The relationship between serum albumin levels and 24-h ambulatory blood pressure monitoring recordings in non-diabetic essential hypertensive patients

OBJECTIVES: The goal of this study was to evaluate the relationship between serum albumin levels and 24-hour ambulatory blood pressure monitoring (24-h ABPM) recordings in non-diabetic essential hypertensive patients. METHODS: A total of 354 patients (mean [SD] age: 55.5 [14.3] years, 50% females) with essential hypertension and 24-h ABPM recordings were included. Patient 24-h nighttime and daytime ABPM values, systolic and diastolic dipping status and average nocturnal dipping were recorded. The correlations between serum albumin levels and nocturnal systolic and diastolic dipping were evaluated, and correlates of average nocturnal systolic dipping were determined via a linear regression model. RESULTS: Overall, 73.2% of patients were determined to be non-dippers. The mean (SD) levels of serum albumin (4.2 [0.3] g/dL vs. 4.4 [0.4] g/dL,

THE PREDICTIVE VALUE OF MALNUTRITION - INFLAMMATION SCORE ON 1 YEAR MORTALITY IN MAINTENANCE HEMODIALYSIS PATIENTS

53rd ERA-EDTA Congress -- MAY 21-24, 2016 -- Vienna, AUSTRIASahutoglu, Tuncay/0000-0003-2015-4421WOS: 000376653802454[No abstract available]European Renal Assoc, European Dialysis & Transplant Asso

Persistent left superior vena cava: Two case reports and a review from nephrologists' perspective

Sahutoglu, Tuncay/0000-0003-2015-4421; sevinc, mustafa/0000-0003-2804-4884; Hasbal, Nuri Baris/0000-0002-2229-5140WOS: 000379825800009PubMed: 26843030Thoracic venous anomalies without congenital heart anomalies are present in minority of the population, but they are frequent enough to be encountered while placing hemodialysis catheters through the jugular or subclavian veins. Persistent left superior vena cava is the most commonly seen anomaly and it is rarely noticed before the observation of an unusual course of hemodialysis catheter or guidewire on chest X-ray. We present two patients with previously unspotted persistent left superior vena cava and uncomplicated hemodialysis catheter insertions through the internal jugular veins with good catheter functions. Review of the relevant literature from a nephrologists' perspective with technical aspects is provided

The predictive value of malnutrition - inflammation score on 1-year mortality in Turkish maintenance hemodialysis patients

Sahutoglu, Tuncay/0000-0003-2015-4421; sevinc, mustafa/0000-0003-2804-4884WOS: 000384940700006PubMed: 27345184Objective: the aim of this study was to evaluate the predictive value of malnutrition-inflammation score (MIS) on short-term mortality and to identify the best cut-off point in the Turkish maintenance hemodialysis (MHD) population. Methods: A total of 100 patients on MHD were included in this prospective single-center study. Demographic, anthropometric, and biochemical data were obtained from all patients. the study population was followed up as a 12-month prospective cohort to evaluate mortality as the primary outcome. Results: Median (IQR) age and HD vintage of 100 patients (M/F: 52/48) were 53 (39.5 - 67) years and 53.5 (11 - 104.7) months, respectively. Deceased patients (n = 7) had significantly older age (years) (50 (38.5 - 63.5) vs. 70 (62 - 82), respectively, p = 0.001), lower spKt/V (1.60 (1.40 - 1.79) vs. 1.35 (0.90 - 1.50), respectively, p = 0.002), lower triceps skinfold thickness (14 (10 - 19) vs. 9 (7 - 11), respectively, p = 0.021) and higher MIS (5 (4 - 7) vs. 10 (7 - 11), respectively, p = 0.013). in the ROC analysis, we found that the optimal cut-off value of MIS for predicting death was 6.5 with 85.7% sensitivity and 62.4% specificity (positive and negative predictive values were 0.6951 and 0.8136, respectively). Advanced age, low spKt/V, and high MIS were found to be predictors of mortality in multivariate logistic regression analysis. the 1-year mortality rate was significantly higher in MIS > 6.5 group compared to the MIS 6.5 was found to be significantly lower (47.8 +/- 0.16 vs. 43.6 +/- 1.63 weeks, respectively, p (log-rank) = 0.012). Conclusion: MIS is a robust and independent predictor of short-term mortality in MHD patients. Patients with MIS > 6.5 had a significant risk, and additional risk factors associated with short-term mortality were advanced age and low spKt/V

The effects of angiotensin-converting enzyme inhibitors on peritoneal protein loss and solute transport in peritoneal dialysis patients

OBJECTIVE: The objective of this study was to examine the effects of angiotensin-converting enzyme inhibitors on peritoneal membrane transport, peritoneal protein loss, and proteinuria in peritoneal dialysis patients. METHODS: Fifty-four peritoneal dialysis patients were included in the study. The patients were divided into two groups. Group 1 (n = 34) was treated with angiotensin-converting enzyme inhibitors. Group 2 (n = 20) did not receive any antihypertensive drugs during the entire follow-up. Eleven patients were excluded from the study thereafter. Thus, a total of 30 patients in Group 1 and 13 patients in Group 2 completed the study. We observed the patients for six months. Group 1 patients received maximal doses of angiotensin-converting enzyme inhibitors for six months. Parameters at the beginning of study and at the end of six months were evaluated. RESULTS: At the end of six months, total peritoneal protein loss in 24-hour dialysate effluent was significantly decreased in Group 1, whereas it was increased in Group 2. Compared to the baseline level, peritoneal albumin loss in 24-hour dialysate effluent and 4-hour D/P creatinine were significantly increased in Group 2 but were not significantly changed in Group 1. A covariance analysis between the groups revealed a significant difference only in the decreased amount of total protein loss in 24-hour dialysate. Proteinuria was decreased significantly in Group 1. CONCLUSION: This study suggests that angiotensin-converting enzyme inhibitors reduce peritoneal protein loss and small-solute transport and effectively protect peritoneal membrane transport in peritoneal dialysis patients

Air embolism following removal of hemodialysis catheter

sevinc, mustafa/0000-0003-2804-4884; Sahutoglu, Tuncay/0000-0003-2015-4421; Hasbal, Nuri Baris/0000-0002-2229-5140WOS: 000393616400009PubMed: 27457403Introduction: Air embolism (AE) is a rare, but serious complication that can occur in the practice of hemodialysis. in contrast to careful techniques andmeticulous care during insertions and manipulations of the central catheters, awareness of the risk of AE following catheter removal is less. We aimed to analyze the clinical characteristics of the all case reports with AE after catheter removal and summarize the mechanisms, clinical consequences, treatment and prevention of AE. Methods: in addition to our case, MEDLINE database was searched for all case reports with AE following catheter removal, and the clinical, diagnostic and outcome data were analyzed. Findings: A total of 10 patients (including our case) (M/F 6/4; median age 50.5 years) were found for the analysis. Procedures for prevention of AE were reported in a few patients (Trendelenburg position 2, airtight dressing 1). the time that elapsed between catheter removals and onset of AEs was ranged from seconds to 6 hours. the most common findings were dyspnea (90%), hypoxemia (70%), and cerebral dysfunction (70%). the most common sites where air could be detected were the left ventricle (40%), pulmonary artery (30%) and right ventricle (30%). Mortality was reported in 4 (40%) cases and the remaining 6 patients had complete recovery. Blocking of air portal was not reported in any of the fatal cases. Discussion: AE following catheter removal carries a major risk of mortality. Great awareness and attention to preventive procedures and appropriate care after development of AE seemmandatory

FGF-23 associated with the progression of coronary artery calcification in hemodialysis patients

Background: Disordered mineral metabolism is implicated in the pathogenesis of vascular calcification in hemodialysis (HD) patients. Fibroblast growth factor 23 (FGF-23) is the main regulator of phosphate metabolism. In this prospective study, we aimed to investigate the association of serum FGF-23 with progression of coronary artery calcification in HD patients

IMPACT OF DELIVERED DIALYSIS DOSE ON 1 YEAR MORTALITY OF NONDIABETIC MAINTENANCE HEMODIALYSIS PATIENTS

53rd ERA-EDTA Congress -- MAY 21-24, 2016 -- Vienna, AUSTRIASahutoglu, Tuncay/0000-0003-2015-4421WOS: 000376653802389[No abstract available]European Renal Assoc, European Dialysis & Transplant Asso