Accounting for groundwater in future city visions

City planners, urban innovators and researchers are increasingly working on ‘future city’ initiatives to investigate the physical, social and political aspects of harmonized urban living. Despite this, sustainability principles and the importance of urban groundwater are lacking in future city visions. Using London as a case study, the importance of groundwater for cities is highlighted and a range of future city interventions may impact on groundwater are reviewed. Using data from water resource plans and city planning strategies, changes in the groundwater balance which may occur as a result of city interventions are calculated for two future city scenarios: a ‘strategic’ future informed by organisational policy and an ‘aspirational’ future guided by sustainability principles. For London, under a strategic future, preferential investment in industry-scale technologies such as wastewater treatment and groundwater storage would occur. Acknowledgement that behaviour change offers the potential for a faster rate of transformation than innovation technologies is ignored. The capacity of community-led action and smart-home technologies to deliver sustainable water use under an aspirational future is evident, with a measurable impact on urban groundwater. These methods may be used to inform city interventions that consider the social context in addition to environmental constraints and business drivers

Fecal Calprotectin Predicts Mucosal Healing in Patients With Ulcerative Colitis Treated With Biological Therapies: A Prospective Study

INTRODUCTION: Biological therapies are widely used for the treatment of ulcerative colitis. However, only a low proportion of patients achieve clinical remission and even less mucosal healing. There is currently scarce knowledge about the early markers of therapeutic response, with particular regard to mucosal healing. The aim of this prospective study was to evaluate the role of fecal calprotectin (FC) as early predictor of mucosal healing. METHODS: A prospective observational study was conducted on patients with ulcerative colitis, who started biological therapy with infliximab, adalimumab, golimumab, or vedolizumab at our center. All patients underwent colonoscopy, performed by 2 blinded operators, at baseline and week 54 or in case of therapy discontinuation because of loss of response. FC was assessed at baseline and week 8 and evaluated as putative predictor of mucosal healing at week 54. RESULTS: We enrolled 109 patients, and 97 were included in the analysis. Twenty-six patients (27%) experienced loss of response. Over 71 patients (73%) with clinical response at week 54, clinical remission was obtained in 60 patients (61.9%) and mucosal healing in 45 patients (46.4%). After 8 weeks of treatment, FC predicted mucosal healing at week 54 (P < 0.0001). Sensitivity, specificity, positive predictive value, and negative predictive value were estimated to be 75%, 88.9%, 86.6%, and 75.5%, respectively, based on a cutoff of 157.5 mg/kg. DISCUSSION: The present study suggests that FC assessment after 8 weeks of treatment with all the biological drugs could represent a promising early marker of response to therapy in terms of mucosal healing

Recognizing anthropogenic modification of the subsurface in the geological record

Humankind, in its technological development, is increasingly utilizing both mineral resources from Earth's interior and developing the rock mass as a resource in itself. In this paper we review the types of anthropogenic intrusion, at different depth ranges, that can modify the physical structure and chemistry of the subsurface. Using examples from across the world, but with emphasis on the UK, and physical models of the induced modifications, we predict what kind of subsurface signatures a geologist of the future might recognize as anthropogenic, including boreholes, tunnels and caverns, waste and resource storage facilities, mineral workings and military test traces. The potential of these anthropogenic signatures to be discriminated from natural analogues is discussed against known or modelled processes of deterioration and transformation over geological timescales of millennia or longer

From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

Fecal calprotectin (FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases (IBD). Many different methods of assessment have been developed and different cutoffs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome (IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. In IBD patients a correlation with both mucosal healing and histology was found, and there is increasing evidence that FC assessment can be helpful in monitoring disease activity and response to therapy as well as in predicting relapse, post-operative recurrence or pouchitis. Recently, its use in the context of a treat-to-target approach led to a better outcome than clinically-based therapy adjustment in patients with early Crohn’s disease. In conclusion, FC measurement represents a cheap, safe and reliable test, easy to perform and with a good reproducibility. The main concerns are still related to the choice of the optimal cut-off, both for differentiating IBD from IBS, and for the management of IBD patients

Evaluation of cytokine levels as putative biomarkers to predict the pharmacological response to biologic therapy in inflammatory bowel diseases

Cytokines play a central role in the pathogenesis of inflammatory bowel diseases. For this reason, the vast majority of biological therapies are aimed to block pro-inflammatory cytokines or their receptors. Although these drugs have modified the course of the disease due to their efficacy, a high rate of non-response or loss of response over time is still an important issue for clinicians. In this perspective, many studies have been conducted in recent years to individuate a reliable biomarker of therapeutic response. In this review, we discuss the role of cytokines involved in the pathogenesis and in the therapy of inflammatory bowel diseases, and their putative use as pharmacological biomarkers of therapy responsiveness

Recovery Monitoring in Haiti after Hurricane Matthew Through Markov Random Fields and A Region-Based Approach

The monitoring of the recovery phase in the aftermath of an emergency scenario is tackled in this paper in terms of a change-detection perspective and through the integration of multisensor, multisource, and contextual information associated with high resolution optical and SAR data. The method makes use of the Markov random field theory to integrate the spatial context and the temporal correlation associated with images acquired at different dates. Moreover, the adoption of a region-based approach allows the characterization of the geometrical structures in the images through the employment of multiple segmentation maps at different scales. The performances of the proposed approach are evaluated on pairs of COSMO-SkyMed/Pl\ue9iades images acquired over Haiti in the aftermath of Hurricane Matthew

Holistic approach to stone heritage preservation on rock masses: experience at Gozo Citadel, Malta

Conservation of outdoor stone heritage built on unstable rock masses can benefit from a holistic approach which leads to an analysis of instability mechanisms of the geologic substratum, deterioration processes of the architectural surfaces and their mutual relationships over time. An analytical procedure combining on site and laboratory diagnostic investigations is here proposed, to deal with the conservation issues due to weathering in historic hilltop towns where the construction and restoration materials share petrographic properties and similar deterioration phenomena with the rocks of the substratum. Conventional and recently developed minero-petrographic, chemical and geotechnical tests were employed to analyze rock and stone samples from the calcareous rock mass, historical masonries and underwalls of the Citadel fortifications in Gozo, Malta. Appearance and spatial distribution of erosion patterns visible on the cliff surfaces were correlated to the rock textural properties, while the morphological study and mapping of the ledges and recesses clarified the past instability events and current rockfall hazard for the enceintes. Diagnosis of stone deterioration highlighted the intrinsic weaknesses of the historically used restoration and mitigation strategies. The identification of the most critical sectors led to the installation of on site monitoring system, to early warn in case of (re)activation of block detachment and/or tilting of the walls

Instability mechanisms affecting cultural heritage sites in the Maltese Archipelago

The superimposition of geological formations with marked contrast in geotechnical properties presents one of the most critical environments for slope instability due to the different response of the materials to the applied disturbances. Moreover, the above-mentioned geological setting is often associated with high risk conditions, since many isolated rock slabs located at a higher altitude than the surrounding countryside have been sites of historical towns or buildings. The purpose of the present paper is to investigate the mechanisms determining instability in rock slabs overlying a soft substratum, with reference to two cultural heritage sites in Malta. Accurate investigations have been carried out to evaluate the geological, geotechnical and geomechanical properties together with the main geomorphological features of the soft clayey substratum and the overlying limestone rock mass. The main instability processes have thus been identified and investigated through kinematic analyses and numerical modeling, combined with a 1992–2001 Persistent Scatterers monitoring of ground displacements. The study constitutes the basis for the subsequent restoration works