Antiangiogenic Effect of Chamigrane Endoperoxides from a Thai Mangrove-Derived Fungus

As part of our ongoing efforts to investigate natural products with potential for use as cancer treatments, we have recently disclosed the cytotoxicity of unique nor-chamigrane (<b>1</b>) and chamigrane (<b>2</b>, <b>3</b>) endoperoxides from a Thai mangrove-derived fungus. Reinvestigation of this fungus in a large-scale fermentation led to the isolation of an additional new chamigrane endoperoxide (<b>4</b>) and one known analogue (<b>5</b>). Among these isolated metabolites, compound <b>3</b> (merulin C) exhibited potent antiangiogenic activity mainly by suppression of endothelial cell proliferation and migration in a dose-dependent manner, and its effect is mediated by reduction in the phosphorylation of Erk1/2. Merulin C also displayed promising activity in a rat aortic ring sprouting (ex vivo) and a mouse Matrigel (in vivo) assay

Salicylaldehyde and dihydroisobenzofuran derivatives from the marine fungus <i>Zopfiella marina</i>

<p>Two salicylaldehyde derivatives (<b>1</b> and <b>2</b>), a hydroxymethylphenol (<b>3</b>), five dihydroisobenzofuran (<b>4</b>–<b>8</b>) derivatives, and a 5-chloro-3-deoxyisoochracinic acid (<b>9</b>), together with a known 3-deoxyisoochracinic acid (<b>10</b>) were isolated from the marine fungus <i>Zopfiella marina</i> BCC 18240 (or NBRC 30420). The structures of these compounds were elucidated by extensive spectroscopic analysis. Compound <b>1</b> showed weak antituberculous activity against <i>Mycobacterium tuberculosis</i> H37Ra, and antibacterial activity against <i>Bacillus cereus</i> with MIC values of 25 and 12.5 μg/mL, respectively.</p