Theories with Linearly Dependent Generators

The anti-BRST transformation, in its Sp(2)-symmetric version, for the general case of any stage-reducible gauge theories is implemented in the usual BV approach. This task is accomplished not by duplicating the gauge symmetries but rather by duplicating all fields and antifields of the theory and by imposing the acyclicity of the Koszul-Tate differential. In this way the Sp(2)-covariant quantization can be realised in the standard BV approach and its equivalence with BLT quantization can be proven by a special gauge fixing procedure.Comment: 13 pages, Latex, To Be Published in International Journal of Modern Physics

Knot invariants and M-theory: Hitchin equations, Chern-Simons actions, and surface operators

Recently Witten introduced a type IIB brane construction with certain boundary conditions to study knot invariants and Khovanov homology. The essential ingredients used in his work are the topologically twisted N = 4 Yang-Mills theory, localization equations and surface operators. In this paper we extend his construction in two possible ways. On one hand we show that a slight modification of Witten's brane construction could lead, using certain well defined duality transformations, to the model used by Ooguri-Vafa to study knot invariants using gravity duals. On the other hand, we argue that both these constructions, of Witten and of Ooguri-Vafa, lead to two different seven-dimensional manifolds in M-theory from where the topological theories may appear from certain twisting of the G-flux action. The non-abelian nature of the topological action may also be studied if we take the wrapped M2-brane states in the theory. We discuss explicit constructions of the seven-dimensional manifolds in M-theory, and show that both the localization equations and surface operators appear naturally from the Hamiltonian formalism of the theories. Knots and link invariants are then constructed using M2-brane states in both the models.Comment: 153 pages, 15 pdf figures, LaTex. v2: Minor corrections to section 2.2; v3: Some typos corrected, references updated and a new section added. Final version to appear in Physical Review

The evolution of bits and bottlenecks in a scientific workflow trying to keep up with technology: Accelerating 4D image segmentation applied to nasa data

In 2016, a team of earth scientists directly engaged a team of computer scientists to identify cyberinfrastructure (CI) approaches that would speed up an earth science workflow. This paper describes the evolution of that workflow as the two teams bridged CI and an image segmentation algorithm to do large scale earth science research. The Pacific Research Platform (PRP) and The Cognitive Hardware and Software Ecosystem Community Infrastructure (CHASE-CI) resources were used to significantly decreased the earth science workflow's wall-clock time from 19.5 days to 53 minutes. The improvement in wall-clock time comes from the use of network appliances, improved image segmentation, deployment of a containerized workflow, and the increase in CI experience and training for the earth scientists. This paper presents a description of the evolving innovations used to improve the workflow, bottlenecks identified within each workflow version, and improvements made within each version of the workflow, over a three-year time period

GUT theories from Calabi-Yau 4-folds with SO(10) Singularities

We consider an SO(10) GUT model from F-theory compactified on an elliptically fibered Calabi-Yau with a D5 singularity. To obtain the matter curves and the Yukawa couplings, we use a global description to resolve the singularity. We identify the vector and spinor matter representations and their Yukawa couplings and we explicitly build the G-fluxes in the global model and check the agreement with the semi-local results. As our bundle is of type SU(2k), some extra conditions need to be applied to match the fluxes.Comment: 27 page

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.

Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons). Here, we examined Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with β-gal and neo cassettes. Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferation, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect. In addition, Slurp1(-/-) mice exhibited reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and a neuromuscular abnormality (hind-limb clasping). Initially, it was unclear whether the metabolic and neuromuscular phenotypes were due to Slurp1 deficiency, because we found that the targeted Slurp1 mutation reduced the expression of several neighboring genes (e.g., Slurp2, Lypd2). We therefore created a new line of knockout mice (Slurp1X(-/-) mice) with a simple nonsense mutation in exon 2. The Slurp1X mutation did not reduce the expression of adjacent genes, but Slurp1X(-/-) mice exhibited all of the phenotypes observed in the original line of knockout mice. Thus, Slurp1 deficiency in mice elicits metabolic and neuromuscular abnormalities in addition to PPK

A shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans

Small molecule metabolites play important roles in Caenorhabditis elegans biology, but effective approaches for identifying their chemical structures are lacking. Recent studies revealed that a family of glycosides, the ascarosides, differentially regulate C. elegans development and behavior. Low concentrations of ascarosides attract males and thus appear to be part of the C. elegans sex pheromone, whereas higher concentrations induce developmental arrest at the dauer stage, an alternative, nonaging larval stage. The ascarosides act synergistically, which presented challenges for their identification via traditional activity-guided fractionation. As a result the chemical characterization of the dauer and male attracting pheromones remained incomplete. Here, we describe the identification of several additional pheromone components by using a recently developed NMR-spectroscopic approach, differential analysis by 2D NMR spectroscopy (DANS), which simplifies linking small molecule metabolites with their biological function. DANS-based comparison of wild-type C. elegans and a signaling-deficient mutant, daf-22, enabled identification of 3 known and 4 previously undescribed ascarosides, including a compound that features a p-aminobenzoic acid subunit. Biological testing of synthetic samples of these compounds revealed additional evidence for synergy and provided insights into structure–activity relationships. Using a combination of the three most active ascarosides allowed full reconstitution of the male-attracting activity of wild-type pheromone extract. Our results highlight the efficacy of DANS as a method for identifying small-molecule metabolites and placing them within a specific genetic context. This study further supports the hypothesis that ascarosides represent a structurally diverse set of nematode signaling molecules regulating major life history traits

Chiral field theories from conifolds

We discuss the geometric engineering and large n transition for an N=1 U(n) chiral gauge theory with one adjoint, one conjugate symmetric, one antisymmetric and eight fundamental chiral multiplets. Our IIB realization involves an orientifold of a non-compact Calabi-Yau A_2 fibration, together with D5-branes wrapping the exceptional curves of its resolution as well as the orientifold fixed locus. We give a detailed discussion of this background and of its relation to the Hanany-Witten realization of the same theory. In particular, we argue that the T-duality relating the two constructions maps the Z_2 orientifold of the Hanany-Witten realization into a Z_4 orientifold in type IIB. We also discuss the related engineering of theories with SO/Sp gauge groups and symmetric or antisymmetric matter.Comment: 34 pages, 8 figures, v2: References added, minor correction

Non Equilibrium Electronic Distribution in Single Electron Devices

The electronic distribution in devices with sufficiently small diemnsions may not be in thermal equilibrium with their surroundings. Systems where the occupancies of electronic states are solely determined by tunneling processes are analyzed. It is shown that the effective temperature of the device may be higher, or lower, than that of its environment, depending on the applied voltage and the energy dependence of the tunneling rates. The I-V characteristics become asymmetric. Comparison with recent experiments is made