522 research outputs found
Workshop on manpower development and training in toxicology and chemical safety. Luxembourg, 28 November - 2 December 1983. Industrial health and safety. EUR 9619 EN
Correlated patterns in non-monotonic graded-response perceptrons
The optimal capacity of graded-response perceptrons storing biased and
spatially correlated patterns with non-monotonic input-output relations is
studied. It is shown that only the structure of the output patterns is
important for the overall performance of the perceptrons.Comment: 4 pages, 4 figure
A toy model of the five-dimensional universe with the cosmological constant
A value of the cosmological constant in a toy model of the five-dimensional
universe is calculated in such a manner that it remains in agreement with both
astronomical observations and the quantum field theory concerning the
zero-point fluctuations of the vacuum. The (negative) cosmological constant is
equal to the inverse of the Planck length squared, which means that in the toy
model the vanishing of the observed value of the cosmological constant is a
consequence of the existence of an energy cutoff exactly at the level of the
Planck scale. In turn, a model for both a virtual and a real
particle-antiparticle pair is proposed which describes properly some energetic
properties of both the vacuum fluctuations and created particles, as well as it
allows one to calculate the discrete "bare" values of an elementary-particle
mass, electric charge and intrinsic angular momentum (spin) at the energy
cutoff. The relationships between the discussed model and some phenomena such
as the Zitterbewegung and the Unruh-Davies effect are briefly analyzed, too.
The proposed model also allows one to derive the Lorentz transformation and the
Maxwell equations while considering the properties of the vacuum filled with
the sea of virtual particles and their antiparticles. Finally, the existence of
a finite value of the vacuum-energy density resulting from the toy model leads
us to the formulation of dimensionless Einstein field equations which can be
derived from the Lagrangian with a dimensionless (naively renormalized)
coupling constant.Comment: 52 pages, 1 figure; a post-final, rewritten version with a number of
new remarks and conclusion
Generalizing with perceptrons in case of structured phase- and pattern-spaces
We investigate the influence of different kinds of structure on the learning
behaviour of a perceptron performing a classification task defined by a teacher
rule. The underlying pattern distribution is permitted to have spatial
correlations. The prior distribution for the teacher coupling vectors itself is
assumed to be nonuniform. Thus classification tasks of quite different
difficulty are included. As learning algorithms we discuss Hebbian learning,
Gibbs learning, and Bayesian learning with different priors, using methods from
statistics and the replica formalism. We find that the Hebb rule is quite
sensitive to the structure of the actual learning problem, failing
asymptotically in most cases. Contrarily, the behaviour of the more
sophisticated methods of Gibbs and Bayes learning is influenced by the spatial
correlations only in an intermediate regime of , where
specifies the size of the training set. Concerning the Bayesian case we show,
how enhanced prior knowledge improves the performance.Comment: LaTeX, 32 pages with eps-figs, accepted by J Phys
Milestones and Impact Factors
Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within the biomedical field. During the past eight years, Open Access journals have become widely available, although still covering only about 15% of journal titles. Major funding agencies and institutions, including prominent US universities, now require that researchers publish in Open Access journals. Because of the profound role of scientific journals for the sharing of results and communication between researchers, the advent of Open Access may be of as much significance as the transition from handwriting to printing via moveable type. As Environmental Health is an electronic Open Access journal, the numbers of downloads at the journal website can be retrieved. The top-20 list of articles most frequently accessed shows that all of them have been downloaded over 10,000 times. Back in 2002, the first article published was accessed only 49 times during the following month. A year later, the server had over 1,000 downloads per month, and now the total number of monthly downloads approaches 50,000. These statistics complement the Impact Factor and confirm the viability of Open Access in our field of research. The advent of digital media and its decentralized mode of distribution - the internet - have dramatically changed the control and financing of scientific information dissemination, while facilitating peer review, accelerating editorial handling, and supporting much needed transparency. Both the meaning and means of "having an impact" are therefore changing, as will the degree and way in which scientific journals remain "factors" in that impact
Occupational asthma caused by cobalt chloride in a diamond polisher after cessation of occupational exposure: a case report
Objectives: The inspiration of cobalt containing dust leads to various respiratory symptoms, including asthma and interstitial lung disease. Occupational asthma caused by cobalt chloride has been diagnosed in a 35-year-old patient, who worked as a diamond polishing disc former. The patient presented a 2-year history of dyspnea, cough and symptoms of rhinitis. Materials and Methods: The patient underwent a medical history interview, skin prick tests with common and occupational allergens (cobalt and nickel chloride), and pulmonary function testing both before and after the nasal provocation with 0.05% cobalt chloride. Additionally, the authors analyzed morphological and biochemical changes before and after the specific nasal challenge test. Cell proliferation analysis was also carried out. Results: Skin prick tests (SPTs) with common environmental allergens were found to be negative, while SPTs with cobalt chloride were positive for all applied solutions. The provocation with cobalt chloride caused a significant increase in the proportion of eosinophils, basophils and albumin during the late allergic reaction. The positive lymphocyte transformation caused by cobalt was also observed. Conclusions: Cobalt salts may induce occupational asthma. The mechanism of this asthma may be IgE-mediated. The cobalt-sensitized lymphocytes may play an important role in this disease
Activating Killer Immunoglobulin Receptors and HLA-C: A successful combination providing HIV-1 control
Several studies demonstrated a relevant role of polymorphisms located within the HLA-B and -C loci and the Killer Immunoglobulin Receptors (KIRs) 3DL1 and 3DS1 in controlling HIV-1 replication. KIRs are regulatory receptors expressed at the surface of NK and CD8+ T-cells that specifically bind HLA-A and -B alleles belonging to the Bw4 supratype and all the -C alleles expressing the C1 or C2 supratype. We here disclose a novel signature associated with the Elite Controller but not with the long-term nonprogressor status concerning 2DS activating KIRs and HLA-C2 alleles insensitive to miRNA148a regulation. Overall, our findings support a crucial role of NK cells in the control of HIV-1 viremia
Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization
Directional transport of the phytohormone auxin is a versatile, plant-specific mechanism regulating many aspects of plant development. The recently identified plant hormones, strigolactones (SLs), are implicated in many plant traits; among others, they modify the phenotypic output of PIN-FORMED (PIN) auxin transporters for fine-tuning of growth and developmental responses. Here, we show in pea and Arabidopsis that SLs target processes dependent on the canalization of auxin flow, which involves auxin feedback on PIN subcellular distribution. D14 receptor- and MAX2 F-box-mediated SL signaling inhibits the formation of auxin-conducting channels after wounding or from artificial auxin sources, during vasculature de novo formation and regeneration. At the cellular level, SLs interfere with auxin effects on PIN polar targeting, constitutive PIN trafficking as well as clathrin-mediated endocytosis. Our results identify a non-transcriptional mechanism of SL action, uncoupling auxin feedback on PIN polarity and trafficking, thereby regulating vascular tissue formation and regeneration
Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's disease
<p>Abstract</p> <p>Background</p> <p>Recent clinical studies point to rapid and sustained clinical, cognitive, and behavioral improvement in both Alzheimer's disease and primary progressive aphasia following weekly perispinal administration of etanercept, a TNF-alpha inhibitor that acts by blocking the binding of this cytokine to its receptors. This outcome is concordant with recent basic science studies suggesting that TNF-alpha functions <it>in vivo </it>as a gliotransmitter that regulates synaptic function in the brain. We hypothesized that perispinal etanercept had the potential to improve verbal function in Alzheimer's disease, so we included several standarized measures of verbal ability to evaluate language skills in a clinical trial of perispinal etanercept for Alzheimer's disease.</p> <p>Methods</p> <p>This was a prospective, single-center, open-label, pilot study, in which 12 patients with mild-to-severe Alzheimer's disease were administered etanercept, 25–50 mg, weekly by perispinal administration for six months. Two additional case studies are presented.</p> <p>Results</p> <p>Two-tailed, paired t-tests were conducted comparing baseline performance to 6-month performance on all neuropsychological measures. Test batteries included the California Verbal Learning Test-Second Edition, Adult Version; Logical Memory I and II(WMS-LM-II) from the Wechsler Memory Scale-Abbreviated; the Comprehensive Trail Making Test (TMT); Boston Naming Test; and letter(FAS) and category verbal fluency. All measures revealed a significant effect except for the Boston Naming Test and the TMT-4, with WMS-LM-II being marginally significant at p = .05. The FAS test for letter fluency was most highly significant with a p < 0.0007. In addition, rapid improvement in verbal fluency and aphasia in two patients with dementia, beginning minutes after perispinal etanercept administration, is documented.</p> <p>Conclusion</p> <p>In combination with the previously reported results of perispinal etanercept in Alzheimer's disease and primary progressive aphasia, these results further argue that larger scale studies of this therapeutic intervention, including Phase 3 trials, are warranted in dementias. In addition, these results may provide insight into the basic pathophysiologic mechanisms underlying Alzheimer's disease and related forms of dementia, and suggest the existence of novel, rapidly reversible, TNF-mediated pathophysiologic mechanisms in Alzheimer's disease which are worthy of further investigation.</p
Interleukin-10 may protect against progressing injury during the acute phase of ischemic stroke
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