Inside-Out Planet Formation. V. Structure of the Inner Disk as Implied by the MRI

The large population of Earth to super-Earth sized planets found very close to their host stars has motivated consideration of $in$ $situ$ formation models. In particular, Inside-Out Planet Formation is a scenario in which planets coalesce sequentially in the disk, at the local gas pressure maximum near the inner boundary of the dead zone. The pressure maximum arises from a decline in viscosity, going from the active innermost disk (where thermal ionization of alkalis yields high viscosities via the magneto-rotational instability (MRI)) to the adjacent dead zone (where the MRI is quenched). Previous studies of the pressure maximum, based on $\alpha$-disk models, have assumed ad hoc values for the viscosity parameter $\alpha$ in the active zone, ignoring the detailed physics of the MRI. Here we explicitly couple the MRI criteria to the $\alpha$-disk equations, to find steady-state (constant accretion rate) solutions for the disk structure. We consider the effects of both Ohmic and ambipolar resistivities, and find solutions for a range of disk accretion rates ($\dot{M}$ = $10^{-10}$ - $10^{-8}$ ${\rm M}_{\odot}$/yr), stellar masses ($M_{\ast}$ = 0.1 - 1 ${\rm M}_{\odot}$), and fiducial values of the $non$-MRI $\alpha$-viscosity in the dead zone ($\alpha_{\rm {DZ}} = 10^{-5}$ - $10^{-3}$). We find that: (1) A midplane pressure maximum forms radially $outside$ the inner boundary of the dead zone; (2) Hall resistivity dominates near the midplane in the inner disk, which may explain why close-in planets do $not$ form in $\sim$50% of systems; (3) X-ray ionization can be competitive with thermal ionization in the inner disk, because of the low surface density there in steady-state; and (4) our inner disk solutions are viscously unstable to surface density perturbations.Comment: 34 pages, 28 figures, 3 appendices. Accepted by the Astrophysical Journa

Decision-making capacity for treatment in psychiatric and medical in-patients: Cross-sectional, comparative study

BackgroundIs the nature of decision-making capacity (DMC) for treatment significantly different in medical and psychiatric patients?AimsTo compare the abilities relevant to DMC for treatment in medical and psychiatric patients who are able to communicate a treatment choice.MethodA secondary analysis of two cross-sectional studies of consecutive admissions: 125 to a psychiatric hospital and 164 to a medical hospital. The MacArthur Competence Assessment Tool – Treatment and a clinical interview were used to assess decision-making abilities (understanding, appreciating and reasoning) and judgements of DMC. We limited analysis to patients able to express a choice about treatment and stratified the analysis by low and high understanding ability.ResultsMost people scoring low on understanding were judged to lack DMC and there was no difference by hospital (P=0.14). In both hospitals there were patients who were able to understand yet lacked DMC (39% psychiatric v. 13% medical in-patients, P&lt;0.001). Appreciation was a better ‘test’ of DMC in the psychiatric hospital (where psychotic and severe affective disorders predominated) (P&lt;0.001), whereas reasoning was a better test of DMC in the medical hospital (where cognitive impairment was common) (P=0.02).ConclusionsAmong those with good understanding, the appreciation ability had more salience to DMC for treatment in a psychiatric setting and the reasoning ability had more salience in a medical setting.</jats:sec

MRI-active inner regions of protoplanetary discs - II. Dependence on dust, disc, and stellar parameters

Close-in super-Earths are the most abundant exoplanets known. It has been hypothesized that they form in the inner regions of protoplanetary discs, out of the dust that may accumulate at the boundary between the inner region susceptible to the magneto-rotational instability (MRI) and an MRI-dead zone further out. In Paper I, we presented a model for the viscous inner disc which includes heating due to both irradiation and MRI-driven accretion; thermal and non-thermal ionization; dust opacities; and dust effects on ionization. Here, we examine how the inner disc structure varies with stellar, disc, and dust parameters. For high accretion rates and small dust grains, we find that: (1) the main sources of ionization are thermal ionization and thermionic and ion emission; (2) the disc features a hot, high-viscosity inner region, and a local gas pressure maximum at the outer edge of this region (in line with previous studies); and (3) an increase in the dust-to-gas ratio pushes the pressure maximum outwards. Consequently, dust can accumulate in such inner discs without suppressing the MRI, with the amount of accumulation depending on the viscosity in the MRI-dead regions. Conversely, for low accretion rates and large dust grains, there appears to be an additional steady-state solution in which: (1) stellar X-rays become the main source of ionization; (2) MRI-viscosity is high throughout the disc; and (3) the pressure maximum ceases to exist. Hence, if planets form in the inner disc, larger accretion rates (and thus younger discs) are favoured

MRI-active inner regions of protoplanetary discs. I. A detailed model of disc structure

Short-period super-Earth-sized planets are common. Explaining how they form near their present orbits requires understanding the structure of the inner regions of protoplanetary discs. Previous studies have argued that the hot inner protoplanetary disc is unstable to the magneto-rotational instability (MRI) due to thermal ionization of potassium, and that a local gas pressure maximum forms at the outer edge of this MRI-active zone. Here we present a steady-state model for inner discs accreting viscously, primarily due to the MRI. The structure and MRI-viscosity of the inner disc are fully coupled in our model; moreover, we account for many processes omitted in previous such models, including disc heating by both accretion and stellar irradiation, vertical energy transport, realistic dust opacities, dust effects on disc ionization and non-thermal sources of ionization. For a disc around a solar-mass star with a standard gas accretion rate ($\dot{M}$$\sim$$10^{-8}$M$_\odot$yr$^{-1}$) and small dust grains, we find that the inner disc is optically thick, and the accretion heat is primarily released near the midplane. As a result, both the disc midplane temperature and the location of the pressure maximum are only marginally affected by stellar irradiation, and the inner disc is also convectively unstable. As previously suggested, the inner disc is primarily ionized through thermionic and potassium ion emission from dust grains, which, at high temperatures, counteract adsorption of free charges onto grains. Our results show that the location of the pressure maximum is determined by the threshold temperature above which thermionic and ion emission become efficient.Comment: accepted for publication in MNRA

Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses

T-cell-mediated immunity to SARS-CoV-2-derived peptides in individuals unexposed to SARS-CoV-2 has been previously reported. This pre-existing immunity was suggested to largely derive from prior exposure to ‘common cold’ endemic human coronaviruses (HCoVs). To test this, we characterised the sequence homology of SARS-CoV-2-derived T-cell epitopes reported in the literature across the full proteome of the Coronaviridae family. 54.8% of these epitopes had no homology to any of the HCoVs. Further, the proportion of SARS-CoV-2-derived epitopes with any level of sequence homology to the proteins encoded by any of the coronaviruses tested is well-predicted by their alignment-free phylogenetic distance to SARS-CoV-2 (Pearson's r = −0.958). No coronavirus in our dataset showed a significant excess of T-cell epitope homology relative to the proportion of expected random matches, given their genetic similarity to SARS-CoV-2. Our findings suggest that prior exposure to human or animal-associated coronaviruses cannot completely explain the T-cell repertoire in unexposed individuals that recognise SARS-CoV-2 cross-reactive epitopes

Snake Alert Application

In 2008, an estimated 90,000 lives were lost to snake bites, with India being the most devastated [1]. Governments and health agencies spend time and money trying to curb this, but frequently fail because of the dynamic nature of snake threats. Snake Alert is a public health communication application, aiming to provide users assistance in reporting and being notified of snake sightings. First, prevention of snake encounters, by crowd pooling information on snake sightings based on geographical location. Next, the application allows users to upload photos of snakes upon each sighting, and with image recognition, and identifies the respective snake species. Lastly, the application provides onsite instructional self-treatment with specific advice based snake type. This application can be used to save lives, and provide accurate & dynamic information to people living in remote parts of the world

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity

Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed an unexpected phenotype of spinal protrusion in Nkx3.1:Cre;Erk5fl/fl (Erk5fl/fl) mice by ~6–8 weeks of age. X-ray, histological and micro CT (µCT) analyses showed that 100% of male and female Erk5fl/fl mice had a severely deformed curved thoracic spine, with an associated loss of trabecular bone volume. Although sex-specific differences were observed, histomorphometry measurements revealed that both bone resorption and bone formation parameters were increased in male Erk5fl/fl mice compared to wild type (WT) littermates. Osteopenia occurs where the rate of bone resorption exceeds that of bone formation, so we investigated the role of the osteoclast compartment. We found that treatment of RANKL-stimulated primary bone marrow-derived macrophage (BMDM) cultures with small molecule ERK5 pathway inhibitors increased osteoclast numbers. Furthermore, osteoclast numbers and expression of osteoclast marker genes were increased in parallel with reduced Erk5 expression in cultures generated from Erk5fl/fl mice compared to WT mice. Collectively, these results reveal a novel role for Erk5 during bone maturation and homeostasis in vivo

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer

Prostate cancer (CaP) is the most common adult male cancer in the developed world. The paucity of biomarkers to predict prostate tumor biology makes it important to identify key pathways that confer poor prognosis and guide potential targeted therapy. Using a murine forward mutagenesis screen in a Pten-null background, we identified peroxisome proliferator-activated receptor gamma (Pparg), encoding a ligand-activated transcription factor, as a promoter of metastatic CaP through activation of lipid signaling pathways, including up-regulation of lipid synthesis enzymes [fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY)]. Importantly, inhibition of PPARG suppressed tumor growth in vivo, with down-regulation of the lipid synthesis program. We show that elevated levels of PPARG strongly correlate with elevation of FASN in human CaP and that high levels of PPARG/FASN and PI3K/pAKT pathway activation confer a poor prognosis. These data suggest that CaP patients could be stratified in terms of PPARG/FASN and PTEN levels to identify patients with aggressive CaP who may respond favorably to PPARG/FASN inhibition