Observational signatures of forming young massive clusters: continuum emission from dense HII regions

Young massive clusters (YMCs) are the most massive star clusters forming in nearby galaxies and are thought to be a young analogue to the globular clusters. Understanding the formation process of YMCs leads to looking into very efficient star formation in high-redshift galaxies suggested by recent JWST observations. We investigate possible observational signatures of their formation stage, particularly when the mass of a cluster is increasing via accretion from a natal molecular cloud. To this end, we study the broad-band continuum emission from ionized gas and dust enshrouding YMCs, whose formation is followed by recent radiation-hydrodynamics simulations. We perform post-process radiative transfer calculations using simulation snapshots and find characteristic spectral features at radio and far-infrared frequencies. We show that a striking feature is long-lasting, strong free-free emission from a $\sim$ 10pc-scale HII region with a large emission measure of $\gtrsim 10^7 \mathrm{cm}^{-6} \ \mathrm{pc}$, corresponding to the mean electron density of $\gtrsim 10^3~\mathrm{cm}^{-3}$. There is a turnover feature below $\sim$ 10 GHz, a signature of the optically-thick free-free emission, often found in Galactic ultra-compact HII regions. These features come from the peculiar YMC formation process, where the cluster's gravity effectively traps photoionized gas for a long duration and enables continuous star formation within the cluster. Such large and dense HII regions show distinct distribution on the density-size diagram, apart from the standard sequence of Galactic HII regions. This is consistent with the observational trend inferred for extragalactic HII regions associated with YMCs.Comment: 12 pages, 10 figures, accepted for publication in MNRA

Protein kinase C in heart failure: a therapeutic target?

Heart failure (HF) afflicts about 5 million people and causes 300 000 deaths a year in the United States alone. An integral part of the pathogenesis of HF is cardiac remodelling, and the signalling events that regulate it are a subject of intense research. Cardiac remodelling is the sum of responses of the heart to causes of HF, such as ischaemia, myocardial infarction, volume and pressure overload, infection, inflammation, and mechanical injury. These responses, including cardiomyocyte hypertrophy, myocardial fibrosis, and inflammation, involve numerous cellular and structural changes and ultimately result in a progressive decline in cardiac performance. Pharmacological and genetic manipulation of cultured heart cells and animal models of HF and the analysis of cardiac samples from patients with HF are all used to identify the molecular and cellular mechanisms leading to the disease. Protein kinase C (PKC) isozymes, a family of serine–threonine protein kinase enzymes, were found to regulate a number of cardiac responses, including those associated with HF. In this review, we describe the PKC isozymes that play critical roles in specific aspects of cardiac remodelling and dysfunction in HF

High-density excitation effect on photoluminescence in ZnO nanoparticles

In this study, photoluminescence PL under high excitation intensity as a function of crystalline size was systematically investigated through ZnO nanocrystalline films prepared by spin-coating a colloidal solution of ZnO nanoparticles obtained using the microemulsion method. Annealing of the films at 723, 633, and 593 K allowed us to tune the crystalline radius R. PL studies distinguished different regimes of crystalline size according to the ratio of R to the effective Bohr radius aB R/aB. For the sample annealed at 723 K R/aB=7.2 , the peak of stimulated emission due to the exciton-exciton collisions appeared on the low-energy side of the exciton emission with an increase in excitation intensity. A further increase in excitation intensity eventually resulted in the occurrence of an electron-hole plasma EHP accompanied by consequent band gap renormalization, which indicates that high excitation intensity provokes the dissociation of excitons. For the sample annealed at 633 K R/aB=4.7 , the stimulated emission was observed while the transition to EHP was obscure. For the sample annealed at 593 K R/aB=2.1 , only emissions due to the recombination of the electron-hole pair were observed, and stimulated emission did not appear even when the excitation intensity was increased. The transition from free-exciton emission to donor-bound exciton emission was observed in temperature dependence of PL only for the sample with R/aB=7.2. The origin of annihilation of the stimulated emission with a size reduction is discussed based on nonradiative Auger recombination