579 research outputs found
On the "generalized Generalized Langevin Equation"
In molecular dynamics simulations and single molecule experiments,
observables are usually measured along dynamic trajectories and then averaged
over an ensemble ("bundle") of trajectories. Under stationary conditions, the
time-evolution of such averages is described by the generalized Langevin
equation. In contrast, if the dynamics is not stationary, it is not a priori
clear which form the equation of motion for an averaged observable has. We
employ the formalism of time-dependent projection operator techniques to derive
the equation of motion for a non-equilibrium trajectory-averaged observable as
well as for its non-stationary auto-correlation function. The equation is
similar in structure to the generalized Langevin equation, but exhibits a
time-dependent memory kernel as well as a fluctuating force that implicitly
depends on the initial conditions of the process. We also derive a relation
between this memory kernel and the autocorrelation function of the fluctuating
force that has a structure similar to a fluctuation-dissipation relation. In
addition, we show how the choice of the projection operator allows to relate
the Taylor expansion of the memory kernel to data that is accessible in MD
simulations and experiments, thus allowing to construct the equation of motion.
As a numerical example, the procedure is applied to Brownian motion initialized
in non-equilibrium conditions, and is shown to be consistent with direct
measurements from simulations
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Artiklen præsenterer resultaterne af en undersøgelse lavet i Zambia med 177 respondenter i alderen 10-16 år. Undersøgelsen fokuserer på barnet samt på lokalsamfund med sportsakademier. Sportens indflydelse på udsatte børn analyseres ved hjælp af Marsh teori om selvopfattelse
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Surface defects reduce Carbon Nanotube toxicity in vitro
The cytotoxicity of two different types of Multi-walled Carbon Nanotubes (MWCNTs)in A549 lung epithelial cells and HepG2 hepatocytes was investigated. One MWCNT still contained iron that was used as a catalyst during production, while the other one had all iron removed in a post-production heat treatment resulting in significantly fewer surface defects. The WST-8 assay was applied to test cell viability. To check the integrity of the cell membrane, we performed the lactate dehydrogenases assay (LDH)and measured the cellular production of reactive oxygen species (ROS). Finally, to examine cell proliferation, we conducted a cell cycle analysis. The results showed a dose- and time-dependent decrease in cell viability for both MWCNTs in both cell types. Moreover, a dose- and time-dependent increase in LDH leakage was detected, thereby indicating a decreased membrane integrity. The production of ROS was significantly increased in the case of the heat-treated MWCNTs. The heat-treated MWCNTs showed significantly stronger adverse effects when compared to the non-treated MWCNTs. Additionally, the heat-treated MWCNTs induced a dose-dependent cell cycle arrest in A549 cells. Both MWCNTs induced a significant cytotoxicity, whereby the heat treatment, leading to a decrease in surface defects, further increased the indicated adverse effects. © 2019 The Author
Differential Effects of Digoxin on Imiquimod-Induced Psoriasis-Like Skin Inflammation on the Ear and Back
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