Accelerator production of tritium 700 MHz and 350 MHz klystron test results

The Accelerator Production of Tritium project (APT) utilizes a 1,700 MeV, 100 mA proton Linac. The radio frequency (RF) power is provided by 244 continuous wave (CW) klystron amplifiers at 350 MHz and 700 MHz. All but three of the klystrons operate at a frequency of 700 MHz. The 350 MHz klystrons have a nominal output power of 1.2 MW at a DC-to-RF conversion efficiency of 65%. They are modulating-anode klystrons and operate at a beam voltage and current of 95 kV and 20 A. The design is based on the CERN klystron. The 700 MHz klystron is a new development for APT. Three 700 MHz klystrons are currently under development. Two vendors are each developing a baseline klystron that has a nominal output power of 1.0 MW at a DC-to-RF conversion efficiency of 65%. A 700 MHz klystron is also under development that promises to provide an efficiency in excess of 70%. The 700 MHz klystrons operate at a maximum beam voltage of 95 kV and a maximum beam current of 17 A. The test results of these klystrons will be presented and the design features will be discussed

rf modulator design and phase amplitude control for a high-power free-electron-laser linac

The continued interest for building tunable lasers using an electron accelerator as the source of primary energy has resulted in the design of a new accelerator. Earlier work by other members of the Los Alamos team has demonstrated that this design does work in an amplifier mode. The accelerator is to be upgraded for use in an oscillator experiment and the new rf power amplifier system must meet some of the very stringent demands for power and stability placed on the electron beam for the free-electron laser (FEL) interaction to be observed. These demands are particularly stringent because the electron beam energy ultimately will be circulated back through the accelerator so that the electron beam energy not used in the FEL interaction is not wasted. These considerations have to some measure been incorporated into the design of the second FEL system at Los Alamos and are discussed

The RF system for the National Spallation Neutron Source linac

The National Spallation Neutron Source (NSNS) system has been proposed to dramatically improve the neutron capabilities for science applications in the US. The NSNS is a fast pulse neutron source that would consist of a 1000 MeV H-linac, an accumulator ring, a neutron target, and an experimental area. Although the NSNS is to be built at Oak Ridge, the design responsibility is delegated to five US national laboratories, and the Los Alamos National Laboratory is responsible for the linac portion of this machine, from the output of the radio frequency quadrupole (RFQ) accelerator, to the entrance to the accumulator ring. In the baseline design, a total of 59 klystrons are used to provide the RF power for a 1-MW average power beam in the accumulator ring, and a 1.04 ms pulse length, 6.24% duty factor beam in the linac. The frequencies chosen are 402.5 MHz for the RFQ and drift tube linac (DTL) portions of the machine, and 805 MHz for the coupled-cavity DTL (CCDTL) and coupled cavity (CCL) portions of the linac. The baseline 805 MHz klystron is capable of 2.5 MW peak power into a flat load, and it contains a modulating anode. The backup 805 MHz klystron is cathode pulsed, and has a 5 MW peak output power. The modulators for these two klystrons are vastly different. The challenges and compromises for the two klystrons and their associated modulators and RF systems are discussed. The baseline design RF system is presented in detail

The RF system for the Accelerator Production of Tritium (APT) Low Energy Demonstration Accelerator (LEDA) at Los Alamos

To develop and demonstrate the crucial front end of the APT accelerator and some of the critical components for APT, Los Alamos is building a CW proton accelerator (LEDA) to provide 100 mA at up to 40 MeV. LEDA will be installed where the SDI-sponsored Ground Test Accelerator was located. The first accelerating structure for LEDA is a 7-MeV RFQ operating at 350 MHz, followed by several stages of a coupled-cavity Drift Tube Linac (CCDTL) operating at 700 MHz. The first stage of LEDA will go to 12 MeV. Higher energies, up to 40 MeV, come later in the program. Three 1.2-MW CW RF systems will be used to power the RFQ. This paper describes the RF systems being assembled for LEDA, including the 350 and 700-MHz klystrons, the High Voltage Power Supplies, transmitters, RF transport, window/coupler assemblies, and controls. Some of the limitations imposed by the schedule and the building itself are addressed

Effects of Music Therapy On Hospitalized Patients with Severe Mental Illnesses

Previous studies reported that music therapy (MT) exerts a positive effect on many medical and neuropsychiatric disorders. The use of MT has been proposed also for patients with severe mental illnesse (SMI), altrough further studies are still needed. The aim of the present study was to evaluate the effects on a structured MT program on clinical and social functioning indices of patient with SMI, hospitalized in an psychiatric emergency ward. The MT intervention followed the Benenzon model of MT and was delivered biweekly to 61 patients consecutively admittted to the psychiatric emergency ward. Subjects who did not complete the two-week MT intervention (N=45) were considered as the control group. all subjects were administred the Brief Psychiatric Rating Scale (BPRS) to evaluate the general psychopatology, the Hospital Anxiety And Depression Scale (HADS) for affective symptomatology, the Clinical Global Impression Scale (CGI-S) for severity of symptoms and the Global Assestment of Functioning (GAF) for psychosocial functioning. A repeated measures analysis of variance revealed that patients who unerwent the MT intervention had a statistically significant reduction of general and affective psychopatology scores and of symptoms severity with respect to the control group, after observation period. Our result are in line with previous studies confirming that MT may exert positive effects on psychopatology (in particular, on affective symptomatology) of patient with SMI, and extend this observation to an emergency setting, with short period of hospital stay

The SNS linac high power RF system design, status, and results

The Spallation Neutron Source being built at the Oak Ridge National Lab in Tennessee requires a 1 GeV proton linac. Los Alamos has responsibility for the RF systems for the entire linac. The linac requires 3 distinct types of RF systems: 2.5-MW peak, 402.5 MHz, RF systems for the RFQ and DTL (7 systems total); 5-MW peak, 805 MHz systems for the CCL and the two energy corrector cavities (6 systems total); and 550-kW peak, 805 MHz systems for the superconducting sections (8 1 systems total). The design of the SNS Linac RF system was presented at the 2001 Particle Accelerator Conference in Chicago. Vendors have been selected for the klystrons (3 different vendors), circulators ( I vendor), transmitter (1 vendor), and high power RF loads (3 different vendors). This paper presents the results and status of vendor procurements, test results of the major components of the Linac RF system and our installation progress

Comparison of efavirenz levels in blood and hair with pharmacy refills as measures of adherence and predictors of viral suppression among people living with HIV in Nigeria

BackgroundStrategies to support adherence are constrained by the lack of tools to objectively monitor medication intake in low-resource settings. Pharmacologic measures are objective, but pharmacy refill data is more accessible and cost-efficient. This study compared short-term and long-term efavirenz (EFV) drug levels with pharmacy refill adherence data (PRA) and evaluated their ability to predict viral suppression among people living with HIV in Nigeria.MethodsPaired hair and dried blood spot (DBS) samples were obtained from 91 adults living with HIV receiving 600 mg EFV-based antiretroviral therapy (ART) and EFV concentrations were measured via validated methods using liquid-chromatography-mass-spectrometry. PRA was estimated from pharmacy records, based on the number of days a patient collected medication before or after the scheduled pick-up date. PRA was categorized into ≤ 74%, 75-94% and ≥ 95%, defined as poor, medium and high adherence, respectively. HIV viral loads closest to the hair sampling time (within 6 months) were also abstracted. Receiver Operating Characteristics (ROC) curve analyses compared the ability of adherence metrics to predict viral suppression.ResultsBased on PRA, 81% of participants had high adherence while 11% and 8% had medium and poor adherence, respectively. The median (IQR) EFV concentrations were 6.85 ng/mg (4.56-10.93) for hair and 1495.6 ng/ml (1050.7-2365.8) for DBS. Of the three measures of adherence, hair EFV concentration had the highest Area Under Curve (AUC) to predict viral suppression. Correlations between EFV concentrations in DBS and hair with PRA were positive (r = 0.12, P = 0.27 and r = 0.21, P = 0.05, respectively) but not strong.ConclusionsEFV concentrations in hair were the strongest predictor of viral suppression and only weakly correlated with pharmacy refill adherence data in Nigeria. This study suggests that resource-limited settings may benefit from objective adherence metrics to monitor and support adherence

Chromosome Study In Males Of Nearctic Species Of Gerris And Limnoporus Hemiptera Heteroptera Gerridae

Volume: 84Start Page: 535End Page: 53

Cytogenetic study in males of nearctic genera of Gerridae (Hemiptera: Heteroptera)

Volume: 86Start Page: 354End Page: 35