3D digital technologies for architectural analysis. The case of the ‘Pagan Shrine’ in the Catacombs of Santa Lucia (Siracusa, Sicily)

The Catacombs of Santa Lucia are one of the oldest and most important monuments in the Christian communities of Siracusa and Sicily in the late Roman period. The name of the complex derives from a tradition, according to which Saint Lucy was buried here, after her martyrdom in the early 4th century AD, under the reign of Diocletian. A large underground cemetery extends beneath the homonymous square. The cemetery gradually expanded from the 3rd to the 5th century AD, as it incorporated pre-existing constructions once used for funerary, religious and industrial purposes, by transforming them into monumental burial chambers. One of the most significant structures is the so-called ‘Pagan Shrine’: a chamber that is dated between the 3rd century BC and 1st century AD, prior to the foundation of the cemetery and frescoed with worldly themes and pagan deities. The Shrine is located in the South-western corner of Regio C, an area that is hard and rather dangerous to reach, never opened to the public and visited only by few scholars over the past decades. The excavation project undertaken in the years 2011-2015 by the Pontifical Commission of Sacred Archaeology, in association with the Arcadia University and the University of Catania, led to the development of the first virtual replica of the Shrine, using Digital Photogrammetry. This new approach facilitated an accurate examination of both its structure and its decoration, allowing us to propose a new theory about the original purpose of the room, traditionally regarded by scholars as a place for worshipping Zeus Peloros

Diet and mobility in Late Antique Sicily: Isotopic data from the catacombs of Santa Lucia, Siracusa (Italy)

The catacombs of Santa Lucia were built during the 3rd century CE in Siracusa, Sicily, Italy, as a burial site for members of the local Christian community until the early 8th century CE. This site is an important cemeterial context of the Late Roman and Byzantine periods. The tombs and artifacts found suggest that individuals of varying wealth were buried in the catacombs. Historical accounts also confirm the presence of a significant Christian community from Syria and the Levant in Siracusa during this period. The objective of this research is to investigate the life histories of the Late Antique community interred in the catacombs using stable isotope analysis. This technique aimed to clarify the dietary differences between individuals of different social status and geographical origins, in order to re-evaluate the data from historical documents. To achieve this, we conducted stable carbon, nitrogen, and oxygen isotope analyses on skeletal samples from 25 individuals recovered from the catacombs of Santa Lucia, using established methods. The results revealed significant dietary diversity among the individuals buried in the catacombs, with evidence of the consumption of both C3 and C4 plants, as well as fish from both freshwater and sea sources. The oxygen isotopes show a particularly broad range in both the small sample set of bones and the larger set of teeth, suggesting a significant degree of mobility for most of the individuals tested. The high variability found in the diet and the evidence of mobility for most of the individuals tested not only between early age and adulthood, but also throughout their lives. It raises new questions and calls for the consideration of the archaeological and historical implications of these novel discoveries

Quelles compétences et littératies pour les humanités numériques ?

Un atelier qui concerne également l'identification de compétences. Question qui se pose souvent dans le cadre de projet. L'idée serait d'identifier ces compétences afin de contribuer à la définition de formations pour pouvoir disposer des personnes qui aient cette somme de compétences nécessaire pour monter des projets ambitieux. Sans doute faire un début de cartographie avec du mindmapping pour identifier des compétences clefs à développer dans les formations. L'objectif est de débattre sur les compétences et littératies nécessaires pour s'investir dans les humanités numériques. Quelles sont les compétences numériques, informatiques et intellectuelles pour y parvenir.  Faut-il faire évoluer les formations actuelles ? L'objectif est de tenter de dessiner une matrice des compétences minimales et d'envisager celles qui seront nécessaires à l'avenir pour accueillir et former les futurs chercheurs notamment en SHS.

The serological prevalence of SARS-CoV-2 infection in patients with chronic myeloid leukemia is similar to that in the general population

Background: Patients with hematological malignancies are at an increased risk of SARS-CoV-2 disease (COVID-19) and adverse outcome. However, a low mortality rate has been reported in patients with chronic myeloid leukemia (CML). Preclinical evidence suggests that tyrosine kinase inhibitors (TKIs) may have a protective role against severe COVID-19. Methods: We conducted a cross-sectional study of 564 consecutive patients with CML who were tested for anti-SARS-CoV-2 IgG/IgM antibodies at their first outpatient visit between May and early November 2020 in five hematologic centers representative of three Italian regions. Results: The estimated serological prevalence of SARS-CoV-2 infection in patients with CML after the first pandemic wave was similar to that in the general population (about 2%), both at national and regional levels. CML patients with positive anti-SARS-CoV-2\ua0serology were more frequently male (p\ua0=\ua00.027) and active workers (p\ua0=\ua00.012), while there was no significant association with TKI treatment type. Only 3 out of 11 IgG-positive patients had previously received a molecular diagnosis of COVID-19, while the remainders were asymptomatic or with mild symptoms. Conclusions: Our data confirm that the course of SARS-CoV-2 infection in patients with CML is generally mild and reassure about the safety of continuing TKIs during the COVID-19 pandemic. Furthermore, we suggest that patients with CML succeed to mount an antibody response after exposure to SARS-CoV-2, similar to the general population

Incidence, treatment and outcome of central nervous system relapse in adult acute lymphoblastic leukaemia patients treated front-line with paediatric-inspired regimens: A retrospective multicentre Campus ALL study

Within the Campus ALL network we analyzed the incidence, characteristics, treatment and outcome of a central nervous system (CNS) relapse in 1035 consecutive adult acute lymphoblastic leukemia (ALL) patients treated frontline with pediatric-inspired protocols between 2009 and 2020. Seventy-one patients (6.8%) experienced a CNS recurrence, more frequently in T- (28/278; 10%) than in B-ALL (43/757; 5.7%) (p = 0.017). An early CNS relapse—< 12 months from diagnosis—was observed in 41 patients. In multivariate analysis, risk factors for early CNS relapse included T-cell phenotype (p = <0.001), hyperleucocytosis >100 × 109/L (p<0.001) and male gender (p = 0.015). Treatment was heterogeneous, including chemotherapy, radiotherapy, intrathecal therapy and novel agents. A complete remission (CR) was obtained in 39 patients (55%) with no differences among strategies. After CR, 26 patients underwent an allogenic transplant, with a significant overall survival benefit compared to non-transplanted patients (p = 0.012). After a median observation of 8 months from CNS relapse, 23 patients (32%) were alive. In multivariate analysis, the time to CNS relapse was the strongest predictor of a lower 2-year post-relapse survival (p<0.001). In conclusion, in adult ALL the outcome after a CNS relapse remains very poor. Effective CNS prophylaxis remains the best approach and allogenic transplant should be pursued when possible

Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: a Campus ALL study

Blinatumomab is the first bi-specific T-cell engager approved for relapsed or refractory B-cell precursor acute lymphoblastic leukaemia (B-ALL). Despite remarkable clinical results, the effects of blinatumomab on the host immune cell repertoire are not fully elucidated. In the present study, we characterized the peripheral blood (PB) and, for the first time, the bone marrow (BM) immune cell repertoire upon blinatumomab treatment. Twenty-nine patients with B-ALL received blinatumomab according to clinical practice. Deep multiparametric flow cytometry was used to characterize lymphoid subsets during the first treatment cycle. Blinatumomab induced a transient redistribution of PB effector T-cell subsets and Treg cells with a persistent increase in cytotoxic NK cells, which was associated with a transient upregulation of immune checkpoint receptors on PB CD4 and CD8 T-cell subpopulations and of CD39 expression on suppressive Treg cells. Of note, BM immune T-cell subsets showed a broader post-treatment subversion, including the modulation of markers associated with a T-cell-exhausted phenotype. In conclusion, our study indicates that blinatumomab differentially modulates the PB and BM immune cell repertoire, which may have relevant clinical implications in the therapeutic setting

Virtual Acropolis. Digital recreation of a Sicilian Archaic sanctuary

This paper deals with a project of virtual reconstruction of an entire archaeological site, the Sicilian Archaic sanctuary on the acropolis of Polizzello Mountain. This research program, called �Virtual Acropolis� has been developed in order to allow the experience of visiting an interactive and immersive 3D environments reconstructed in all and set in a realistic landscape. A visit that in the reality is currently impossible due to the still ongoing restoration works. For improving the archaeologist�s hypotheses about rituals and performances that were carried out in the sanctuary, all votive objects and offerings were digitally recreated and located in their original position and an avatar of a worshipper was implemented within the interactive model in order to directly experience, thanks to the archaeological and literary sources collected, how was one ordinary day in an Archaic sanctuary. Furthermore, the application of this technique represents the more recent frontier in the policies aimed to promotion of cultural and archaeological heritage.Este artículo trata de un proyecto de reconstrucción virtual integral de un sitio arqueológico, el santuario arcaico de Sicilia en la acrópolis de la Montaña de Polizzello. El programa de investigación, denominado 'Virtual Acrópolis' se ha desarrollado con el fin de permitir que la experiencia de visitar un entorno 3D reconstruido de forma completamente interactiva e inmersiva en un paisaje realista. Es una visita que es imposible realizar hoy día a causa de los trabajos de restauración aún en curso. Para mejorar la hipótesis de los arqueólogos acerca de los rituales y las actuaciones que se llevaron a cabo en el santuario, todos los objetos votivos y las ofrendas fueron recreados digitalmente y situados en su posición original. Un avatar de un adorador se usa en el modelo interactivo para experimentar cómo era un día cualquiera en este santuario arcaico. Tal recreación ha sido posible gracias a la ayuda de las fuentes arqueológicas y literarias recogidas. Además, la aplicación de esta técnica representa la frontera más reciente en las políticas dirigidas a la promoción del patrimonio cultural y arqueológico

#Izitravelsicilia: A participatory storytelling project

The aim of this paper is to present the participatory project “Sicilia Beni Culturali” on the izi.TRAVEL platform, launched in May 2016and well known on social media as #iziTRAVELSicilia. Recognized as a facilitator of best practice digital promotion and valorization through storytelling and crowdsourcing culture, it has already involved thousands of people. With over 150 audio guides produced on the platform in just over a year, #iziTRAVELSicilia has become a real model of participation in co-creation of cultural values, by practicing the principles set out by the Faro Convention. In this paper we briefly present the project and the example of the Roman Villa of Durrueli and how this platform was and can be furtherused for the dissemination of existing 3D models and for new 3D models, such as those made by the USF - CVAST virtualization project in Sicily