67 research outputs found
Utility of Superb Microvascular Imaging in the Assessment of Foot Perfusion in Patients with Critical Limb Ischemia
(1) Background: Although the ankle–brachial index (ABI) and skin perfusion pressure (SPP) are commonly used to evaluate the peripheral circulation in critical limb ischemia (CLI), they often cannot be performed on sore areas. We investigated the utility of superb microvascular imaging (SMI) for assessing foot perfusion in CLI patients.(2) Methods: We measured the SMI-based vascular index (SMI-VI) at six sites in the foot before and after endovascular treatment (EVT) in 50 patients with CLI who underwent EVT of the superficial femoral artery and compared the results with SPP values and the ABI.(3) Results: SMI visualized foot perfusion in all subjects in accordance with the angiosome, including the toe areas, while the ABI was unmeasurable in three patients on hemodialysis and SPP failed in four patients. SMI-VI values were significantly lower in the CLI group than in controls, and the plantar SMI-VI had the highest diagnostic performance for CLI (sensitivity 88.6%, specificity 95.6%). After EVT, the increase in the SMI-VI was positively correlated with the increase in SPP but not that in the ABI, implying that the SMI-VI reflects foot microcirculation. (4) Conclusions: SMI enables the visualization and quantification of foot microcirculation based on the angiosome. SMI has high utility as a tool for assessing foot perfusion in CLI
Effects of Esaxerenone on Diabetes-Induced Endothelial Dysfunction
Aims: Pharmacological blockade of mineralocorticoid receptors (MRs) is a potential therapeutic approach to reduce cardiovascular complications since MRs play a crucial role in cardiovascular regulation. Recent studies suggest that MR antagonists affect several extrarenal tissues, including vessel function. We investigated the effect of a novel nonsteroidal selective MR blocker, esaxerenone, on diabetes-induced vascular dysfunction.
Methods: Diabetes was induced by a single dose of streptozotocin in 8-week-old male C57BL/6 mice. Esaxerenone (3 mg/kg/day) or a vehicle was administered by gavage to diabetic mice for 3 weeks. Metabolic parameters, plasma aldosterone levels, and parameters related to renal function were measured. Endothelium-dependent or -independent vascular responses of the aortic segments were analyzed with acetylcholine or sodium nitroprusside, respectively. Human umbilical vein endothelial cells (HUVECs) were used for the in vitro study.
Results: Induction of diabetes elevated plasma aldosterone level (P<0.05) and impaired endothelium-dependent vascular relaxation (P<0.05). The administration of esaxerenone ameliorated the endothelial dysfunction (P<0.01) without the alteration of metabolic parameters, blood pressure, and renal function. Esaxerenone improved the eNOSSer1177 phosphorylation in the aorta obtained from diabetic mice (P<0.05) compared with that in the vehicle-treated group. Furthermore, a major MR agonist, aldosterone, decreased eNOSSer1177 phosphorylation and increased eNOSThr495 phosphorylation in HUVECs, which recovered with esaxerenone. Esaxerenone ameliorated the endothelium-dependent vascular relaxation caused by aldosterone in the aortic segments obtained from C57BL/6 mice (P<0.001).
Conclusion: Esaxerenone attenuates the development of diabetes-induced endothelial dysfunction in mice. These results suggest that esaxerenone has potential vascular protective effects in individuals with diabetes
Extreme Asymmetry in the Disk of V1247 Ori
We present the first near-infrared scattered-light detection of the
transitional disk around V1247 Ori, which was obtained using high-resolution
polarimetric differential imaging observations with Subaru/HiCIAO. Our imaging
in the H band reveals the disk morphology at separations of ~0.14"-0.86"
(54-330 au) from the central star. The polarized intensity (PI) image shows a
remarkable arc-like structure toward the southeast of the star, whereas the
fainter northwest region does not exhibit any notable features. The shape of
the arm is consistent with an arc of 0.28" 0.09" in radius (108 au from
the star), although the possibility of a spiral arm with a small pitch angle
cannot be excluded. V1247 Ori features an exceptionally large azimuthal
contrast in scattered, polarized light; the radial peak of the southeastern arc
is about three times brighter than the northwestern disk measured at the same
distance from the star. Combined with the previous indication of an
inhomogeneous density distribution in the gap at 46 au, the notable
asymmetry in the outer disk suggests the presence of unseen companions and/or
planet-forming processes ongoing in the arc.Comment: 21 pages, 5 figures, accepted for publication in PAS
The Structure of Pre-transitional Protoplanetary Disks I: Radiative Transfer Modeling of the Disk+Cavity in the PDS 70 system
Through detailed radiative transfer modeling, we present a disk+cavity model
to simultaneously explain both the SED and Subaru H-band polarized light
imaging for the pre-transitional protoplanetary disk PDS 70. Particularly, we
are able to match not only the radial dependence, but also the absolute scale,
of the surface brightness of the scattered light. Our disk model has a cavity
65 AU in radius, which is heavily depleted of sub-micron-sized dust grains, and
a small residual inner disk which produces a weak but still optically thick NIR
excess in the SED. To explain the contrast of the cavity edge in the Subaru
image, a factor of ~1000 depletion for the sub-micron-sized dust inside the
cavity is required. The total dust mass of the disk may be on the order of 1e-4
M_sun, only weakly constrained due to the lack of long wavelength observations
and the uncertainties in the dust model. The scale height of the
sub-micron-sized dust is ~6 AU at the cavity edge, and the cavity wall is
optically thick in the vertical direction at H-band. PDS 70 is not a member of
the class of (pre-)transitional disks identified by Dong et al. (2012), whose
members only show evidence of the cavity in the millimeter-sized dust but not
the sub-micron-sized dust in resolved images. The two classes of
(pre-)transitional disks may form through different mechanisms, or they may
just be at different evolution stages in the disk clearing process.Comment: 28 pages (single column), 7 figures, 1 table, ApJ accepte
Subaru near infrared coronagraphic images of T Tauri
High angular resolution near-infrared (JHK) adaptive optics images of T Tau were obtained with the infrared camera Coronagraphic Imager with Adaptive Optics (CIAO) mounted on the 8.2m Subaru Telescope in 2002 and 2004. The images resolve a complex circumstellar structure around a multiple system. We resolved T Tau Sa and Sb as well as T Tau N and S. The estimated orbit of T Tau Sb indicates that it is probably bound to T Tau Sa. The K band flux of T Tau S decreased by ˜ 1.7 Jy in 2002 November compared with that in 2001 mainly because T Tau Sa became fainter. The arc-like ridge detected in our near-infrared images is consistent with what is seen at visible wavelengths, supporting the interpretation in previous studies that the arc is part of the cavity wall seen relatively pole-on. Halo emission is detected out to ˜2\u27\u27from T Tau N. This may be light scattered off the common envelope surrounding the T Tauri multiple system
Subaru/HiCIAO imaging of LkH 330 - multi-band detection of the gap and spiral-like structures
We present - and -bands observations of the LkH 330
disk with a multi-band detection of the large gap and spiral-like structures.
The morphology of the outer disk (0\farcs3) at PA=0--45 and
PA=180--290 are likely density wave-induced spirals and comparison
between our observational results and simulations suggests a planet formation.
We have also investigated the azimuthal profiles at the ring and the outer-disk
regions as well as radial profiles in the directions of the spiral-like
structures and semi-major axis. Azimuthal analysis shows a large variety in
wavelength and implies that the disk has non-axisymmetric dust distributions.
The radial profiles in the major-axis direction (PA=) suggest that
the outer region (r\geq0\farcs25) may be influenced by shadows of the inner
region of the disk. The spiral-like directions (PA=10 and 230)
show different radial profiles, which suggests that the surfaces of the
spiral-like structures are highly flared and/or have different dust properties.
Finally, a color-map of the disk shows a lack of an outer eastern region in the
-band disk, which may hint the presence of an inner object that casts a
directional shadow onto the disk.Comment: 12pages, 16 figures, 2 tables, accepted for publication in A
A Young Brown Dwarf Companion to DH Tauri
We present the detection of a young brown dwarf companion DH Tau B associated
with the classical T Tauri star DH Tau. Near-infrared coronagraphic
observations with CIAO on the Subaru Telescope have revealed DH Tau B with H =
\~15 mag located at 2.3" (330 AU) away from the primary DH Tau A. Comparing its
position with a Hubble Space Telescope archive image, we confirmed that DH Tau
A and B share the common proper motion, suggesting that they are physically
associated with each other. The near-infrared color of DH Tau B is consistent
with those of young stellar objects. The near-infrared spectra of DH Tau B show
deep water absorption bands, a strong K I absorption line, and a moderate Na I
absorption line. We derived its effective temperature and surface gravity of
Teff = 2700 -- 2800 K and log g = 4.0--4.5, respectively, by comparing the
observed spectra with synthesized spectra of low-mass objects. The location of
DH Tau B on the HR diagram gives its mass of 30 -- 50 M_Jupiter.Comment: 10 pages, 14 figures, 1 table, accepted for publication in Ap
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