6,801 research outputs found
Towards a More Inclusive Music Education: Experiences of LGBTQQIAA Students in Music Teacher Education Programs Across Pennsylvania
During the past decade, the field of music education has seen an increase in the amount of scholarship surrounding LGBTQ studies in music teaching and learning. For example, the University of Illinois hosted three symposia for the field of music education dedicated to LGBTQ studies (2010, 2012, 2016), and proceedings from these symposia were published in three separate issues of the of the Bulletin of the Council for Research in Music Education (2011, 2014, 2016). Other notable scholarship has been published in Action, Criticism, and Theory for Music Education (Gould 2005); the Music Educators Journal (Bergonzi, 2009; Carter, 2011; McBride, 2016); the Journal of Research in Music Education (Carter, 2013; Nicholas, 2013); and UPDATE: Applications of Research in Music Education (Garrett, 2012). (excerpt
Generalized model of blockage in particulate flow limited by channel carrying capacity
We investigate stochastic models of particles entering a channel with a
random time distribution. When the number of particles present in the channel
exceeds a critical value , a blockage occurs and the particle flux is
definitively interrupted. By introducing an integral representation of the
particle survival probabilities, we obtain exact expressions for the survival
probability, the distribution of the number of particles that pass before
failure, the instantaneous flux of exiting particle and their time correlation.
We generalize previous results for to an arbitrary distribution of entry
times and obtain new, exact solutions for for a Poisson distribution and
partial results for .Comment: 13 pages, 9 figure
DNMTs are required for delayed genome instability caused by radiation
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited - Copyright @ 2012 Landes Bioscience.The ability of ionizing radiation to initiate genomic instability has been harnessed in the clinic where the localized delivery of controlled doses of radiation is used to induce cell death in tumor cells. Though very effective as a therapy, tumor relapse can occur in vivo and its appearance has been attributed to the radio-resistance of cells with stem cell-like features. The molecular mechanisms underlying these phenomena are unclear but there is evidence suggesting an inverse correlation between radiation-induced genomic instability and global hypomethylation. To further investigate the relationship between DNA hypomethylation, radiosensitivity and genomic stability in stem-like cells we have studied mouse embryonic stem cells containing differing levels of DNA methylation due to the presence or absence of DNA methyltransferases. Unexpectedly, we found that global levels of methylation do not determine radiosensitivity. In particular, radiation-induced delayed genomic instability was observed at the Hprt gene locus only in wild-type cells. Furthermore, absence of Dnmt1 resulted in a 10-fold increase in de novo Hprt mutation rate, which was unaltered by radiation. Our data indicate that functional DNMTs are required for radiation-induced genomic instability, and that individual DNMTs play distinct roles in genome stability. We propose that DNMTS may contribute to the acquirement of radio-resistance in stem-like cells.This study is funded by NOTE, BBSRC and the Royal Society Dorothy Hodgkin Research Fellowship
Reversible adsorption on a random site surface
We examine the reversible adsorption of hard spheres on a random site surface
in which the adsorption sites are uniformly and randomly distributed on a
plane. Each site can be occupied by one solute provided that the nearest
occupied site is at least one diameter away. We use a numerical method to
obtain the adsorption isotherm, i.e. the number of adsorbed particles as a
function of the bulk activity. The maximum coverage is obtained in the limit of
infinite activity and is known exactly in the limits of low and high site
density. An approximate theory for the adsorption isotherms, valid at low site
density, is developed by using a cluster expansion of the grand canonical
partition function. This requires as input the number of clusters of adsorption
site of a given size. The theory is accurate for the entire range of activity
as long as the site density is less than about 0.3 sites per particle area. We
also discuss a connection between this model and the vertex cover problem.Comment: 16 pages, 10 figure
Deviations from ozone photostationary state during the International Consortium for Atmospheric Research on Transport and Transformation 2004 campaign: Use of measurements and photochemical modeling to assess potential causes
Nitric oxide (NO) and nitrogen dioxide (NO2) were monitored at the University of New Hampshire Atmospheric Observing Station at Thompson Farm (TF) during the ICARTT campaign of summer 2004. Simultaneous measurement of ozone (O3), temperature, and the photolysis rate of NO2 (jNO2) allow for assessment of the O3 photostationary state (Leighton ratio, Φ). Leighton ratios that are significantly greater than unity indicate that peroxy radicals (PO2), halogen monoxides, nitrate radicals, or some unidentified species convert NO to NO2 in excess of the reaction between NO and O3. Deviations from photostationary state occurred regularly at TF (1.0 ≤ Φ ≤ 5.9), particularly during times of low NOx (NOx = NO + NO2). Such deviations were not controlled by dynamics, as indicated by regressions between Φ and several meteorological parameters. Correlation with jNO2 was moderate, indicating that sunlight probably controls nonlinear processes that affect Φ values. Formation of PO2 likely is dominated by oxidation of biogenic hydrocarbons, particularly isoprene, the emission of which is driven by photosynthetically active radiation. Halogen atoms are believed to form via photolysis of halogenated methane compounds. Nitrate radicals are believed to be insignificant. Higher Φ values are associated with lower mixing ratios of isoprene and chloroiodomethane and lower ratios of NOx to total active nitrogen, indicating that photochemical aging may very well lead to increased Φ values. PO2 levels calculated using a zero‐dimensional model constrained by measurements from TF can account for 71% of the observed deviations on average. The remainder is assumed to be associated with halogen atoms, most likely iodine, with necessary mixing ratios up to 0.6 or 1.2 pptv, for chlorine and iodine, respectively
An electron Talbot interferometer
The Talbot effect, in which a wave imprinted with transverse periodicity
reconstructs itself at regular intervals, is a diffraction phenomenon that
occurs in many physical systems. Here we present the first observation of the
Talbot effect for electron de Broglie waves behind a nanofabricated
transmission grating. This was thought to be difficult because of Coulomb
interactions between electrons and nanostructure gratings, yet we were able to
map out the entire near-field interference pattern, the "Talbot carpet", behind
a grating. We did this using a Talbot interferometer, in which Talbot
interference fringes from one grating are moire'-filtered by a 2nd grating.
This arrangement has served for optical, X-ray, and atom interferometry, but
never before for electrons. Talbot interferometers are particularly sensitive
to distortions of the incident wavefronts, and to illustrate this we used our
Talbot interferometer to measure the wavefront curvature of a weakly focused
electron beam. Here we report how this wavefront curvature demagnified the
Talbot revivals, and we discuss applications for electron Talbot
interferometers.Comment: 5 pages, 5 figures, updated version with abstrac
A preliminary evaluation of a new control-knob design for electronic equipment
Two experiments were carried out using five subjects to compare
performance using standard and flush fitting rotary controls for electronic
equipment. It vas found that the flush knob could be rotated more quickly
through several revolutions, but a given setting accuracy was achieved less
quickly using this flush knob.
Some of the more general advantages and disadvantages of the flush
knob are outlined.
It should be noted that the primary objective of this study was to
provide the participants with some experience in carrying out Human Factors
studies and the time allowed was not such as to permit a comprehensive
evaluation of the new knob design
Laminin and fibronectin in rectal adenocarcinoma: relationship to tumour grade, stage and metastasis.
Using an immunoperoxidase procedure, we have examined the distribution of laminin and fibronectin in normal human large intestinal mucosa and in 50 cases of rectal adenocarcinoma for which extensive clinical follow up was available. In normal tissue, laminin staining was largely restricted to basement membranes, including that underlying the epithelial cells, whereas fibronectin was found in both basement membranes and surrounding connective tissue. In rectal carcinomas, basement membrane-like staining for laminin associated with tumour cells was found in only 27 out of the 50 cases studied. Statistical analysis showed that the presence of laminin-containing basement membranes was correlated with low histological grade (well-differentiated tumours), but not with stage (progression through the bowel wall and the development of lymph node metastases) and, in a highly significant way, with a reduced incidence of distant metastases and increased patient survival. Although fibronectin was found in tumour cell basement membranes where these were present, it was also found in the stroma of all 50 tumours. There was no apparent correlation between the presence of stromal fibronectin and grade, stage or development of metastases. Finally, attention is drawn to some of the technical difficulties in detecting basement membrane antigens in formalin-fixed tissue, the material most frequently available for retrospective study
Oceanic influence on atmospheric mercury at coastal and inland sites: a springtime noreaster in New England
Continuous measurements of elemental (Hg<sup>0</sup>) and reactive mercury were conducted at two sites in New Hampshire during a powerful April 2007 noreaster. During the most intense period of the storm, enhancements of ~30–50 ppqv in Hg<sup>0</sup> were observed at a coastal and a high elevation inland site. This enhancement occurred simultaneously with elevated mixing ratios of three marine tracers, CH<sub>3</sub>I, CH<sub>2</sub>Br<sub>2</sub> and CHBr<sub>3</sub>. These observations suggest a marine source of Hg<sup>0</sup>, possibly outgassing from the ocean surface during strong turbulence. The Hg<sup>0</sup> enhancement observed 100 km inland suggests that the impact of coastal storms on terrestrial Hg cycling may not be limited to near-shore environments. Combining Hg<sup>0</sup> and marine tracer measurements during the storm with estimates of oceanic tracer fluxes during previous strong storms yields an order-of-magnitude estimate of the oceanic source of Hg<sup>0</sup> during the storm (~7 ppqv h<sup>&minus;1</sup>) which can account for the observed enhancement at the field sites
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