Development of bulk-scale intelligent hydrogels using oligo DNA for biomedical applications [論文要旨及び審査の要旨]

関西大

生体応用を目指したオリゴDNAを使ったバルクスケールのインテリジェントヒドロゲル材料の開発

関西大学本論文はやむを得ない事由により要約のみを公表していましたが、事由が解消されたため、2020年11月に全文を追加しました

ゾル−ゲル転移を示す生体適合ポリマー材料の開発と応用 (2)

(1) Title: Bulk pH Responsive DNA Quadruplex Hydrogels Prepared by Liquid-Phase Large Scale DNA SynthesisJournal: ACS Macro Letters(2) Title: Communication—DNA Quadruplex Hydrogel Beads Showing Peroxidase ActivityJournal: Journal of The Electrochemical SocietyDOI: http://dx.doi.org/10.1149/2.0441909je

Photon-induced Nucleosynthesis: Current Problems and Experimental Approaches

Photon-induced reactions play a key role in the nucleosynthesis of rare neutron-deficient p-nuclei. The paper focuses on (gamma,alpha), (gamma,p), and (gamma,n) reactions which define the corresponding p-process path. The relation between stellar reaction rates and laboratory cross sections is analyzed for photon-induced reactions and their inverse capture reactions to evaluate various experimental approaches. An improved version S_C(E) of the astrophysical S-factor is suggested which is based on the Coulomb wave functions. S_C(E) avoids the apparent energy dependence which is otherwise obtained for capture reactions on heavy nuclei. It is found that a special type of synchrotron radiation available at SPring-8 that mimics stellar blackbody radiation at billions of Kelvin is a promising tool for future experiments. By using the blackbody synchrotron radiation, sufficient event rates for (gamma,alpha) and (gamma,p) reactions in the p-process path can be expected. These experiments will provide data to improve the nuclear parameters involved in the statistical model and thus reduce the uncertainties of nucleosynthesis calculations.Comment: 13 pages, 6 figures, EPJA, accepte

Investigation of Bacteremia due to Aeromonas Species and Comparison with That due to Enterobacteria in Patients with Liver Cirrhosis

Background. The role of Aeromonas species (sp.) in bacteremia in Japanese patients with liver cirrhosis is poorly understood. Aim. To establish the importance of Aeromonas sp. as a cause of bacteremia in patients with liver cirrhosis. Methods. Clinical and serological features and short-term prognosis were retrospectively investigated and compared in Japanese patients with bacteremia due to Aeromonas sp. (=11) and due to enterobacteria (E. coli, Klebsiella sp., and Enterobacter sp.) (=84). Results. There were no significant differences in patients’ clinical background, renal dysfunction, or short-term mortality rate between the two groups. However, in the Aeromonas group, the model for end-stage liver disease (MELD) score and Child-Pugh score were significantly higher than in the enterobacteria group. Conclusion. These results indicate that the severity of liver dysfunction in Aeromonas-induced bacteremia is greater than that in enterobacteria-induced bacteremia in Japanese patients with liver cirrhosis