Protective Effects of Insulin in Cardiomyocytes Against Iron-mediated Cell Death

When an acute myocardial infarction (MI) occurs, the heart becomes ischemic. Medical treatments such as stents have improved the recovery process after a MI, but there is still a high risk for heart failure. Due to the resulting intramyocardial hemorrhage, residual hemoglobin with excess iron compromises cardiomyocyte (CM) survival. Previous studies suggest that the magnitude of CM cell death is directly proportional to the level of adverse left ventricular (LV) remodeling. Mechanistic target of rapamycin (mTOR) is a key downstream signaling pathway that is sufficient for CM cell survival against iron and responds to insulin, a cardioprotective growth factor. However, the effect of insulin in excess iron-induced cell death in CMs is not well characterized. Using H9c2 cardiomyoblasts, originally derived from embryonic rat ventricle cells, the effects of insulin in CM cell survival against excess iron were examined. The cells were pre-treated with varying dosages of insulin before applying iron (III) citrate. Cell viability was assessed by Live/Dead Assay, in which live cells stain with calcein AM (green) and nuclei of dead cells stain with ethidium homodimer-1 (red). In comparison to the amount of cell death caused by iron alone, insulin decreased dead cell count substantially. The greatest concentration of 1µM of insulin with iron resulted in a statistical significance of p\u3c0.02 (n=3-4). The results indicate that insulin has the potential to mediate iron-induced CM death. Understanding the effect of insulin as a combatant of iron-induced cell death with an intramyocardial approach would lead to better therapeutic preventions of heart failure

Existence of Dynamical Scaling in the Temporal Signal of Time Projection Chamber

The temporal signals from a large gas detector may show dynamical scaling due to many correlated space points created by the charged particles while passing through the tracking medium. This has been demonstrated through simulation using realistic parameters of a Time Projection Chamber (TPC) being fabricated to be used in ALICE collider experiment at CERN. An interesting aspect of this dynamical behavior is the existence of an universal scaling which does not depend on the multiplicity of the collision. This aspect can be utilised further to study physics at the device level and also for the online monitoring of certain physical observables including electronics noise which are a few crucial parameters for the optimal TPC performance.Comment: 5 pages, 6 figure

A survey of spinning test particle orbits in Kerr spacetime

We investigate the dynamics of the Papapetrou equations in Kerr spacetime. These equations provide a model for the motion of a relativistic spinning test particle orbiting a rotating (Kerr) black hole. We perform a thorough parameter space search for signs of chaotic dynamics by calculating the Lyapunov exponents for a large variety of initial conditions. We find that the Papapetrou equations admit many chaotic solutions, with the strongest chaos occurring in the case of eccentric orbits with pericenters close to the limit of stability against plunge into a maximally spinning Kerr black hole. Despite the presence of these chaotic solutions, we show that physically realistic solutions to the Papapetrou equations are not chaotic; in all cases, the chaotic solutions either do not correspond to realistic astrophysical systems, or involve a breakdown of the test-particle approximation leading to the Papapetrou equations (or both). As a result, the gravitational radiation from bodies spiraling into much more massive black holes (as detectable, for example, by LISA, the Laser Interferometer Space Antenna) should not exhibit any signs of chaos.Comment: Submitted to Phys. Rev. D. Follow-up to gr-qc/0210042. Figures are low-resolution in order to satisfy archive size constraints; a high-resolution version is available at http://www.michaelhartl.com/papers

Magnetic exchange interaction induced by a Josephson current

We show that a Josephson current flowing through a ferromagnet-normal-metal-ferromagnet trilayer connected to two superconducting electrodes induces an equilibrium exchange interaction between the magnetic moments of the ferromagnetic layers. The sign and magnitude of the interaction can be controlled by the phase difference between the order parameters of the two superconductors. We present a general framework to calculate the Josephson current induced magnetic exchange interaction in terms of the scattering matrices of the different layers. The effect should be observable as the periodic switching of the relative orientation of the magnetic moments of the ferromagnetic layers in the ac Josephson effect.Comment: 12 pages, 7 figure

Inherent Inhomogeneities in Tunneling Spectra of BSCCO Crystals in the Superconducting State

Scanning Tunneling Spectroscopy on cleaved BSCCO(2212) single crystals reveal inhomogeneities on length-scales of $\sim$30 $\AA$. While most of the surface yields spectra consistent with a d-wave superconductor, small regions show a doubly gapped structure with both gaps lacking coherence peaks and the larger gap having a size typical of the respective pseudo-gap for the same sample.Comment: 4 pages, 4 figure

Magnetization relaxation in (Ga,Mn)As ferromagnetic semiconductors

We describe a theory of Mn local-moment magnetization relaxation due to p-d kinetic-exchange coupling with the itinerant-spin subsystem in the ferromagnetic semiconductor (Ga,Mn)As alloy. The theoretical Gilbert damping coefficient implied by this mechanism is calculated as a function of Mn moment density, hole concentration, and quasiparticle lifetime. Comparison with experimental ferromagnetic resonance data suggests that in annealed strongly metallic samples, p-d coupling contributes significantly to the damping rate of the magnetization precession at low temperatures. By combining the theoretical Gilbert coefficient with the values of the magnetic anisotropy energy, we estimate that the typical critical current for spin-transfer magnetization switching in all-semiconductor trilayer devices can be as low as $\sim 10^{5} {\rm A cm}^{-2}$.Comment: 4 pages, 2 figures, submitted to Rapid Communication

Geometry of Brane-Worlds

The most general geometrical scenario in which the brane-world program can be implemented is investigated. The basic requirement is that it should be consistent with the confinement of gauge interaction, the existence of quantum states and the embedding in a bulk with arbitrary dimensions, signature and topology. It is found that the embedding equations are compatible with a wide class of Lagrangians, starting with a modified Einstein-Hilbert Lagrangian as the simplest one, provided minimal boundaries are added to the bulk. A non-trivial canonical structure is derived, suggesting a canonical quantization of the brane-world geometry relative to the extra dimensions, where the quantum states are set in correspondence with high frequency gravitational waves. It is shown that in the cases of at least six dimensions, there exists a confined gauge field included in the embedding structure. The size of extra dimensions compatible with the embedding is calculated and found to be different from the one derived with product topology.Comment: Minor changes and a correction to equation (22). 9 pages twocolumn Revte

Analytical solution of generalized Burton--Cabrera--Frank equations for growth and post--growth equilibration on vicinal surfaces

We investigate growth on vicinal surfaces by molecular beam epitaxy making use of a generalized Burton--Cabrera--Frank model. Our primary aim is to propose and implement a novel analytical program based on a perturbative solution of the non--linear equations describing the coupled adatom and dimer kinetics. These equations are considered as originating from a fully microscopic description that allows the step boundary conditions to be directly formulated in terms of the sticking coefficients at each step. As an example, we study the importance of diffusion barriers for adatoms hopping down descending steps (Schwoebel effect) during growth and post-growth equilibration of the surface.Comment: 16 pages, REVTeX 3.0, IC-DDV-94-00

Semiclassical Instability of the Cauchy Horizon in Self-Similar Collapse

Generic spherically symmetric self-similar collapse results in strong naked-singularity formation. In this paper we are concerned with particle creation during a naked-singularity formation in spherically symmetric self-similar collapse without specifying the collapsing matter. In the generic case, the power of particle emission is found to be proportional to the inverse square of the remaining time to the Cauchy horizon (CH). The constant of proportion can be arbitrarily large in the limit to marginally naked singularity. Therefore, the unbounded power is especially striking in the case that an event horizon is very close to the CH because the emitted energy can be arbitrarily large in spite of a cutoff expected from quantum gravity. Above results suggest the instability of the CH in spherically symmetric self-similar spacetime from quantum field theory and seem to support the existence of a semiclassical cosmic censor. The divergence of redshifts and blueshifts of emitted particles is found to cause the divergence of power to positive or negative infinity, depending on the coupling manner of scalar fields to gravity. On the other hand, it is found that there is a special class of self-similar spacetimes in which the semiclassical instability of the CH is not efficient. The analyses in this paper are based on the geometric optics approximation, which is justified in two dimensions but needs justification in four dimensions.Comment: 14 pages, 4 figures, minor errors corrected and some sentences added in the introduction, accepted for publication in Physical Review

High Magnetic Field NMR Studies of LiVGe2_2O6_6, a quasi 1-D Spin S=1S = 1 System

We report $^{7}$Li pulsed NMR measurements in polycrystalline and single crystal samples of the quasi one-dimensional S=1 antiferromagnet LiVGe$_2$O$_6$, whose AF transition temperature is $T_{\text{N}}\simeq 24.5$ K. The field ($B_0$) and temperature ($T$) ranges covered were 9-44.5 T and 1.7-300 K respectively. The measurements included NMR spectra, the spin-lattice relaxation rate ($T_1^{-1}$), and the spin-phase relaxation rate ($T_2^{-1}$), often as a function of the orientation of the field relative to the crystal axes. The spectra indicate an AF magnetic structure consistent with that obtained from neutron diffraction measurements, but with the moments aligned parallel to the c-axis. The spectra also provide the $T$-dependence of the AF order parameter and show that the transition is either second order or weakly first order. Both the spectra and the $T_1^{-1}$ data show that $B_0$ has at most a small effect on the alignment of the AF moment. There is no spin-flop transition up to 44.5 T. These features indicate a very large magnetic anisotropy energy in LiVGe$_2$O$_6$ with orbital degrees of freedom playing an important role. Below 8 K, $T_1^{-1}$ varies substantially with the orientation of $B_0$ in the plane perpendicular to the c-axis, suggesting a small energy gap for magnetic fluctuations that is very anisotropic.Comment: submitted to Phys. Rev.