The Psychophysics of Harmony Perception: Harmony is a Three-Tone Phenomenon

In line with musical “common sense” (but contrary to the century-old tradition of musical psychophysics), we show that harmony is an inherently three-tone phenomenon. Previous attempts at explaining the affective response to major/minor chords and resolved/unresolved chords on the basis of the summation of interval dissonance have been notably unsuccessful, but consideration of the relative size of the intervals contained in triads leads directly to solutions to these historical problems. At the heart of our model is Leonard Meyer’s idea from 1956 concerning “intervallic equidistance” – i.e., the perception of “tension” inherent to any three-tone combination that has two intervals of equivalent size (e.g., the augmented chord). By including the effects of the upper partials, a psychophysical explanation of the perceived sonority of the triads (major>minor>diminished>augmented) and the affective valence of major and minor chords is easily achieved. We conclude that the perceptual regularities of traditional diatonic harmony are neither due to the summation of interval effects nor simply arbitrary, learned cultural artifacts, but rather that harmony has a psychophysical basis dependent on three-tone combinations

Why Not Study Polytonal Psychophysics?

The relative consonance/dissonance of 2-tone intervals is well understood both experimentally and theoretically and provides a strong foundation for explaining why diatonic scales or their subsets are used in most musical cultures. Frequent textbook assertions notwithstanding, however, the consonance of intervals fails to account for the basic facts of harmony (3 or more tone combinations). We have recently shown (Cook & Fujisawa, 2006) how consideration of 3-tone psychophysics can explain the fundamental regularities of diatonic harmony. Distinct from the dissonance of 2-tone intervals, 3-tone combinations introduce an effect described by Leonard Meyer (1956) as harmonic “tension”: when a third tone is located midway between an upper and a lower tone, the chord takes on an unresolved, unstable, tense character – a psychoacoustical property inherent to the diminished and augmented chords. If the effects of the upper partials are included in a formal model that includes both 2-tone and 3-tone effects, the perceived sonority of the triads (major>minor> diminished>augmented) is easily explained

Neural Basis of Psychological Growth following Adverse Experiences: A Resting-State Functional MRI Study

Over the past decade, research on the aftereffects of stressful or traumatic events has emphasized the negative outcomes from these experiences. However, the positive outcomes deriving from adversity are increasingly being examined, and such positive changes are described as posttraumatic growth (PTG). To investigate the relationship between basal whole-brain functional connectivity and PTG, we employed resting-state functional magnetic resonance imaging and analyzed the neural networks using independent component analysis in a sample of 33 healthy controls. Correlations were calculated between the network connectivity strength and the Posttraumatic Growth Inventory (PTGI) score. There were positive associations between the PTGI scores and brain activation in the rostral prefrontal cortex and superior parietal lobule (SPL) within the left central executive network (CEN) (respectively, r = 0.41, p < 0.001; r = 0.49, p < 0.001). Individuals with higher psychological growth following adverse experiences had stronger activation in prospective or working memory areas within the executive function network than did individuals with lower psychological growth (r = 0.40, p < 0.001). Moreover, we found that individuals with higher PTG demonstrated stronger connectivity between the SPL and supramarginal gyrus (SMG). The SMG is one of the brain regions associated with the ability to reason about the mental states of others, otherwise known as mentalizing. These findings suggest that individuals with higher psychological growth may have stronger functional connectivity between memory functions within the CEN and social functioning in the SMG, and that their better sociality may result from using more memory for mentalizing during their daily social interactions

Effect of the Nature of Subsequent Environment on Oxytocin and Cortisol Secretion in Maltreated Children

Childhood maltreatment (CM), including abuse and neglect is a crucial factor that distorts child development. CM is associated with alterations in numerous brain regions, and may be associated with neuropeptide hormonal dysregulation. This study aimed to investigate differences in secretion patterns of cortisol (CT) and oxytocin (OT) among children who experienced CM, children living in residential care facilities and in unstable environments. Among 38 maltreated children, 23 (mean age = 12.2 years, SD = 3.0) were categorized as Settled and 15 (mean age = 13.1 years, SD = 2.2) as Unsettled. Twenty-six age- and gender-matched (mean age = 12.6 years, SD = 2.1), typically developing (TD) children were also included. Clinical and psychological assessments, including IQ and trauma evaluations were conducted for all participants. Age, gender and full-scale IQ were used as covariates in hormone analysis. Two saliva samples were collected, one on awakening, the other at bedtime. There were significant differences in the awakening CT levels of the Unsettled group, and in bedtime OT levels in the Settled group as compared with TD children, and between CM groups. Furthermore, there was a significant difference in trauma-symptomatic depression scores between the Settled and Unsettled CM group. These results suggest that CT diurnal secretions tend to be reactive to current stress rather previous experience. OT diurnal secretions are presumably hyper-regulated for coping with the environment to survive and thrive. By measuring salivary CT/OT diurnal patterns, hormonal dysregulation of CM children living in Settled environments and Unsettled environments was indicated

How to Calculate "Harmoniousness" and Draw the Curves : Dissonance, Tension and Modality

和音(harmony) は，メロディ(melody). リズム(rhythm) とともに音楽を形作る重要な要素である.音楽の物理的な音響的特徴とその心理的な印象や感性との関連性について定量的に評価するために，和音性についての評価モデルを構築した.和音性は. (1)協和度(心地よいーわるい，澄んだー濁った).(2)緊張度(緊張したー落ちついた).さらに長調か短調かといった性質を決定する. (3)モダリティ(明るい一暗い，うれしいー悲しい)から構成される.本資料では. Cook & Fujisawa (2006) において議論されている和音性知覚モデルの詳細について補足的な説明を行う.具体的には，それぞれの和音性曲線(不協和度，緊張度，モダリティ)を得るための心理数理モデルの詳細と，実際に曲線を描くための計算プログラム(C言語・MATLAB)について解説する.In this paper，we provide further details on the harmony model discussed in Cook & Fujisawa (2006). The model curves for calculating the total "harmoniousness" (dissonance，tension and modality) of chords are described and the program (in the C language and MATLAB) needed for drawing the theoretical curves is presented

No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents

Background: Identification of gene × environment interactions (G × E) for depression is a crucial step in ascertaining the mechanisms underpinning the disorder. Earlier studies have indicated strong genetic influences and numerous environmental risk factors. In relation to childhood and adolescent depression, evidence is accumulating that the quality of the parental environment is associated with serotonin biology in children. We hypothesized that maternal depression is a crucial environmental risk factor associated with serotonin-regulating genes.Methods: This study was designed to ascertain the G × E interaction for diagnosis of depression in a Japanese pediatric sample. DNA samples from 55 pediatric patients with depression and 58 healthy schoolchildren were genotyped for the 5-HTT (2 short (S) alleles at the 5-HTT locus) promoter serotonin-transporter-linked polymorphic region (5-HTTLPR) polymorphism. We examined whether an adverse parental environment, operationalized as the mother\u27s history of recurrent major depressive disorder, interacts with 5-HTTLPR polymorphism to predict patients\u27 depression symptoms.Results: Binary logistic regression analyses revealed that maternal depression (adversity), gender, and FSIQ significantly affect the diagnosis of depression among children and adolescents. However, no main effect was found for adversity or genotype. Results of multivariable logistic regression analyses using stepwise procedure have elicited some models with a good fit index, which also suggests no interaction between 5-HTTLPR and adversity on depression.Conclusions: To assess G × E interaction, data obtained from children and adolescents who had been carefully diagnosed categorically and data from age-matched controls were analyzed using logistic regression. Despite an equivocal interaction effect, adversity and gender showed significant main effects

A comparative assessment of one\u27s own age from facial images of others: Two case studies for the Americans and the Japanese

We have proposed a method for estimating the subjective age of a person; that is, a method that yields a person\u27s age on the basis of estimations made by that person about the age of other people by observing their facial images. Thus far, experiments have shown that Japanese people tend to underestimate their subjective age. In this study, we focus on the socio-psychological effects that may influence the underestimation of subjective age. We conducted an international comparative study. In this study, experiments were performed in which American and Japanese participants viewed American facial images; in addition, the American participants also viewed Japanese facial images. Through these experiments, it was confirmed that the subjective age generally tended toward the negative direction despite differences in the nationalities and cultures of the Japanese and American participants and their facial images. Moreover, it was found that nationality and culture may have some effects on the estimation; for example, American males did not exhibit the tendency to underestimate the age, unlike Japanese male. When estimating facial images of different nationalities, the variance generally tended to be larger, although the average was similar. This study suggests that the underestimation of age occurs despite differences in Japanese and American societies and cultures; however, the tendency of underestimation of age is not related to facial images but to social and cultural factors that influence the participants

Type and Timing of Negative Life Events Are Associated with Adolescent Depression

Previous studies have demonstrated an association between negative life events (NLEs) in childhood and resilience/posttraumatic growth (PTG) with regard to the pathogenesis of major depressive disorder. We hypothesized that the type and timing of NLEs interact to influence mental health in the general youth population. Therefore, the present study aimed to examine the effects of NLE timing and intensity on current depressive symptoms, and to determine the direct and indirect effects of NLEs/resilience on PTG and depression among non-clinical adolescents. Data were collected from 1,038 high-school students across seven high schools in Fukui, Japan, during their freshman and sophomore years (648 boys and 390 girls, mean age = 15.71, SD = 0.524). Respondents completed a set of questionnaires designed to evaluate the type and timing of NLEs, depressive and traumatic symptoms, and PTG. Cluster analysis was used to divide participants into three groups based on outcomes: “cluster 1” (n = 631), for whom depressive scores were significantly lower than other two subgroups (p &lt; 0.05, for both); “cluster 2” (n = 52), for whom levels of current and past perceived stress associated with NLEs were significantly higher than those of the other two subgroups (p &lt; 0.05, for both); “cluster 3” (n = 374), for whom perceived stress at the time of NLE was significantly higher than that of participants in the cluster 1 (p &lt; 0.05) group, but not the cluster 2 group. Our findings indicated that exposure to NLEs at a younger age resulted in stronger negative outcomes and that NLE timing and intensity were associated with PTG and current symptoms of depression. Furthermore, path analysis demonstrated that associations between perceived stress at the time of NLEs were direct and indirect predictors of current depression via PTG and that posttraumatic stress symptom and PTG mediate the association between NLEs/trait-resiliency and current depression. In conclusion, our findings suggest that event intensity, NLE timing, and gender may play a role in emotional vulnerability during adolescence

Evaluation of the pooled sample method in Infinium MethylationEPIC BeadChip array by comparison with individual samples

Abstract Background The pooled sample method is used in epigenomic research and expression analysis and is a cost-effective screening approach for small amounts of DNA. Evaluation of the pooled sample method in epigenomic studies is performed using the Illumina Infinium Methylation 450K BeadChip array; however, subsequent reports on the updated 850K array are lacking. A previous study demonstrated that the methylation levels obtained from individual samples were accurately replicated using pooled samples but did not address epigenome-wide association study (EWAS) statistics. The DNA quantification method, which is important for the homogeneous mixing of DNA in the pooled sample method, has since become fluorescence-based, and additional factors need to be considered including the resolution of batch effects of microarray chips and the heterogeneity of the cellular proportions from which the DNA samples are derived. In this study, four pooled samples were created from 44 individual samples, and EWAS statistics for differentially methylated positions (DMPs) and regions (DMRs) were conducted for individual samples and compared with the statistics obtained from the pooled samples. Results The methylation levels could be reproduced fairly well in the pooled samples. This was the case for the entire dataset and when limited to the top 100 CpG sites, consistent with a previous study using the 450K BeadChip array. However, the statistical results of the EWAS for the DMP by individual samples were not replicated in pooled samples. Qualitative analyses highlighting methylation within an arbitrary candidate gene were replicable. Focusing on chr 20, the statistical results of EWAS for DMR from individual samples showed replicability in the pooled samples as long as they were limited to regions with a sufficient effect size. Conclusions The pooled sample method replicated the methylation values well and can be used for EWAS in DMR. This method is sample amount-effective and cost-effective and can be utilized for screening by carefully understanding the effective features and disadvantages of the pooled sample method and combining it with candidate gene analyses