Pengaruh Media Prezi terhadap Hasil Belajar Peserta Didik pada Materi Sistem Pencernaan pada Manusia (Studi Eksperimen di Kelas VIII SMP Negeri 20 Kota Tasikmalaya, Tahun Ajaran 2018/2019)

Tujuan penelitian ini adalah untuk mengetahui pengaruh Media Pembelajaran Prezi jika diterapkan pada proses pembelajaran mengenai materi sistem pencernaan manusia di kelas VIII SMP Negeri 20 Kota Tasikmalaya. Penelitian ini dilaksanakan pada bulan April 2018 sampai dengan bulan Agustus 2018 di kelas VIII SMP Negeri 20 Tasikmalaya. Metode penelitian yang digunakan adalah metode true eksperimental. Populasi dalam penelitian ini seluruh peserta didik kelas VIII SMP Negeri 20 Kota Tasikmalaya sebanyak 9 kelas, dengan jumlah 273 orang. Sampel diambil dengan menggunakan teknik cluster random sampling sebanyak 2 kelas. Instrumen yang digunakan adalah teknik tes hasil belajar peserta didik pada materi sistem pencernaan manusia. Tes tertulis ini berupa pilihan ganda dengan empat option. Teknik analisis data yang digunakan adalah uji t dengan α = 0,05. Berdasarkan hasil penelitian, analisis data dan pengujian hipotesis didapatkan nilai t­hitung = -20,48 dan ttabel =2,04. Maka thitung terletak di daerah penolakan Ho, hal tersebut menunjukan bahwa ada pengaruh hasil belajar peserta didik yang proses pembelajarannya menggunakan media prezi pada materi sistem pencernaan manusia di kelas VIII SMP Negeri 20 Kota Tasikmalaya tahun ajaran 2018/2019

Exploring Perceptions of Goodness Among the Malaysian and Chinese University Students: A Focus Group Study

The notion of goodness is implicitly central to the discourse relating to person perception. To date, no empirical research has focused solely upon understanding the notion of goodness and how it’s perceived and discerned in others. Utilizing focus group interviews, this paper explores how people perceive and interpret goodness in collectivist cultures of Malaysia and China. Findings revealed that Malaysian and Chinese participants had somewhat similar notions about goodness. “Concern for others’ welfare” was found to have the most resonance across the two nationalities as a key element in discerning goodness in others. Another category emerging from the findings was labelled as “Goodness a subjective notion” which encapsulated additional interpretations surrounding goodness. Directions for future research are discussed

The EHA Research Roadmap:Platelet Disorders

In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the diagnostics and treatment of blood disorders, and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. Each section was coordinated by 1 to 2 section editors who were leading international experts in the field. In the 5 years that have followed, advances in the field of hematology have been plentiful. As such, EHA is pleased to present an updated Research Roadmap, now including 11 sections, each of which will be published separately. The updated EHA Research Roadmap identifies the most urgent priorities in hematology research and clinical science, therefore supporting a more informed, focused, and ideally a more funded future for European hematology research. The 11 EHA Research Roadmap sections include Normal Hematopoiesis; Malignant Lymphoid Diseases; Malignant Myeloid Diseases; Anemias and Related Diseases; Platelet Disorders; Blood Coagulation and Hemostatic Disorders; Transfusion Medicine; Infections in Hematology; Hematopoietic Stem Cell Transplantation; CAR-T and Other Cellbased Immune Therapies; and Gene Therapy

Phenethyisoquinoline alkaloids from the leaves of Androcymbium palaestinum

Thirteen compounds were isolated from the methanolic extract of the leaves of Androcymbium palaestinum Baker (Colchicaceae). Of these, three were new, two were new natural products, and eight were known. The new isolated compounds were (+)-1-demethylandrocine (5), (−)-andropalaestine (8), and (+)-2-demethyl-β-lumicolchicone (10), while the new natural products were (+)-O-methylkreysigine-N-oxide (3) and (+)-O,O-dimethylautumnaline (9). Moreover, two known compounds are reported for the first time from this species, specifically (−)-colchicine (11) and (−)-3-demethyldemecolcine (13). The structures of the isolated compounds were elucidated using a series of spectroscopic and spectrometric techniques, principally HRESIMS, 1D-NMR (1H and 13C NMR) and 2D-NMR (COSY, edited-HSQC, and HMBC). ECD spectroscopy was used for assigning the absolute configurations of compounds 3, 5, and 10. The cytotoxic activities of the isolated compounds were evaluated using the MDA-MB-435 (melanoma), MDA-MB-231 (breast), and OVCAR3 (ovary) cancer cell lines. Compound 11 was the most potent against all tested cell lines, with IC50 values of 12, 95 and 23 nM, respectively.This research was supported, in part, by the Deanship of Research, Jordan University of Science and Technology, Irbid, Jordan (Grant No. 258/2017) and the National Cancer Institute/National Institutes of Health, Bethesda, MD, USA via P01 CA125066. We thank Dr. L. Flores Bocanegra, J. M. Gallagher, Z. Y. Al Subeh, and Dr. N. D. Paguigan from UNCG for technical help and valuable suggestions. This work was performed in part at the Joint School of Nanoscience and Nanoengineering, a member of the Southeastern Nanotechnology Infrastructure Corridor (SENIC) and National Nanotechnology Coordinated Infrastructure (NNCI), which is supported by the National Science Foundation (Grant ECCS-1542174)

Acute post-exercise energy and macronutrient intake in lean and obese youth: a systematic review and meta-analysis

Aim: This review aims to determine if acute exercise affects subsequent energy and macronutrients intake in obese and non-obese children and adolescents. Methods: Databases were searched between January 2015 and December 2015 for studies reporting energy and/or macronutrients intake immediately after an acute exercise and control condition, in children and adolescents. From the initial 118 references found, 14 were included for subsequent analysis after screening representing 31 acute exercise conditions that varied in intensity, duration and modality. Results: One study found increased energy intake after exercise, seven decreased and 23 revealed no change. The meta-analysis revealed a significant effect of acute exercise on intake in obese but not in lean youth by a mean difference of −0.430 (95% confidence interval=−0.703 to −0.157, P=0.002) displaying low heterogeneity (I2=0.000; Q=5.875; df=9, P=0.752). The analysis showed that intense exercise only reduces intake in obese children (no intensity effect in lean). Unchanged macronutrients intake was reported in nine studies as opposed to three which found modified lipids, protein and/or carbohydrate intake. Conclusion: Although acute exercise does not affect energy intake in lean, it appears to reduced food intake in obese youth when intense, without altering the macronutrients composition of the meal

IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling

The prognosis of chronic lymphocytic leukemia (CLL) depends on different markers, including cytogenetic aberrations, oncogenic mutations, and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene. The number of IGHV mutations distinguishes mutated (M) CLL with a markedly superior prognosis from unmutated (UM) CLL cases. In addition, B cell antigen receptor (BCR) stereotypes as defined by IGHV usage and complementarity-determining regions (CDRs) classify ∼30% of CLL cases into prognostically important subsets. Subset 2 expresses a BCR with the combination of IGHV3-21-derived heavy chains (HCs) with IGLV3-21-derived light chains (LCs), and is associated with an unfavorable prognosis. Importantly, the subset 2 LC carries a single-point mutation, termed R110, at the junction between the variable and constant LC regions. By analyzing 4 independent clinical cohorts through BCR sequencing and by immunophenotyping with antibodies specifically recognizing wild-type IGLV3-21 and R110-mutated IGLV3-21 (IGLV3-21R110), we show that IGLV3-21R110-expressing CLL represents a distinct subset with poor prognosis independent of IGHV mutations. Compared with other alleles, only IGLV3-21*01 facilitates effective homotypic BCR-BCR interaction that results in autonomous, oncogenic BCR signaling after acquiring R110 as a single-point mutation. Presumably, this mutation acts as a standalone driver that transforms IGLV3-21*01-expressing B cells to develop CLL. Thus, we propose to expand the conventional definition of CLL subset 2 to subset 2L by including all IGLV3-21R110-expressing CLL cases regardless of IGHV mutational status. Moreover, the generation of monoclonal antibodies recognizing IGLV3-21 or mutated IGLV3-21R110 facilitates the recognition of B cells carrying this mutation in CLL patients or healthy donors

Density Distribution in the Liquid Hg-Sapphire Interface

We present the results of a computer simulation study of the liquid density distribution normal to the interface between liquid Hg and the reconstructed (0001) face of sapphire. The simulations are based on an extension of the self-consistent quantum Monte Carlo scheme previously used to study the structure of the liquid metal-vapor interface. The calculated density distribution is in very good agreement with that inferred from the recent experimental data of Tamam et al (J. Phys. Chem. Lett. 1, 1041-1045 (2010)). We conclude that, to account for the difference in structure between the liquid Hg-vapor and liquid-Hg-reconstructed (0001) Al2O3 interfaces, it is not necessary assume there is charge transfer from the Hg to the Al2O3. Rather, the available experimental data are adequately reproduced when the van der Waals interactions of the Al and O atoms with Hg atoms and the exclusion of electron density from Al2O3 via repulsion of the electrons from the closed shells of the ions in the solid are accounted for.Comment: 26 pages, 11 figure