Analyzing Childlessness

Childlessness has been on the rise in many European societies. In Germany, the UK, Austria, the Netherlands, and Switzerland, childlessness has increased starting with the 1950s cohorts. In these countries, about 20 % of the women born around 1965 will remain childless. In southern Europe and the former state-socialist countries of Central and Eastern Europe, the rise in levels of childlessness is a more recent phenomenon. Yet among younger cohorts in these countries, childlessness has reached levels of 15 % or higher. In this introductory chapter, we summarize the long-term trends in childlessness and discuss the differences between European countries in the prevalence of childlessness. We also outline the structure and the logic of this volume

Pasquale del Pezzo, Duke of Caianello, Neapolitan mathematician

This article is dedicated to a reconstruction of some events and achievements, both personal and scientific, in the life of the Neapolitan mathematician Pasquale del Pezzo, Duke of Caianello

A Patient-Specific Foot Model for the Estimate of Ankle Joint Forces in Patients with Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is the leading cause of childhood disability from a musculoskeletal disorder. It generally affects large joints such as the knee and the ankle, often causing structural damage. Different factors contribute to the damage onset, including altered joint loading and other mechanical factors, associated with pain and inflammation. The prediction of patients' joint loading can hence be a valuable tool in understanding the disease mechanisms involved in structural damage progression. A number of lower-limb musculoskeletal models have been proposed to analyse the hip and knee joints, but juvenile models of the foot are still lacking. This paper presents a modelling pipeline that allows the creation of juvenile patient-specific models starting from lower limb kinematics and foot and ankle MRI data. This pipeline has been applied to data from three children with JIA and the importance of patient-specific parameters and modelling assumptions has been tested in a sensitivity analysis focused on the variation of the joint reaction forces. This analysis highlighted the criticality of patient-specific definition of the ankle joint axes and location of the Achilles tendon insertions. Patient-specific detection of the Tibialis Anterior, Tibialis Posterior, and Peroneus Longus origins and insertions were also shown to be important

State-of-the-art report childlessness in Europe

In the last decades, European societies have experienced changes in the postponement of the age of having a first child, shrinking family size, and increased (in)voluntary childlessness. This report provides a review of the state-of-the-art research in relation to one of the central research goals of Working Package 4: to examine the rise, determinants and societal consequences of childlessness by different perspectives. The report provides an overview of the central macro-level determinants of childlessness among women and men firstly from a quantitative perspective examining trends, relevant determinants and measures. We will then outline the central micro-level determinants of childlessness among women, men and couples by examining core characteristics of childless individuals such as higher education or marital disruption. We then turn to an overview of anthropological and qualitative examinations of the determinants of childlessness and the psychological, social and socio-political consequences of childlessness. A reflection on potential data sources to study childlessness and a discussion on research gaps are offered in the concluding chapters. </p

State-of-the-art report childlessness in Europe

In the last decades, European societies have experienced changes in the postponement of the age of having a first child, shrinking family size, and increased (in)voluntary childlessness. This report provides a review of the state-of-the-art research in relation to one of the central research goals of Working Package 4: to examine the rise, determinants and societal consequences of childlessness by different perspectives. The report provides an overview of the central macro-level determinants of childlessness among women and men firstly from a quantitative perspective examining trends, relevant determinants and measures. We will then outline the central micro-level determinants of childlessness among women, men and couples by examining core characteristics of childless individuals such as higher education or marital disruption. We then turn to an overview of anthropological and qualitative examinations of the determinants of childlessness and the psychological, social and socio-political consequences of childlessness. A reflection on potential data sources to study childlessness and a discussion on research gaps are offered in the concluding chapters. </p

XL Premio Scanno - Provincia de L'Aquila "Riccardo Tanturri"

Il Premio Scanno nasce per iniziativa di Riccardo Tanturri De Horatio, professore universitario di Lingua e Letteratura Italiana, scrittore, poeta e giornalista. Nel 1972 diventa presidente della locale Azienda di soggiorno e turismo di Scanno e da allora si dedica a promuovere l'immagine del piccolo centro abruzzese nel mondo, fino alla sua morte. Successivamente, il coronamento del suo desiderio viene affidato a un prestigioso Comitato d'onore e a un efficiente Comitato promotore, che perpetuano il Premio e le accrescono la fama

Left ventricular mass and function in children with growth hormone (GH) deficiency before and during 12 months GH replacement therapy

OBJECTIVE: This open, prospective study was designed to evaluate the effect of GH deficiency (GHD) on left ventricular (LV) mass (LVM) and performance, by echocardiography, and on lipid profile during childhood. SUBJECTS: Twelve prepubertal children with GHD (eight boys and four girls) aged 8.1 +/- 1.7 years were studied before and after 6 and 12 months of GH replacement therapy at a dose of GH of 30 micro g/kg/day. Twelve healthy children sex-, height-, weight- and body surface area-matched with the patients, served as controls. METHODS: Echocardiography was performed at study entry and after 12 months both in GHD children and in controls. Only in GHD children, echocardiography was repeated also after 6 months of GH replacement. In all subjects, we measured LV posterior wall thickness (LVPWT), LV end-diastolic diameter (LVEDD), LVM index (LVMi), LV systolic and diastolic function. RESULTS: At study entry, LVPWT (5.3 +/- 0.8 vs. 6.2 +/- 1.1 mm, P < 0.05), LVEDD (34.0 +/- 2.4 vs. 36.7 +/- 2.1 mm, P < 0.007) and LVMi (47.0 +/- 6.9 vs. 59.6 +/- 9.5 g/m2, P < 0.005) were significantly lower in GHD children than in controls. Lipid profile, heart rate, blood pressure, LV systolic function and indices of ventricular filling were similar in patients and controls. After 12 months of GH replacement therapy, LVPWT (6.1 +/- 0.7 mm, P < 0.0005), LVEDD (38.8 +/- 4.3 mm, P < 0.002) and LVMi (71.5 +/- 12.7 g/m2, P < 0.0005) significantly increased in GHD children compared to pretreatment values. In particular, after 12 months of therapy GHD children achieved a normal LVMi when compared to controls (60.7 +/- 8.6, P = ns). LVMi increase was significantly correlated with the increase in IGF-I level (r = 0.49; P < 0.004). LV systolic performance, diastolic filling and blood pressure did not change significantly during GH therapy. After 12 months of treatment, the atherogenic index, measured as total/high-density lipoprotein-cholesterol ratio (2.7 +/- 0.8) was significantly lower than both pretreatment (3.4 +/- 0.3, P < 0.03) and control values (3.8 +/- 1.1, P < 0.04). CONCLUSIONS: GH deficiency in children affects heart morphology, by inducing a significant decrease in cardiac size, but does not modify cardiac function and lipid profile. Twelve months of GH replacement treatment normalizes cardiac mass, and reduces the atherogenic index