The Effect of Stevia Rebaudiana on Serum Omentin and Visfatin Level in STZ-Induced Diabetic Rats

Recently the role of adipocytokines in relationship to incidence of diabetes has been demonstrated. One of the medicinal plants that are used in the treatment of diabetes is stevia. This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. Forty male wistar rats weighing 180–250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). The animals were divided into 5 groups of 8. Rats in group 1 (non-diabetic control) and group 2 (diabetic control) were treated with distilled water, and the rats in the treated groups, group 3 (T250), group 4 (T500), and group 5 (T750) were treated with stevia, gavaged every day at 9 a.m. in doses of 250, 500, and 750 mg/kg, respectively. At the end of the study significant reductions in fasting blood sugar (FBS), the homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), alkaline phosphatase (ALP), and Omentin level were found in groups 3 and 4 in comparison with group 2. Pancreatic histopathology slides demonstrated that stevia extract did not induce any increase in the number of β-cells. The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. KEYWORDS. Diabetes, omentin, stevia, visfati

The investigation of limiting factors of earnings management for companies’ listed Tehran stock exchange

The current study was to examine the limiting factors of earnings management for companies’ listed Tehran stock exchange. The study was a kind of applied, descriptive- correlative research. All listed companies in Tehran stock exchange were selected as  statistical population during 2009 to 2013. So, data was gathered by library method  and collected by systematic eliminated sampling method. The results show that there is  a significant inverse relationship between board size and earnings management in companies’ listed Tehran stock exchange. The result doesn’t show any significant relationship between dividend and earnings management in companies’ listed Tehran stock exchange.Keywords: real earnings management; accrual earnings management; discretionary accruals; non-discretionary accruals; intensive factor

Application of radar and optical satelite imagery data in landslide potential mapping of Shesheer Sub-Catchment in Iran

One of the serious dangers which threatens human communities especially those who are living in mountainous areas is the occurrence of landslides. Therefore, determination of the areas with potential for landslide events is very important for avoiding establishment of residential areas or industrial facilities. The aim of this study is to provide a landslide potential map in Sheshpeer sub-catchment, Iran, using an integration of remote sensing (RS) techniques and geographical information systems (GIS). Compared with the traditional approaches, these techniques are very fast, inexpensive and trustworthy in landslide mapping. For this purpose, we collected and produced seven data layers using GIS and RS, and then Analytic Hierarchy Process (AHP) method was applied for data analysis. Our results showed that among the twelve pervious landslide events in this area, nine of them are located in the regions with very high potentiality and the others are in highly potential regions for landslides occurrence

Investigation of spectral characteristics of carbonate rocks – A case study on Posht Moleh Mount in Iran

Recent developments in the image processing approaches and the availability of multi and/or hyper spectral remote sensing data with high spectral, spatial and temporal resolutions have made remote sensing technique of great interest in investigations of geological sciences. One of the biggest advantage of the application of remote sensing in geology is recognizing the type of unknown rocks and minerals. In this study, an investigation on spectral features of carbonate rocks (i.e. calcite, dolomite, and dolomitized calcite) were done in terms of main absorptions, the reasons of those absorptions and comparison of these absorption with Johns Hopkins University (JHU) spectral library and laboratory spectra of Analytical Spectral Devices (ASD) instrument. For this purpose, we used the VNIR and SWIR bands of ASTER and OLI datasets. Finally, we applied the Spectral Analyst Algorithm in order to comparison between the obtained spectra from ASTER dataset and carbonate spectra of JHU spectral library

Effect of Spectral Bandwidths on Linear Feature Extraction: An Evaluation of Landsat ETM+ and OLI Sensors

Hitherto there have been many studies comparing the usefulness of OLI and ETM+ sensors for linear feature extraction. However, not too much attention has been paid to the differences in the bandwidth of the two sensors. In this study, the suitability of Landsat ETM+ and OLI sensors for automatic detection of linear features by LINE algorithm was compared. In this study, eight regions in northern, central and southern parts of Iran were selected based on the diversity of lithology, the pristine status, and lack of human activities for the comparison of the two datasets. Results revealed that LINE algorithm performed better on the images with higher standard deviation. The ETM+ datasets are more suitable for linear feature extraction because ETM+ panchromatic band and first principal component analysis image (PC1 image) of ETM+ datasets have higher standard deviation compared to OLI datasets

Calculation of Real Evapotranspiration by the Application of Metric Method on Landsat-8 Data

In geological remote sensing approaches for estimating evapotranspiration, METRIC method is among the most modern and precise approaches that many positive experiments have been reported regarding its applicability. In this study, the value of actual evapotranspiration (ET) occurred in Marvdasht farmlands, Fars province, Iran, was calculated instantaneously (hourly) and daily (24 hours), at 24 April 2017 using METRIC method and Lansat-8 data. In order to accuracy assessment of the results, estimated values were compared to the values calculated with Penman Monteith method in places that covers by alfafa crop. Our observations showed that ET values obtained via METRIC model on average, have 0.51mm difference in estimations, comparing to the Penman Manteith method

Identification of bioactive candidate compounds responsible for oxidative challenge from hydro-ethanolic extract of Moringa oleifera leaves.

Free radicals trigger chain reaction and inflict damage to the cells and its components, which in turn ultimately interrupts their biological activities. To prevent free radical damage, together with an endogenous antioxidant system, an exogenous supply of antioxidant components to the body in the form of functional food or nutritional diet helps undeniably. Research conducted by the Natl. Inst. of Health claimed that Moringa oleifera Lam possess the highest antioxidant content among various natural food sources based on an oxygen radical absorbent capacity assay. In this study, a 90% (ethanol:distilled water—90:10) gradient solvent was identified as one of the best gradient solvents for the effectual extraction of bioactive components from M. oleifera leaves. This finding was confirmed by various antioxidant assays, including radical scavenging activity (that is, 1, 1-diphenyl-2-picrylhydrazyl, H2O2, and NO radical scavenging assay) and total antioxidant capacity (that is, ferric reducing antioxidant power and molybdenum assay). High-performance liquid chromatography (HPLC) fingerprints of the 90% gradient extract visually showed few specific peaks, which on further analysis, using HPLC–DAD–ESI–MS, were identified as flavonoids and their derivatives. Despite commonly reported flavonoids, that is, kaempferol and quercetin, we report here for the 1st time the presence of multiflorin-B and apigenin in M. oleifera leaves. These findings might help researchers to further scrutinize this high activity exhibiting gradient extract and its bio-active candidates for fruitful clinical/translational investigations

A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly

Age is associated with increased risk for several disorders including dementias, cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with cognitive decline particularly in cognitive domains associated with memory and processing speed. With increasing life expectancies in many countries, the number of people experiencing age-associated cognitive impairment is increasing and therefore from both economic and social terms the amelioration or slowing of cognitive aging is an important target for future research. However, the biological causes of age associated cognitive decline are not yet, well understood. In the current review, we outline the role of inflammation in cognitive aging and describe the role of several inflammatory processes, including inflamm-aging, vascular inflammation, and neuroinflammation which have both direct effect on brain function and indirect effects on brain function via changes in cardiovascular function

Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity:a cross-sectional study

Abstract Background Previous studies have shown that the minor allele (C allele) for Cry 1 rs2287161, may be associated with increased risk of cardiovascular diseases (CVDs). Low resting metabolic rate (RMR) caused by the diet has been shown to have, potentially, unfavorable effects on obesity. This study sought to investigate the interactions between the Cry 1 Gene and fat intake on RMR in women with overweight of obesity. Methods This comparative cross-sectional study was conducted on 377 Iranian women with overweight of obesity. A food frequency questionnaire (FFQ), with 147 items, was used to assess dietary intake. Individuals were categorized into two groups based on the rs2287161 genotype. Body composition, dietary intake, and RMR were assessed for all participants. Results There was a significant difference between genotypes for fasting blood sugar (FBS) (P = 0.04), fat free mass (FFM) (P = 0.0009), RMR per FFM (P = 0.05), RMR per body mass index (BMI) (P = 0.02), and RMR deviation (P = 0.01). Our findings also showed significant interactions between total fat and C allele carrier group on RMR per kg body weight, RMR per body surface area (BSA), RMR per FFM, and RMR deviation (P for interaction < 0.1), in addition to a significant interaction between CC + CG group genotype and polyunsaturated fatty acids (PUFA) intake on RMR per BMI (P for interaction =0.00) and RMR per kg (P for interaction = 0.02) and RMR per BSA (P = 0.07), compared to the GG group, after control for confounder factors. Conclusion These results highlight that dietary compositions, gene variants, and their interaction, should be acutely considered in lower RMR

Calcium to magnesium intake ratio and non-alcoholic fatty liver disease development: a case-control study

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Adoption of sedentary life style and westernized diet are shown to be associated with development of NAFLD. Since previous studies suggested that calcium (Ca) to magnesium (Mg) ratio intake is associated with some chronic diseases including dyslipidemia and insulin resistance, we designed this study to find any possible association between this ratio and NAFLD development. Methods: The NAFLD was diagnosed using Fibroscan according to a CAP cut-off value of 263 dB/m. Dietary intakes of one hundred and ninety-six patients with incident NAFLD diagnosis, and eight hundred and three controls without NAFLD were assessed using a valid food frequency questionnaire (FFQ). Dietary nutrients were calculated using Nutritionist IV software. Results: Age of the study population (57 % female) was 43.2 ± 14.1 years. In addition, energy-adjusted daily calcium to magnesium intake ratio was 2.34 ± 0.57 and 2.73 ± 0.69 for control and case groups, respectively. In the multivariable-adjusted model, after adjustment for potential confounding variables; including, age, gender, BMI, alcohol consumption, smoking, diabetes, physical activity, energy, dietary fiber, carbohydrate, fat, and protein intakes, participants in the third (Q3) and fourth (Q4) quartile of Ca/Mg ratio intake had a greater development of incidental NAFLD compared to the lowest quartile (Q1) [(OR = 2.86; 95 % CI: 1.20–6.81), (P-value = 0.017) and (OR = 5.97; 95 % CI: 2.54–14.01), (P-value < 0.001) for Q3 and Q4 compared to the Q1, respectively]. Moreover, energy-adjusted Ca to Mg intake ratio was positively correlated with plasma level of ALT (r = 0.18; P = 0.01); contrarily, it had no correlation with plasma levels of AST. Conclusions: The current study revealed that higher dietary Ca to Mg intake ratio is associated with a greater development of NAFLD. Further interventional studies are needed to confirm the causal relationship of the Ca/Mg ratio intake and development of NAFLD