An Interactive System for Concurrent Engineering Design

The methods in delivering engineering design have gone through evolvement where the effectiveness of conventional methods is decreasing. However, the importance of concurrent engineering design approach has tremendously increased due to the ever competitive world today. This is the reason why engineering designers are concern about the methods of delivering design and one of the recent interests is using interactive system to deliver design. In this paper, the construction of interactive system will be discussed followed by the experimental setup. Experiments will be conducted in the form of performing few selected tasks with the interactive system and comparison will be made with the conventional design approach. Comparison will be done by collecting feedback through questionnaires from the participants who are involved in the experiments. Feedback will be analysed to identify the feasibility of interactive concurrent engineering design system

A mouse model of lamellar intrastromal femtosecond laser keratotomy: ultra-structural, inflammatory, and wound healing responses

Molecular Vision173005-3012MVEP

Microcosting in economic evaluations: Issues of accuracy, feasibility, consistency and generalisability

Omdat de diversiteit aan medische behandelingen in de afgelopen decennia enorm is gegroeid, staan de zorgbudgetten in Westerse landen voortdurend onder druk. De beslissing om bronnen voor een doeleinde aan te wenden in plaats van aan een ander doeleinde moet dus gestruktureerd worden afwogen. Deze afweging wordt doorgaans gemaakt met behulp van economische evaluaties die zowel de kosten als effecten van alternatieve medische behandelingen schatten. Hoewel de effecten van medische behandelingen minstens zo belangrijk zijn, stonden in mijn proefschrift de kosten centraal. De doelstelling was de kosten van specifieke medische behandelingen te schatten en algemene methodologische conclusies te trekken wat betreft de toepassing van drie kostenmethoden. De methoden werden toegepast in een verscheidenheid aan medische specialismen, waaronder oncologie, hematologie, intensive care medicine, tandheelkunde, huisartsgeneeskunde, cardiologie en neurochirurgie. Er bestaat nog geen consensus over de methode van voorkeur voor de kostenschatting van behandelingen. De ‘bottom up microcosting’ methode wordt over het algemeen verondersteld de meest nauwkeurige kostenschatting te geven, omdat kosten worden berekend per individuele patiënt en per individuele kostencomponent. De methode wordt echter niet op grote schaal toegepast omdat zij vanwege haar tijdsintensieve karakter nauwelijks haalbaar is. Omgekeerd wordt de ‘gross costi

Spherical Tin Oxide, SnO2 Particles Fabricated via Facile Hydrothermal Method for Detection of Mercury (II) Ions.

Smooth-surface spherical tin oxide particles were fabricated via hydrothermal processing route. X-ray diffraction (XRD) revealed that the particles consisted of the rutile phase of SnO2 with tetragonal structure. The spherical morphology was realized with the aid of ammonia. The aggregation of SnO2 particles could be avoided by adjusting the concentration of tin (II) chloride. Bare glassy carbon electrode (GCE) was modified with the hydrothermally prepared SnO2 particles to detect the presence of mercury (II) ions (Hg2+), in the presence of potassium chloride (KCl) as a supporting electrolyte. GCE modified with the spherical SnO2 particles that possessed small crystallite size and smooth surface exhibited significantly enhanced oxidative and reductive current of Hg2+ during cyclic voltammetry compared with its bare counterpart. The reductive current was observed to increase by two fold and the detection limit of 75 nM for Hg 2+ was achieved. This suggests that SnO2 particles are a promising chemical sensor for the detection of Hg2+ in natural waters

A noticeable difference? Productivity costs related to paid and unpaid work in economic evaluations on expensive drugs

Productivity costs can strongly impact cost-effectiveness outcomes. This study investigated the impact in the context of expensive hospital drugs. This study aimed to: (1) investigate the effect of productivity costs on cost-effectiveness outcomes, (2) determine whether economic evaluations of expensive drugs commonly include productivity costs related to paid and unpaid work, and (3) explore potential reasons for excluding productivity costs from the economic evaluation. We conducted a systematic literature review to identify economic evaluation

A microcosting study of the surgical correction of upper extremity deformity in children with spastic cerebral palsy

_Objective:_ Determine healthcare costs of upper-extremity surgical correction in children with spastic cerebral palsy (CP). _Method:_ This cohort study included 39 children with spastic CP who had surgery for their upper extremity at a Dutch hospital. A retrospective cost analysis was performed including both hospital and rehabilitation costs. Hospital costs were determined using microcosting methodology. Rehabilitation costs were estimated using reference prices. _Results:_ Hospital costs averaged €6813 per child. Labor (50%), overheads (29%), and medical aids (15%) were important cost drivers. Rehabilitation costs were estimated at €3599 per child. _Conclusions:_ Surgery of the upper extremity is an important contributor to the healthcare costs of children with CP. Our study shows that labor is the most important cost driver for hospital costs, owing to the multidisciplinary approach and patient-specific treatment plan. A remarkable finding was the substantial amount of rehabilitation costs

Prevalence of using pod-based vaping devices by brand among youth and young adults

An estimated 10%–44% of youth and young adults have ever used JUUL, the leading e-cigarette brand in the USA, while 8%–9% reported past 30-day use of JUUL. Although there is growing attention on the prevalence of JUUL use, prevalence of using other brands of pod-based vaping devices is unknown. This information is important to assess whether newer brands are gaining popularity among young people and to complement sales data which do not track online purchases and sales through non-participating retailers or provide information about characteristics of users.1 This study assesses the prevalence of current use of JUUL, Suorin and Vuse across demographic and tobacco use characteristics among US youth and young adults

Afshar's Experiment does not show a Violation of Complementarity

A recent experiment performed by S. Afshar [first reported by M. Chown, New Scientist {\bf 183}, 30 (2004)] is analyzed. It was claimed that this experiment could be interpreted as a demonstration of a violation of the principle of complementarity in quantum mechanics. Instead, it is shown here that it can be understood in terms of classical wave optics and the standard interpretation of quantum mechanics. Its performance is quantified and it is concluded that the experiment is suboptimal in the sense that it does not fully exhaust the limits imposed by quantum mechanics.Comment: 6 pages, 6 figure

Step-by-step Guideline for disease-specific costing studies in low and middle income countries: a mixed methodology.

__Abstract__ BACKGROUND: Disease-specific costing studies can be used as input into cost-effectiveness analyses and provide important information for efficient resource allocation. However, limited data availability and limited expertise constrain such studies in low- and middle-income countries (LMICs). OBJECTIVE: To describe a step-by-step guideline for conducting disease-specific costing studies in LMICs where data availability is limited and to illustrate how the guideline was applied in a costing study of cardiovascular disease prevention care in rural Nigeria. DESIGN: The step-by-step guideline provides practical recommendations on methods and data requirements for six sequential steps: 1) definition of the study perspective, 2) characterization of the unit of analysis, 3) identification of cost items, 4) measurement of cost items, 5) valuation of cost items, and 6) uncertainty analyses.Please provide the significance of asterisk given in table body. RESULTS: We discuss the necessary tradeoffs between the accuracy of estimates and data availability constraints at each step and illustrate how a mixed methodology of accurate bottom-up micro-costing and more feasible approaches can be used to make optimal use of all available data. An illustrative example from Nigeria is provided. CONCLUSIONS: An innovative, user-friendly guideline for disease-specific costing in LMICs is presented, using a mixed methodology to account for limited data availability. The illustrative example showed that the step-by-step guideline can be used by healthcare professionals in LMICs to conduct feasible and accurate disease-specific cost analyses

Predicting the young’s modulus of defect free radiata pine shooks in finger-jointing using resonance frequency

In this paper, dynamic MOE and static MOE of short-length radiata pine specimens produced for finger jointing were measured using non-destructive technique and correlated to each other. In order to obtain reliable static MOE data, 36 mm thickness shooks as well as the matched samples of reduced thickness (15mm) were tested, and the effect of annual growth rings on dynamic and static MOE is also addressed. Mathematical correlations were fitted between the dynamic MOE for the 36 mm thick shooks and the static MOE of the 15 mm thick samples. The coefficient of determination for dynamic MOE group 4,00-7,99 GPa was the strongest (R2 = 0,82) and the correlation strength was further improved for sorted quarter sawn samples (R2 = 0,92). Finally, the correlation between static modulus of rupture (MOR) and dynamic MOE is discussed