10,10-Bis(dimethylamino)nonafulvene

Li-, K- and [(CH₃)₄N] cyclononatetraenides (1)[¹] are the only monocyclic derivatives of the hypothetical cyclononatetraene that have been isolated so far[²]

10,10-Bis(dimethylamino)nonafulven

Mit Ausnahme des Li-, K- und [(CH3)4N]-Cyclononatetraenids (1) [¹] wurden bisher keine monocyclischen Derivate des hypothetischen Cyclononatetraens isoliert [²]

Properties of Protostars in the Elephant Trunk in the Globule IC 1396A

Extremely red objects, identified in the early Spitzer Space Telescope observations of the bright-rimmed globule IC 1396A and photometrically classified as Class I protostars and Class II T Tauri stars based on their mid-infrared (mid-IR) colors, were spectroscopically observed at 5.5-38 μm (Spitzer Infrared Spectrograph), at the 22 GHz water maser frequency (National Radio Astronomy Observatory Green Bank Telescope), and in the optical (Palomar Hale 5 m) to confirm their nature and further elucidate their properties. The sources photometrically identified as Class I, including IC 1396A:α, γ, δ, ε, and ζ, are confirmed as objects dominated by accretion luminosity from dense envelopes, with accretion rates 1-10 × 10^–6 M☉ yr^–1 and present stellar masses 0.1-2 M☉. The Class I sources have extremely red continua, still rising at 38 μm, with a deep silicate absorption at 9-11 μm, weaker silicate absorption around 18 μm, and weak ice features including CO2 at 15.2 μm and H2O at 6 μm. The ice/silicate absorption ratio in the envelope is exceptionally low for the IC 1396A protostars, compared to those in nearby star-forming regions, suggesting that the envelope chemistry is altered by the radiation field or globule pressure. Only one 22 GHz water maser was detected in IC 1396A; it is coincident with a faint mid-IR source, offset from near the luminous Class I protostar IC 1396A:γ. The maser source, IC 1396A:γb, has luminosity less than 0.1 L☉, the first H2O maser from such a low-luminosity object. Two near-infrared (NIR) H2 knots on opposite sides of IC 1396A:γ reveal a jet, with an axis clearly distinct from the H2O maser of IC 1396A:γb. The objects photometrically classified as Class II, including IC 1396A:β, θ, Two Micron All Sky Survey (2MASS)J 21364964+5722270, 2MASSJ 21362507+5727502, LkHα 349c, Tr 37 11-2146, and Tr 37 11-2037, are confirmed as stars with warm, luminous disks, with a silicate emission feature at 9-11 μm, and bright Hα emission; therefore, they are young, disk-bearing, classical T Tauri stars. The disk properties change significantly with source luminosity: low-mass (G-K) stars have prominent 9-11 emission features due to amorphous silicates while higher-mass (A-F) stars have weaker features requiring abundant crystalline silicates. A mineralogical model that fits the wide- and low-amplitude silicate feature of IC 1396A:θ requires small grains of crystalline olivine (11.3 μm peak) and another material to to explain its 9.1 μm peak; reasonable fits are obtained with a phyllosilicate, quartz, or relatively large (greater than 10 μm) amorphous olivine grains. The distribution of Class I sources is concentrated within the molecular globule, while the Class II sources are more widely scattered. Combined with the spectral results, this suggests two phases of star formation, the first (4 Myr ago) leading to the widespread Class II sources and the central O star of IC 1396 and the second (less than 1 Myr ago) occurring within the globule. The recent phase was likely triggered by the wind and radiation of the central O star of the IC 1396 H II region

The Paleoarchean Buffalo River komatiites: Progressive melting of a single large mantle plume beneath the growing Kaapvaal craton

Several Archean granitoid-greenstone terranes are exposed on the southeastern Kaapvaal craton in South Africa, but they received little scientific attention compared to the archetypal greenstone belt successions of the Barberton Mountain Land at the eastern craton margin. This study reports on a detailed field and geochemical survey of the Buffalo River Greenstone Belt at the southern Kaapvaal craton margin in KwaZulu-Natal, with focus on hitherto unstudied komatiites and basaltic rocks from this volcanic succession. Cross-cutting relationships and new U-Pb zircon age determinations for several granitoid units establish a minimum age of 3.26 Ga for komatiitic volcanism, possibly as old as ca. 3.5 Ga if a 3.47 Ga granodiorite sheet is interpreted as ‘intrusive’ into the greenstone succession. Geochemical data reveal three types of Paleoarchean komatiites at Buffalo River. Spinifex textured lava flows represent Al-depleted komatiites, with subchondritic Al2O3/TiO2 ratios and enrichment of LREE over HREE. The second type comprises Al-undepleted komatiites that have chondritic Al2O3/TiO2 and flat REE patterns. The third type identified comprises Al-enriched komatiites that display suprachondritic Al2O3/TiO2 ratios, with significant LREE depletion. The Al-depleted and Al-undepleted komatiites from Buffalo River are geochemically similar to komatiites from the 3.48 Ga Komati and 3.26 Ga Weltevreden formations of the Barberton Supergroup respectively, whereas the Al-enriched komatiites resemble the 3.33 Ga Commondale komatiites on the southeastern Kaapvaal craton. To explain the co-occurrence of three discrete komatiite types within a single volcanic succession at Buffalo River, we suggest that each major komatiite magmatic pulse originated from the same upwelling mantle source, from which melt was extracted at different pressure but similarly hot temperature conditions. 187Os/188Os data for the Al-depleted komatiites suggest an ultimate magma origin from a primitive mantle reservoir. The contrasting γOs values for Kaapvaal craton komatiites (zero to positive) and peridotitic mantle xenoliths (zero to negative) support a complementary nature of these lithologies as high-degree melts and depleted residues linked by vigorous mantle plume activity at around 3.5 Ga. Such a relationship can explain the contrasting Re/Os systematics of komatiites and lithospheric mantle peridotites, which creates the contrasting γOs over time. The highly siderophile element patterns of the Al-depleted komatiites from Buffalo River are similar to those of Barberton-type komatiites, for which an origin from the deepest upper mantle with high melt retention in an upwelling plume source was suggested. We confirm that this ca. 3.5 Ga mantle source had only 60–80 % of the platinum-group element budget of the modern ambient mantle, which points indirectly to a location at great depth in the aftermath of the meteoritic late accretion. Progressive melting of such an upwelling mantle source, to the point of majoritic garnet exhaustion, may explain the Al-undepleted and Al-enriched komatiites at Buffalo River. The presence of all three major komatiite types within a single volcanic succession may be linked to deep critical melting of a large mantle plume associated with growth of the Kaapvaal ‘continent’ at 3.5 Ga

Discovery of superthermal hydroxyl (OH) in the HH211 outflow

We present a 5-37 micron infrared spectrum obtained with the Spitzer Space Telescope toward the southeastern lobe of the young protostellar outflow HH211. The spectrum shows an extraordinary sequence of OH emission lines arising in highly excited rotational levels up to an energy E/k~28200K above the ground level. This is, to our knowledge, by far the highest rotational excitation of OH observed outside Earth. The spectrum also contains several pure rotational transitions of H2O (v=0), H2 (v=0) S(0) to S(7), HD (v=0) R(3) to R(6), and atomic fine-structure lines of [Fe II], [Si II], [Ne II], [S I], and [Cl I]. The origin of the highly excited OH emission is most likely the photodissociation of H2O by the UV radiation generated in the terminal outflow shock of HH211.Comment: ApJ Letters, in pres

El reciclaje de medios de almacenamiento de datos ópticos

Se plantea como opción de reciclaje los discos compactos,  como fuente de materia prima para plásticos de ingeniería de alta calidad. Sin embargo, se mencionó que por razones ecológicas y económicas este objetivo solo se puede alcanzar en la práctica con altos flujos volumétricos de artículos de desecho y residuos industriales, y con el desarrollo de una tecnología de reciclaje diseñada especialmente

Freshly Formed Dust in the Cassiopeia A Supernova Remnant as Revealed by the Spitzer Space Telescope

We performed Spitzer Infrared Spectrograph mapping observations covering nearly the entire extent of the Cassiopeia A supernova remnant (SNR), producing mid-infrared (5.5-35 micron) spectra every 5-10". Gas lines of Ar, Ne, O, Si, S and Fe, and dust continua were strong for most positions. We identify three distinct ejecta dust populations based on their continuum shapes. The dominant dust continuum shape exhibits a strong peak at 21 micron. A line-free map of 21 micron-peak dust made from the 19-23 micron range closely resembles the [Ar II], [O IV], and [Ne II] ejecta-line maps implying that dust is freshly formed in the ejecta. Spectral fitting implies the presence of SiO2, Mg protosilicates, and FeO grains in these regions. The second dust type exhibits a rising continuum up to 21 micron and then flattens thereafter. This ``weak 21 micron'' dust is likely composed of Al2O3 and C grains. The third dust continuum shape is featureless with a gently rising spectrum and is likely composed of MgSiO3 and either Al2O3 or Fe grains. Using the least massive composition for each of the three dust classes yields a total mass of 0.02 Msun. Using the most-massive composition yields a total mass of 0.054 Msun. The primary uncertainty in the total dust mass stems from the selection of the dust composition necessary for fitting the featureless dust as well as 70 micron flux. The freshly formed dust mass derived from Cas A is sufficient from SNe to explain the lower limit on the dust masses in high redshift galaxies.Comment: 8 figures: Accepted for the publication in Ap

The rainbow cohort: 96 week follow-up of saquinavir-containing regimens in previously antiretroviral therapy (ART)-naïve and pre-treated but protease inhibitor (PI)- naïve hiv-infected patients

<p>Abstract</p> <p>Objective</p> <p>We have previously reported data from the German cohort of the multinational observational prospective RAINBOW survey which assessed the tolerability and efficacy of ritonavir-boosted saquinavir (SQV/r)-containing regimens over 48 weeks in routine clinical practice. This analysis presents data from antiretroviral (ART)-naïve and pretreated but protease inhibitor (PI)-naïve patients treated in a long-term one line (96 weeks) follow-up of the initial study.</p> <p>Methods</p> <p>All ART-and PI-naïve patients from the initial RAINBOW cohort who had recorded data to one line 96 weeks of treatment were eligible for inclusion in the current analysis. Efficacy assessments included the proportion of patients with HIV-1 RNA < 50 and < 400 copies/mL and changes in CD4 cell count from baseline to week 96. Tolerability assessments included changes in liver enzymes and lipid levels from baseline to week 96. For evaluation of efficacy, intent-to-treat analysis, in which missing values were recorded as failure (ITT), and last-observation-carried-forward (LOCF) analysis were used. Metabolic parameters were assessed using LOCF analysis.</p> <p>Results</p> <p>The analysis included 175 ART-naïve and 109 pretreated but PI-naïve patients. After 96 weeks, a similar proportion of patients in the ART-naïve and in the pretreated but Pi-naïve group had HIV-1 RNA levels < 400 copies/mL (68.0% and 70.6% [ITT], respectively; 96.6% and 90.8% [LOCF], respectively). The proportion of patients with HIV RNA < 50 copies/mL was higher in the ART-naïve group compared with the pretreated but PI-naïve group (61.1% and 56.9% [ITT], respectively; 84.0% and 75.2% [LOCF], respectively). Median change in CD4 cell count from baseline to week 96 was'+263 cells/mm³(IQR 170; 384. LOCF; p < 0.0001) in the ART-naïve group, and one line +181 cells/mm³(IQR 60; 309. LOCF; p < 0.0001) in the pretreated but PI-naïve group. Treatment was well tolerated, with only 2.5% of patients withdrawing from treatment due to side effects. There were no clinically relevant changes in liver enzyme levels. Overall total cholesterol, triglyceride, and low-and high-density lipoprotein levels increased to week 96, although levels remained within normal ranges in the majority of ART-naïve and pretreated patients.</p> <p>Conclusions</p> <p>This follow-up analysis confirms the long term efficacy and tolerability of SQV/r in ART-naïve and pretreated but PI-naïve patients in the real-life clinical setting.</p

Safety and efficacy after switch to a saquinavir-containing antiretroviral regimen in protease inhibitor pretreated HIV-positive patients

<p>Abstract</p> <p>Objective</p> <p>The RAINBOW survey is a multinational observational study assessing the tolerability and efficacy of ritonavir-boosted saquinavir (SQV/r), using the 500 mg film-coated SQV formulation, in routine clinical practice. This analysis presents data from the German subgroup of protease inhibitor (PI)-pretreated, but SQV-naïve patients.</p> <p>Methods</p> <p>Multicenter, prospective, open-label, 48 week cohort study. Efficacy assessments included the proportion of patients with HIV-1 RNA < 50 and < 400 copies/mL and changes in CD4 cell count from baseline to week 48. Tolerability assessments included changes in liver enzymes and lipid levels from baseline to week 48.</p> <p>Results</p> <p>A total of 426 patients were included in the analysis. The proportion of patients with HIV RNA levels < 50 copies/mL at week 48 was 60.3% (compared with 31.7% at switch to SQV/r) (intent-to-treat, last observation carried forward analysis). After 48 weeks, median CD4 count increased by +61 cells/mm³from baseline (p < 0.01) and 60.3% of patients achieved HIV-1 RNA < 50 copies/mL. Median changes in fasting triglyceride levels (stratified according to baseline level) at week 48 were: +14 mg/dL (IQR -8; 57) for patients with baseline triglyceride < 200 mg/dL; -50 mg/dL (IQR -139; 0) for baseline triglyceride 200-750 mg/dL, and -656 mg/dL (IQR 1024; 0) for baseline triglyceride > 750 mg/dL (p < 0.01 for all). Median changes in fasting total cholesterol (TC) levels (stratified according to baseline) were +16 mg/dL (IQR -3; 43) for patients with baseline TC < 200 mg/dL (p < 0.01), -3 mg/dL (IQR -25; 25) for baseline TC 200-300 mg/dL (p = 0.4), and -47 mg/dL (IQR -87; -4) for baseline TC > 300 mg/dL (p < 0.01). No significant changes in liver enzymes or bilirubin were observed. SQV treatment was discontinued in 22% of patients, 6% due to side effects.</p> <p>Conclusions</p> <p>These data confirm the efficacy and tolerability of SQV/r in PI-experienced, SQV-naïve patients treated in a real-life clinical setting. Of particular relevance are the improvements in triglycerides and TC levels observed in patients with baseline grade III-IV elevations.</p

Dust Formation Observed in Young Supernova Remnants with Spitzer

We present dust features and masses observed in young supernova remnants (SNRs) with Spitzer IRS mapping and staring observations of four youngest supernova remnants: SNR 1E102.2-7219 (E0102) in the SMC, Cas A and G11.2-0.3 in our Galaxy, and N132D in the LMC. The spectral mapping data revealed a number of dust features which include 21 micron-peak dust and featureless dust in Cas A and 18-micron peak dust in E0102 and N132D. The 18 micron-peak feature is fitted by a mix of MgSiO$_3$ and solid Si dust grains, while the 21-micron peak dust is by a mix of silicates and FeO; we also explore dust fitting using Continuous Distribution of Ellipsoid grain models. We report detection of CO fundamental band from Cas A in near-infrared. We review dust features observed and identified in other SNRs. The dust emission is spatially correlated with the ejecta emission, showing dust is formed in SN ejecta. The spectra of E0102 show rich gas lines from ejecta including strong ejecta lines of Ne and O, including two [Ne III] lines and two [Ne V] lines which allow us to diagnostic density and temperature of the ejecta and measure the ejecta masses. E0102 and N132D show weak or lacking Ar, Si, and Fe ejecta, whereas the young Galactic SNR Cas A show strong Ar, Si, and S and weak Fe. We discuss compositions and masses of dust and association with those of ejecta and finally, dust contribution from SNe to early Universe.Comment: conference proceeding for "Cosmic Dust - Near and Far" (Heidelberg, Germany), 11pages and 7 figure