64 research outputs found
2D Lattice Liquid Models
A family of novel models of liquid on a 2D lattice (2D lattice liquid models)
have been proposed as primitive models of soft-material membrane. As a first
step, we have formulated them as single-component, single-layered, classical
particle systems on a two-dimensional surface with no explicit viscosity. Among
the family of the models, we have shown and constructed two stochastic models,
a vicious walk model and a flow model, on an isotropic regular lattice and on
the rectangular honeycomb lattice of various sizes. In both cases, the dynamics
is governed by the nature of the frustration of the particle movements. By
simulations, we have found the approximate functional form of the frustration
probability, and peculiar anomalous diffusions in their time-averaged mean
square displacements in the flow model. The relations to other existing
statistical models and possible extensions of the models are also discussed.Comment: REVTeX4, 14 pages in double colomn, 12 figures; added references with
some comments, typos fixe
Cationic Porphyrin Induced a Telomeric DNA to G-Quadruplex Form in Water
The formation of the DNA G-quadruplex is induced by the addition of a novel porphyrin carrying four cationic tethers. Circular dichroism spectroscopy reveals that the porphyrin binds to Tetrahymena telomeric repeat to form G-quadruplex under stabilizing-cation-deficient and no buffer conditions
Reaction of 2-Nitroenamines and 2-Nitroalkenyl Sulfides with Ethyl Isocyanoacetate : a Novel Synthesis of 1-Hydroxypyrazoles
A new facet of the reaction of nitro heteroaromatic compounds with ethyl isocyanoacetate
Conformational, Dimensional, and Hydrodynamic Properties of Amylose Tris(n-butylcarbamate) in Tetrahydrofuran, Methanol, and Their Mixtures
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Macromolecules, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/ma902200z
Chain dimensions and hydration behavior of collagen model peptides in aqueous solution: [Glycyl-4(R)-hydroxyprolyl-4(R)-hydroxyproline]n, [Glycylprolyl-4(R)-hydroxyproline]n, and some related model peptides
Terao K., Mizuno K., Murashima M., et al. Chain dimensions and hydration behavior of collagen model peptides in aqueous solution: [Glycyl-4(R)-hydroxyprolyl-4(R)-hydroxyproline]n, [Glycylprolyl-4(R)-hydroxyproline]n, and some related model peptides. Macromolecules, 41(19), 7203-7210, September 4, 2008. Copyright © 2008, American Chemical Society. https://doi.org/10.1021/ma800790w
Phospholipase Cbeta4 and protein kinase Calpha and/or protein kinase CbetaI are involved in the induction of long term depression in cerebellar Purkinje cells.
Activation of the type-1 metabotropic glutamate receptor (mGluR1) signaling pathway in the cerebellum involves activation of phospholipase C (PLC) and protein kinase C (PKC) for the induction of cerebellar long term depression (LTD). The PLC and PKC isoforms that are involved in LTD remain unclear, however. One previous study found no change in LTD in PKCgamma-deficient mice, thus, in the present study, we examined cerebellar LTD in PLCbeta4-deficient mice. Immunohistochemical and Western blot analyses of cerebellum from wild-type mice revealed that PLCbeta1 was expressed weakly and uniformly, PLCbeta2 was not detected, PLCbeta3 was expressed predominantly in caudal cerebellum (lobes 7-10), and PLCbeta4 was expressed uniformly throughout. In PLCbeta4-deficient mice, expression of total PLCbeta, the mGluR1-mediated Ca(2+) response, and LTD induction were greatly reduced in rostral cerebellum (lobes 1-6). Furthermore, we used immunohistochemistry to localize PKCalpha, -betaI, -betaII, and -gamma in mouse cerebellar Purkinje cells during LTD induction. Both PKCalpha and PKCbetaI were found to be translocated to the plasmamembrane under these conditions. Taken together, these results suggest that mGluR1-mediated activation of PLCbeta4 in rostral cerebellar Purkinje cells induced LTD via PKCalpha and/or PKCbetaI
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