Penetrative nature of high energy showers observed in Chacaltaya emulsion chamber

About 30% of single core showers with E (sup gamma) 10 TeV have stronger penetrating power than that expected from electromagnetic showers (e,gamma). On the other hand, their starting points of cascades in the chamber are found to be as shallow as those of (e,gamma) components. It is suggested that those showers are very collimated bundles of hadron and (e,gamma) component. Otherwise, it is assumed that the collision mean free path of those showers in the chamber is shorter than that of hadron with geometrical value

Effects of annealing time on structural and magnetic properties of L10-FePt nanoparticles synthesized by the SiO2-nanoreactor method

We investigated effects of annealing time on structural and magnetic properties of the L10-FePt nanoparticles synthesized by the SiO2-nanoreacter method. The magnetization and powder X-ray diffraction studies revealed that the annealing at 900 oC for 9 hr could convert all of the fcc-nanoparticles to the well-crystallized L10 structure with a large coercivity while keeping their particle size. Such monodisperse and highly crystalline L10-FePt nanoparticles are a promising material for the realization of ultra-high density recording.Comment: 9 pages, 2 figure

Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease

BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in chronic obstructive pulmonary disease (COPD). A large population of patients with COPD also have pulmonary hypertension. Krüppel-like factor 5 (KLF5) is a zinc-finger transcription factor that contributes to tissue remodeling in cardiovascular diseases. Here, we evaluate the possible involvement of KLF5 in the remodeling of small airways and pulmonary vessels in COPD. METHODS: Lung tissues were obtained from 23 control never-smokers, 17 control ex-smokers and 24 ex-smokers with COPD. The expression of KLF5 in the lung tissues was investigated by immunohistochemistry. We investigated whether oxidative/nitrosative stress, which is a major cause of the pathogenesis in COPD, could augment the production of KLF5. We examined the role of KLF5 in the stress-mediated tissue remodeling responses. We also investigated the susceptibility of KLF5 expression to nitrosative stress using bronchial fibroblasts isolated from the lung tissues. RESULTS: The expression of KLF5 was up-regulated in the small airways and pulmonary vessels of the COPD patients and it was mainly expressed in bronchial fibroblasts and cells of the pulmonary vessels. The extent of the KLF5 expression in the small airway of the COPD group had a significant correlation with the severity of the airflow limitation. Oxidative/nitrosative stress augmented the production of KLF5 in lung fibroblasts as well as the translocation of KLF5 into the nuclei. Silencing of KLF5 suppressed the stress-augmented differentiation into myofibroblasts, the release of collagens and metalloproteinases. Bronchial fibroblasts from the patients with COPD highly expressed KLF5 compared to those from the control subjects under basal condition and were more susceptible to the induction of KLF5 expression by nitrosative stress compared to those from the control subjects. CONCLUSION: We provide the first evidence that the expression of KLF5 is up-regulated in small airways and pulmonary vessels of patients with COPD and may be involved in the tissue remodeling of COPD

Inelasticity Distribution Of Hadron-pb Collisions In The Energy Region Exceeding 1014 Ev From Mountain Cosmic Ray Experiments

The inelasticity distribution of hadron-lead collisions in the energy region exceeding 1014 eV is estimated on the basis of 66 events, induced by cosmic ray hadrons and detected at high mountain altitudes at Pamir (4300 m, 595 g/cm2). The distribution of the best fitting is approximated as g(K)dK=[α(1-K)m1-1 + βKm2-1]dK, where m1=0.5, m2=1.125, α=0.26, β=0.55, giving 〈K〉=0.60. The errors of the parameters are discussed in the text. The distribution is compared with those which are based on theoretical models. ©1999 The American Physical Society.611110Frichter, G.M., Gaisser, T.K., Stanev, T., (1997) Phys. Rev. D, 56, p. 3135Fowler, G.N., Weiner, R.M., Wilk, G., (1985) Phys. Rev. Lett., 55, p. 173Fowler, G.N., Vourdas, A., Weiner, R.M., Wilk, G., (1987) Phys. Rev. D, 35, p. 870Fowler, G.N., Navarra, F.S., Plümer, M., Voudras, A., Weiner, R.M., Wilk, G., (1989) Phys. Rev. C, 40, p. 1219Shabelski, Yu.M., Weiner, R.M., Wilk, G., Włodarczyk, Z., (1992) J. Phys. G, 18, p. 1281Włodarczyk, Z., (1995) J. Phys. G, 21, p. 281Chou, T.T., Yang, C.N., (1985) Phys. Rev. D, 32, p. 1692Gaisser, T.K., Stanev, T., (1989) Phys. Lett. B, 219, p. 375Kaǐdalov, A.B., Ter-Martirosyan, K.A., (1987) Proceedings of the 20th International Cosmic Ray Conference, 5, p. 139(1984) Sov. J. Nucl. Phys., 40, p. 135Nazareth, R.A.M.S., Kodama, T., Portes Jr., D.A., (1992) Phys. Rev. D, 46, p. 2896Schatz, G., Thouw, T., Werner, K., Oehlschläger, J., Bekk, K., (1994) J. Phys. G, 20, p. 1267Gaisser, T.K., Protheroe, R.J., Turver, K.E., McComb, T.J.L., (1978) Rev. Mod. Phys., 50, p. 859Van Hove, L., Pokorski, S., (1975) Nucl. Phys., B86, p. 243Akashi, M., (1964) Prog. Theor. Phys. Suppl., 32, p. 1Feynman, R., (1969) Phys. Rev. Lett., 23, p. 1415Taylor, F.E., Carey, D.C., Johnson, J.R., Kammerud, R., Ritchie, D.J., Roberts, A., Sauer, J.R., Walker, J.K., (1976) Phys. Rev. D, 14, p. 1217Ohsawa, A., (1994) Prog. Theor. Phys., 92, p. 1005Arata, N., (1983) Nucl. Phys., B211, p. 189Tabuki, T., (1983) Prog. Theor. Phys. Suppl., 76, p. 40Chinellato, J.A., (1983) Prog. Theor. Phys. Suppl., 76, p. 1Alner, G.L., (1987) Phys. Rep., 5-6, p. 247Nishimura, J., (1967) Handbuch der Physik, 46 (2), p. 1. , Springer, BerlinArisawa, T., Fujimoto, Y., Hasegawa, S., Honda, K., Ito, H., Kopenkin, V.V., Semba, H., Strogova, O.P., (1994) Nucl. Phys., B424, p. 241Baradzei, L.T., (1992) Nucl. Phys. B, B370, p. 365Kopenkin, V., Fujimoto, Y., (1996) Nuovo Cimento C, 19, p. 1017Moriya, M., (1997), Master thesis, Waseda UniversityBarroso, S.L.C., Fujimoto, Y., Kopenkin, V., Moriya, M., Navia, C., Ohsawa, A., Shibuya, E.H., Tamada, M., (1997) Nucl. Phys. B (Proc. Suppl.), 52 B, p. 201(1997) Proceedings of the 25th International Cosmic Ray Conference, 6, p. 41Hama, Y., Paiva, S., (1997) Phys. Rev. Lett., 78, p. 3070Tamada, M., (1995) J. Phys. G, 21, p. 1387Knapp, J., Heck, D., Schatz, G., (1996) Report of Institut für Kernphysik, Forschungszentrum Karlsruhe, , Wissenchafteliche Berichte FZKA 5828Harr, R., Liapis, C., Karchin, P., Biino, C., Erhan, S., Hofmann, W., Kreuzer, P., Zweizig, J., (1997) Phys. Lett. B, 401, p. 176Tamada, M., Kopenkin, V.V., (1997) Nucl. Phys., B494, p. 3Ohsawa, A., (1971) Prog. Theor. Phys. Suppl., 47, p. 180Gaisser, T.K., (1990) Cosmic Rays and Particle Physics, , Cambridge University Press, Cambridge, Englan

Production of scFv-Conjugated Affinity Silk Powder by Transgenic Silkworm Technology

Bombyx mori (silkworm) silk proteins are being utilized as unique biomaterials for medical applications. Chemical modification or post-conjugation of bioactive ligands expand the applicability of silk proteins; however, the processes are elaborate and costly. In this study, we used transgenic silkworm technology to develop single-chain variable fragment (scFv)-conjugated silk fibroin. The cocoons of the transgenic silkworm contain fibroin L-chain linked with scFv as a fusion protein. After dissolving the cocoons in lithium bromide, the silk solution was dialyzed, concentrated, freeze-dried, and crushed into powder. Immunoprecipitation analyses demonstrate that the scFv domain retains its specific binding activity to the target molecule after multiple processing steps. These results strongly suggest the promise of scFv-conjugated silk fibroin as an alternative affinity reagent, which can be manufactured using transgenic silkworm technology at lower cost than traditional affinity carriers

LIGHT Induces Distinct Signals to Clear an AAV-Expressed Persistent Antigen in the Mouse Liver and to Induce Liver Inflammation

Background: Infection with adeno-associated virus (AAV) vector with liver tropism leads to persistent expression of foreign antigens in the mouse liver, with no significant liver inflammation or pathology. This provides a model to investigate antigen persistence in the liver and strategies to modulate host immunity to reduce or clear the foreign antigen expressed from AAV vector in the liver. Methods/Principal Findings: We showed that expressing LIGHT with an adenovirus vector (Ad) in mice with established AAV in the liver led to clearance of the AAV. Ad-LIGHT enhanced CD8 effector T cells in the liver, correlated with liver inflammation. LTbR-Ig proteins blocked Ad-LIGHT in clearing AAV. Interestingly, in LTbR-null mice, Ad-LIGHT still cleared AAV but caused no significant liver inflammation. Conclusions/Significance: Our data suggest that LIGHT interaction with the LTbR plays a critical role in liver inflammation but is not required for LIGHT-mediated AAV clearance. These findings will shed light on developing novel immunotherapeutic

Extreme Nature of Four Blue-excess Dust-obscured Galaxies Revealed by Optical Spectroscopy

We report optical spectroscopic observations of four blue-excess dust-obscured galaxies (BluDOGs) identified by the Subaru Hyper Suprime-Cam. BluDOGs are a subclass of dust-obscured galaxies (DOGs; defined with the extremely red color (i − [22])AB ≥ 7.0; Toba et al., showing a significant flux excess in the optical g and r bands over the power-law fits to the fluxes at the longer wavelengths. Noboriguchi et al. have suggested that BluDOGs may correspond to the blowing-out phase involved in a gas-rich major-merger scenario. However, the detailed properties of BluDOGs are not understood because of the lack of spectroscopic information. In this work, we carry out deep optical spectroscopic observations of four BluDOGs using Subaru/FOCAS and VLT/FORS2. The obtained spectra show broad emission lines with extremely large equivalent widths, and a blue wing in the C iv line profile. The redshifts are between 2.2 and 3.3. The averaged rest-frame equivalent widths of the C iv lines are 160 \ub1 33 \uc5, ∼7 times higher than the average of a typical type 1 quasar. The FWHMs of their velocity profiles are between 1990 and 4470 km s−1, and their asymmetric parameters are 0.05 and 0.25. Such strong C iv lines significantly affect the broadband magnitudes, which are partly the origin of the blue excess seen in the spectral energy distribution of BluDOGs. Their estimated supermassive black hole masses are 1.1 7 108 < M BH/M ⊙ <5.5 7 108. The inferred Eddington ratios of the BluDOGs are higher than 1 (1.1 < λ Edd < 3.8), suggesting that the BluDOGs are in a rapidly evolving phase of supermassive black holes

Possible origins of macroscopic left-right asymmetry in organisms

I consider the microscopic mechanisms by which a particular left-right (L/R) asymmetry is generated at the organism level from the microscopic handedness of cytoskeletal molecules. In light of a fundamental symmetry principle, the typical pattern-formation mechanisms of diffusion plus regulation cannot implement the "right-hand rule"; at the microscopic level, the cell's cytoskeleton of chiral filaments seems always to be involved, usually in collective states driven by polymerization forces or molecular motors. It seems particularly easy for handedness to emerge in a shear or rotation in the background of an effectively two-dimensional system, such as the cell membrane or a layer of cells, as this requires no pre-existing axis apart from the layer normal. I detail a scenario involving actin/myosin layers in snails and in C. elegans, and also one about the microtubule layer in plant cells. I also survey the other examples that I am aware of, such as the emergence of handedness such as the emergence of handedness in neurons, in eukaryote cell motility, and in non-flagellated bacteria.Comment: 42 pages, 6 figures, resubmitted to J. Stat. Phys. special issue. Major rewrite, rearranged sections/subsections, new Fig 3 + 6, new physics in Sec 2.4 and 3.4.1, added Sec 5 and subsections of Sec